Biostatistical analysis of the micronucleus mutagenicity assay based on the assumption of a mixing distribution.

Hothorn, Ludwig A.

doi:10.1289/ehp.94102s1121

Cited by 5 publications

(4 citation statements)

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“…Expression differences between groups were calculated using the Mann–Whitney U -test. Log Rank statistics (LR) was used for optimal cut point analysis ( Hothorn, 1994 ). Hardy–Weinberg analysis was performed using χ 2 or Fisher's exact test to examine differences in the distribution of alleles and genotypes.…”

Section: Methodsmentioning

confidence: 99%

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

et al. 2012

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Background:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.Methods:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease.Results:A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (−1306C>T) and MMP-9 (−1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification.Conclusion:MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients.

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Section: Methodsmentioning

confidence: 99%

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

et al. 2012

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“…In toxicology, tests based on this mixing distribution assumption were used for behavioral studies (44), teratological studies (45), sister chromatid exchange mutagenicity assays (42), chronic studies (5), and micronucleus mutagenicity assays (46). With simulation studies (42,46) The multivariate problem also consists of a complete hypothesis system of 2k -1 elementary hypotheses (21).…”

Section: Simultaneous Versus Sequential Rejective Proceduresmentioning

confidence: 99%

“…With simulation studies (42,46) The multivariate problem also consists of a complete hypothesis system of 2k -1 elementary hypotheses (21). The decision scheme is quite simple (51), as can be seen for the four end points in Figure 2.…”

Section: Simultaneous Versus Sequential Rejective Proceduresmentioning

confidence: 99%

Multiple comparisons in long-term toxicity studies.

Hothorn

1994

Environ Health Perspect

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Several multiple comparison procedures (MCPs) are discussed in relation to the specific formulation oftype I and type I errors in toxicity studies and the typical one-way design control versus k treatment/dose groups. Examples ofthese MCPs are: the standard many-to-one MCP (Dunnett's procedure), sequential rejection modifications, closedtesting procedures, many-to-one MCPs with an ordered alternative hypotheis, procedures based on the assumption ofa mixing distribution of responders and nonresponders, and MCP's for multiple end points.

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“…Normal function requires a specific number of cells with the proper characteristics in the correct location (Rodier, 1980). Cell migration enables that neurons reach their final location where they establish physical contact between themselves and construct complex circuits (Rodier, 1994). Connections occur via the process of synaptogenesis.…”

Section: Introductionmentioning

confidence: 99%

Neuropathological Sequelae of Developmental Exposure to Antiepileptic and Anesthetic Drugs

Turski¹,

Ikonomidou²

2012

Front. Neur.

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Glutamate (Glu) and γ-aminobutyric acid (GABA) are major neurotransmitters in the mammalian brain which regulate brain development at molecular, cellular, and systems level. Sedative, anesthetic, and antiepileptic drugs (AEDs) interact with glutamate and GABA receptors to produce their desired effects. The question is posed whether such interference with glutamatergic and GABAergic neurotransmission may exert undesired, and perhaps even detrimental effects on human brain development. Preclinical research in rodents and non-human primates has provided extensive evidence that sedative, anesthetic, and AEDs can trigger suicide of neurons and oligodendroglia, suppress neurogenesis, and inhibit normal synapse development and sculpting. Behavioral correlates in rodents and non-human primates consist of long-lasting cognitive impairment. Retrospective clinical studies in humans exposed to anesthetics or AEDs in utero, during infancy or early childhood have delivered conflicting but concerning results in terms of a correlation between drug exposure and impaired neurodevelopmental outcomes. Prospective studies are currently ongoing. This review provides a short overview of the current state of knowledge on this topic.

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Biostatistical analysis of the micronucleus mutagenicity assay based on the assumption of a mixing distribution.

Cited by 5 publications

References 20 publications

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

Multiple comparisons in long-term toxicity studies.

Neuropathological Sequelae of Developmental Exposure to Antiepileptic and Anesthetic Drugs

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