Biosurfactants

Martinotti, Maria Giovanna; Allegrone, Gianna; Cavallo, Marco; Fracchia, Letizia

doi:10.1002/9781118629703.ch9

Cited by 2 publications

(3 citation statements)

References 218 publications

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“…It is envisaged that more in-depth studies of the natural role of BSs in microbial competitive interactions, cell-to-cell communication, pathogenesis, motility and biofilm formation and maintenance will improve and suggest many other interesting potential applications [ 5 ].…”

Section: Biosurfactant Properties and Biological Activities Useful For Biomedical And Pharmaceutical Applicationsmentioning

confidence: 99%

“…Following on from functionality is the important consideration of production and downstream processing costs. Some problems must be solved to make the production of BS more profitable and economically feasible by (i) defining protocols to cultivate BS-producing bacterial strains or hyperproducing mutants on renewable cheap substrates; (ii) optimizing growth/production conditions; (iii) implementing large-scale production and recovery processes in order to compete economically with the chemical surfactants [ 5 ].…”

Section: Commercial Applications In the Biomedical And Pharmaceutical Fieldsmentioning

confidence: 99%

“…They have the ability to form molecular aggregates, including micelles. The micellar aggregation of BSs is originated at the critical micelle concentration (CMC) typically from 1 to 200 mg/L and, interestingly, about 10- to 40-fold lower than that of chemical surfactants [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated the urgent need for methods to combat such increasing threats. New avenues of research for natural molecules with desirable properties to alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group of unique and varied amphiphilic molecules of microbial origin capable of interacting with lipidic membranes/components of microorganisms and altering their physicochemical properties. These features have encouraged closer investigations of these microbial metabolites as new pharmaceutics with potential applications in clinical, hygiene and therapeutic fields. Mounting evidence has indicated that biosurfactants have antimicrobial, antibiofilm, antiviral, immunomodulatory and antiproliferative activities that are exploitable in new anticancer treatments and wound healing applications. Some biosurfactants have already been approved for use in clinical, food and environmental fields, while others are currently under investigation and development as antimicrobials or adjuvants to antibiotics for microbial suppression and biofilm eradication strategies. Moreover, due to the COVID-19 pandemic, biosurfactants are now being explored as an alternative to current products or procedures for effective cleaning and handwash formulations, antiviral plastic and fabric surface coating agents for shields and masks. In addition, biosurfactants have shown promise as drug delivery systems and in the medicinal relief of symptoms associated with SARS-CoV-2 acute respiratory distress syndrome.

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Section: Biosurfactant Properties and Biological Activities Useful For Biomedical And Pharmaceutical Applicationsmentioning

confidence: 99%

Section: Commercial Applications In the Biomedical And Pharmaceutical Fieldsmentioning

confidence: 99%

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Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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Biosurfactants as potential and sustainable substitutes for synthetic drugs against antimicrobial resistance and drug adverse effects: a review

Alara,

Alara

2024

ADV TRADIT MED (ADTM)

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Biosurfactants

Cited by 2 publications

References 218 publications

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

Biosurfactants as potential and sustainable substitutes for synthetic drugs against antimicrobial resistance and drug adverse effects: a review

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