Biosurfactants Against Drug‐Resistant Human and Plant Pathogens

Malakar, Chandana; Deka, Suresh

doi:10.1002/9781119671022.ch16

Cited by 8 publications

(8 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various literature has reported the wound healing efficacy of rhamnolipid. 8,24,25 However, there are no reports of wound healing efficacy of rhamnolipid in an infected wound. Hence, the approach to healing an infected wound is quite different than a normal wound.…”

Section: Discussionmentioning

confidence: 99%

“…With their reported antimicrobial activities, these secondary metabolites have been studied against various pathogens. 8 One of the intensely studied biosurfactants is rhamnolipid, which has been reported to exhibit efficient wound healing properties. Stipcevic et al (2006) reported that rhamnolipid can efficiently heal the wound developed due to burns.…”

Section: Introductionmentioning

confidence: 99%

“…Biosurfactant is one of the metabolites that has gained immense attention due to its multifarious activities. With their reported antimicrobial activities, these secondary metabolites have been studied against various pathogens 8 . One of the intensely studied biosurfactants is rhamnolipid, which has been reported to exhibit efficient wound healing properties.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wound healing efficacy of rhamnolipid‐coated zinc oxide nanoparticle along with its in vivo antibacterial efficacy against Staphylococcus aureus

Malakar

Kashyap

Kalita

et al. 2022

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

Rhamnolipids are microbial metabolites with antibacterial efficacies, which can be further boosted through the application of nanobiotechnology. In this study, the efficacy of rhamnolipid-coated zinc oxide nanoparticles (ZnRL) has been studied for their wound healing efficacy as well as in vivo antibacterial efficacy. Thus, this study evaluates the efficacy of ZnRL to heal an excised infected wound, which was compared with the healing efficacy of rhamnolipid and clindamycin. The study revealed that rhamnolipid-coated zinc oxide nanoparticles possess promising wound healing efficacy with prominent antibacterial activity in the rat model. Prominent wound healing in a Staphylococcus aureus infected excised wound was observed on the 5th day of the treatment when the wound site was treated with 100 μl of 0.5 mg/ml of ZnRL. This concentration of ZnRL was found to exhibit efficient antibacterial activity against the pathogen, thereby decreasing the amount of pathogen in the wound site. ZnRL exhibited efficient wound contraction, thereby decreasing the size of the wound prominently in 5 days. Histological study revealed efficient tissue remodelling in ZnRL-treated skin which resulted in rapid formation of the epidermis and recruitment of various dermal cells within the 5th day of treatment. The study also revealed the non-cytotoxic effect of the nanoparticles in fibroblast cell line L929 and the nonhaemolytic effect against blood cells, indicating its potential in pharmaceuticals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Wound healing efficacy of rhamnolipid‐coated zinc oxide nanoparticle along with its in vivo antibacterial efficacy against Staphylococcus aureus

Malakar

Kashyap

Kalita

et al. 2022

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nevertheless, microbial surfactants are classified according to the chemical structure and producing microorganisms (Malakar & Deka, 2021). They are categorized into molecules with a low molecular weight that efficiently declines surface and interfacial tension, and polymers of large molecular weight that well assist to stabilize emulsions (Rosenberg & Ron, 2013).…”

Section: Introductionmentioning

confidence: 99%

Isolation and Partial Characterization of Glycolipopeptide Biosurfactant Derived from A Novel Lactiplantibacillus plantarum Lbp_WAM

Al-Seraih

Swadi

Al-Hejjaj

et al. 2022

Basrah J. Agric. Sci.

View full text Add to dashboard Cite

Biosurfactants are amphipathic molecules generated by a variety of microorganisms with different biological functions. In this study, lactic acid bacteria were screened for their emulsification properties. However, the Lactiplantibacillus plantarum strain LBpWAM was molecularly identified using 16S rRNA, and its ability to produce surface-active peptides was investigated. The biosurfactant derived from L. plantarum LBp_WAM was shown to have the potential to reduce water surface tension from 72 mN.m-1 to 32 mN/m within a critical micelle concentration (CMC) of 2.4 mg.ml-1. The emulsification index (E24) values were evaluated for sunflower oil (60 ± 3.0%), glycerol (53.9 ± 0.11 %), olive oil (49.0 ± 2.0 %), mineral oil (50.7 ± 0.60 %), hexane (36.03±0.05 %), and kerosene (31 ±0.05 %). The biosurfactant was purified using gel filtration chromatography (GFC), and the molecular weight was determined using the SDS-PAGE method, indicating an approximate molecular weight of 19 kDa. Thin-layer chromatography (TLC) and Fourier transform infrared spectroscopy (FT-IR) were used to determine the molecular structure of the obtained molecule, which was found to be composed of protein, lipid, and polysaccharides. The biosurfactant's antibacterial activity was also examined, as it showed inhibitory effects against different species of Gram-positive and Gram-negative bacteria.

show abstract

“…The main strategy to control fungal infections at the postharvest level in fruit is the application of synthetic fungicides [9]. Nevertheless, these products have negative effects on human, animal, and environmental health [10,11] and induce resistance in phytopathogens [12,13].…”

Section: Introductionmentioning

confidence: 99%

A Sustainable Alternative for Postharvest Disease Management and Phytopathogens Biocontrol in Fruit: Antagonistic Yeasts

Hernández-Montiel

Droby

Rangel

et al. 2021

Plants

View full text Add to dashboard Cite

Postharvest diseases of fruits caused by phytopathogens cause losses up to 50% of global production. Phytopathogens control is performed with synthetic fungicides, but the application causes environmental contamination problems and human and animal health in addition to generating resistance. Yeasts are antagonist microorganisms that have been used in the last years as biocontrol agents and in sustainable postharvest disease management in fruits. Yeast application for biocontrol of phytopathogens has been an effective action worldwide. This review explores the sustainable use of yeasts in each continent, the main antagonistic mechanisms towards phytopathogens, their relationship with OMIC sciences, and patents at the world level that involve yeast-based-products for their biocontrol.

show abstract

Biosurfactants Against Drug‐Resistant Human and Plant Pathogens

Cited by 8 publications

References 123 publications

Wound healing efficacy of rhamnolipid‐coated zinc oxide nanoparticle along with its in vivo antibacterial efficacy against Staphylococcus aureus

Wound healing efficacy of rhamnolipid‐coated zinc oxide nanoparticle along with its in vivo antibacterial efficacy against Staphylococcus aureus

Isolation and Partial Characterization of Glycolipopeptide Biosurfactant Derived from A Novel Lactiplantibacillus plantarum Lbp_WAM

A Sustainable Alternative for Postharvest Disease Management and Phytopathogens Biocontrol in Fruit: Antagonistic Yeasts

Contact Info

Product

Resources

About