Biostability Assessment of Flexible Parylene C-based Implantable Sensor in Wireless Chronic Neural Recording

Lecomte, Aziliz; Degache, Amélie; Descamps, Emeline; Dahan, Lionel; Bergaud, Christian

doi:10.1016/j.proeng.2016.11.214

Cited by 10 publications

(4 citation statements)

References 6 publications

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“…When high impedances were observed, we ensured that there was no debris on top of the electrodes by forcefully pipetting the media to generate flow and observed the same impedance again. These impedance fluctuations, referred to as "blinking," have been reported before by others, in vitro [29] and when implanted in the brain. [30] Altogether, at any given timepoint six to seven of the ten electrodes were functional (Figure 2d).…”

mentioning

confidence: 99%

Stability of PEDOT:PSS‐Coated Gold Electrodes in Cell Culture Conditions

Dijk

Rutz

Malliaras

2019

Adv Materials Technologies

106

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Poly(3,4‐ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) is widely used as a coating on microelectrode arrays in order to reduce impedance for both in vitro and in vivo electrophysiology. In many applications, electrode performance of months to years is desired; yet, there are few studies to date that examine the long‐term stability of conducting polymers and their devices. Here, the stability of PEDOT:PSS microelectrodes is examined over a period of four months in cell culture media enriched with fetal bovine serum. The electrochemical impedance remains constant for most electrodes throughout the study, and only small changes in the structure of functional electrodes are observed. The results demonstrate that PEDOT:PSS electrodes show adequate stability for a variety of in vitro electrophysiology applications in toxicology, drug development, tissue engineering, and fundamental studies of electrically active cells and tissues.

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mentioning

confidence: 99%

Stability of PEDOT:PSS‐Coated Gold Electrodes in Cell Culture Conditions

Dijk

Rutz

Malliaras

2019

Adv Materials Technologies

106

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“…To support insertion, biodegradable silk fibrin was added to the stretchable parylene-C electrodes for easier surgery afterwards; the fibrin degraded over time. After six months of in vivo implantation in rat brains, 75% of these devices still showed a stable impedance for accurate recordings [ 44 ]. Currently, parylene-c is used as a substrate for neural electrodes due to its low modulus and chemical stability.…”

Section: Methodsmentioning

confidence: 99%

Flexible and Stretchable Bioelectronics

et al. 2022

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Medical science technology has improved tremendously over the decades with the invention of robotic surgery, gene editing, immune therapy, etc. However, scientists are now recognizing the significance of ‘biological circuits’ i.e., bodily innate electrical systems for the healthy functioning of the body or for any disease conditions. Therefore, the current trend in the medical field is to understand the role of these biological circuits and exploit their advantages for therapeutic purposes. Bioelectronics, devised with these aims, work by resetting, stimulating, or blocking the electrical pathways. Bioelectronics are also used to monitor the biological cues to assess the homeostasis of the body. In a way, they bridge the gap between drug-based interventions and medical devices. With this in mind, scientists are now working towards developing flexible and stretchable miniaturized bioelectronics that can easily conform to the tissue topology, are non-toxic, elicit no immune reaction, and address the issues that drugs are unable to solve. Since the bioelectronic devices that come in contact with the body or body organs need to establish an unobstructed interface with the respective site, it is crucial that those bioelectronics are not only flexible but also stretchable for constant monitoring of the biological signals. Understanding the challenges of fabricating soft stretchable devices, we review several flexible and stretchable materials used as substrate, stretchable electrical conduits and encapsulation, design modifications for stretchability, fabrication techniques, methods of signal transmission and monitoring, and the power sources for these stretchable bioelectronics. Ultimately, these bioelectronic devices can be used for wide range of applications from skin bioelectronics and biosensing devices, to neural implants for diagnostic or therapeutic purposes.

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“…Parylene has been also suggested as lipid membrane support with excellent stability [ 47 ]. Although parylene-based membrane patch fabrication and sensing have been currently implemented in biomedical applications for the development of wireless implantable sensors [ 48 ], their adoption to environmental sensing is expected to provide several advantages for reliable quality assessments.…”

Section: Methods For Preparing Biosensors Based On Lipid Filmsmentioning

confidence: 99%

Lipid Membrane Nanosensors for Environmental Monitoring: The Art, the Opportunities, and the Challenges

Nikoleli

Nikolelis

Siontorou

et al. 2018

Sensors

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The advent of nanotechnology has brought along new materials, techniques, and concepts, readily adaptable to lipid membrane-based biosensing. The transition from micro-sensors to nano-sensors is neither straightforward nor effortless, yet it leads to devices with superior analytical characteristics: ultra-low detectability, small sample volumes, better capabilities for integration, and more available bioelements and processes. Environmental monitoring remains a complicated field dealing with a large variety of pollutants, several decomposition products, or secondary chemicals produced ad hoc in the short- or medium term, many sub-systems affected variously, and many processes largely unknown. The new generation of lipid membranes, i.e., nanosensors, has the potential for developing monitors with site-specific analytical performance and operational stability, as well as analyte-tailored types of responses. This review presents the state-of-the art, the opportunities for niche applicability, and the challenges that lie ahead.

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Biostability Assessment of Flexible Parylene C-based Implantable Sensor in Wireless Chronic Neural Recording

Cited by 10 publications

References 6 publications

Stability of PEDOT:PSS‐Coated Gold Electrodes in Cell Culture Conditions

Stability of PEDOT:PSS‐Coated Gold Electrodes in Cell Culture Conditions

Flexible and Stretchable Bioelectronics

Lipid Membrane Nanosensors for Environmental Monitoring: The Art, the Opportunities, and the Challenges

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