Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract

Abstract

This study reports the biological synthesis of gold nanoparticles (AuNPs) by the reduction of HAuCl 4 by using of Eclipta prostrata leaf extract as the reducing and stabilizing agent. AuNPs were characterized using Ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier Transform-Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), High Resolution-Transmission Electron Microscopy (HRTEM), and Energy Dispersive X-ray analysis (EDAX). The UV-visible spectrum of the synthesized AuNPs showed surface plasmon resonance (SPR) around 534 nm. The face-centered cubic (FCC) structure of the AuNPs was confirmed by XRD peaks at 38.10˝, 44.13˝, 64.43˝, and 77.32˝, which correspond to (111), (200), (220), and (311) miller indices, respectively, with clear circular spots in the selected area electron diffraction (SAED). FTIR measurements showed the AuNPs having a coating of phenolic compounds, indicating a possible role of biomolecules responsible for capping and efficient stabilization of the AuNPs. The HRTEM images determined the particles are spherical, hexagonal, and triangular in shape, with an average size of 31˘1.6 nm. The synthesized AuNPs show good antibacterial, antioxidant, and cytotoxic activity. The outcomes of this study indicate that these nanoparticles could be effectively utilized in pharmaceutical, biotechnological, and biomedical applications.

A comparative study on larvicidal potential of selected medicinal plants over green synthesized silver nano particles

“…Researchers has reported that synthesized AgNPs may have significant impact on malaria causing vectors and our results are in line with the previous results [17,18,26] similarly, Velayutham et al, [27] reported silver nanoparticles synthesized using bark aqueous extract of F. racemosa represented maximum larvicidal activity against the larvae of disease spreading vectors which is agrement with our study.…”

“…AgNPs were synthesized from the whole plant material (Phyllanthus amarus, Annona squamosa, Coccinia grandis and Eclipta prostrata) by the method explained by Rajakumar and Rahuman, [17]. Fig.…”

Nanomaterials-Based Electrochemical Sensors for In Vitro and In Vivo Analyses of Neurotransmitters

“…Numerous methods have been reported for the synthesis of noble metal-based nanoparticles, such as chemical reduction, hydrothermal, solvothermal, and thermal annealing methods, with controlled size and shape [13][14][15][16][17]. Among the noble metal-based nanomaterials, gold nanoparticles have been widely exploited for biomedical applications due to their peculiar properties such as chemical, optical, electrical, and catalytic biocompatibility and its ability to conjugate with biomolecules [18]. Silver nanoparticles have also been extensively explored for practical applications due to their highly selective and sensitive performance towards the detection of biomolecules [19][20][21].…”

A system for rapid and inexpensive treatment of sewage using the weed Eclipta prostrata in SHEFROL® bioreactor

“…; Rajakumar et al . ; Rajakumar & Rahuman ; Rajasekar et al . 2016) and assessment of their curative activity.…”

“…In addition it has been shown to have anti-HIV, antivenom, antidiabatic and antihelmintic attributes (Pithayanukul et al 2004;Tewtrakul et al 2007;Jahan et al 2014;Nathiya & Gayathri 2016;Kousalya et al 2017), and can protect against nurotoxicity (Jaisin et al 2016), infertility (Hung et al 2016), hepatotoxicity (Himaja and Neelufar Shama, 2015), and gastrointestinal disorders (Neamsuvan & Ruangrit 2017). These curative properties, especially against cancer and HIV, have led to extensive studies on nanoparticles synthesized biomimetically using aqueous extracts of E. prostrata (Chung et al , 2017Rajakumar et al 2012Rajakumar et al , 2015Rajakumar et al , 2016Rajakumar & Rahuman 2011;Rajasekar et al 2016) and assessment of their curative activity. Another manner in which E. prostrata has also been utilized is as a biosorbant (Chandra & Yadav 2017).…”