Biosynthesis and characterization of silver nanoparticles capped by biomolecules by fumaria parviflora extract as green approach and evaluation of their cytotoxicity against human breast cancer MDA-MB-468 cell lines

Sattari, Roshana; Khayati, Gholam Reza; Hoshyar, Reyhane

doi:10.1016/j.matchemphys.2019.122438

Cited by 19 publications

(7 citation statements)

References 25 publications

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“…Similarly, Jannathul Firdhouse M. & Lalitha P. reported IC 50 values of 3.04 μg/mL for AgNPs biosynthesized with Alternanthera sessilis against the MCF-7 cancer cell line that are higher doses that the ones we obtained 59 . Other studies also showed the IC 50 of d Fumaria parviflora extract and AgNPs- d Fumaria parviflora against MDA-MB-468 cancer cells were observed at 100 µg/mL and 80 µg/mL respectively 60 . Therefore, it is assumed that the potentiated effect of the nanoparticles is due to the component of the C. procumbens extracts (Table 2 ) that is working as a reducing and stabilizing agent of the AgNPs.…”

Section: Discussionmentioning

confidence: 85%

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

González-Pedroza

Benítez

Navarro-Marchal

et al. 2023

Sci Rep

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Nanotechnology is one of the most important and relevant disciplines today due to the specific electrical, optical, magnetic, chemical, mechanical and biomedical properties of nanoparticles. In the present study we demonstrate the efficacy of Cuphea procumbens to biogenerate silver nanoparticles (AgNPs) with antibacterial and antitumor activity. These nanoparticles were synthesized using the aqueous extract of C. procumbens as reducing agent and silver nitrate as oxidizing agent. The Transmission Electron Microscopy demonstrated that the biogenic AgNPs were predominantly quasi-spherical with an average particle size of 23.45 nm. The surface plasmonic resonance was analyzed by ultraviolet visible spectroscopy (UV–Vis) observing a maximum absorption band at 441 nm and Infrared Spectroscopy (FT IR) was used in order to structurally identify the functional groups of some compounds involved in the formation of nanoparticles. The AgNPs demonstrated to have antibacterial activity against the pathogenic bacteria Escherichia coli and Staphylococcus aureus, identifying the maximum zone of inhibition at the concentration of 0.225 and 0.158 µg/mL respectively. Moreover, compared to the extract, AgNPs exhibited better antitumor activity and higher therapeutic index (TI) against several tumor cell lines such as human breast carcinoma MCF-7 (IC50 of 2.56 µg/mL, TI of 27.65 µg/mL), MDA-MB-468 (IC50 of 2.25 µg/mL, TI of 31.53 µg/mL), human colon carcinoma HCT-116 (IC50 of 1.38 µg/mL, TI of 51.07 µg/mL) and melanoma A-375 (IC50 of 6.51 µg/mL, TI of 10.89 µg/mL). This fact is of great since it will reduce the side effects derived from the treatment. In addition, AgNPs revealed to have a photocatalytic activity of the dyes congo red (10–3 M) in 5 min and malachite green (10–3 M) in 7 min. Additionally, the degradation percentages were obtained, which were 86.61% for congo red and 82.11% for malachite green. Overall, our results demonstrated for the first time that C. procumbens biogenerated nanoparticles are excellent candidates for several biomedical and environmental applications.

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Section: Discussionmentioning

confidence: 85%

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

González-Pedroza

Benítez

Navarro-Marchal

et al. 2023

Sci Rep

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“…The average particle size, as calculated by DLS, was found to be 46.22 nm, which is higher than that detected by TEM analysis, owing to the polydisperse nature of the synthesized nanoparticles, as indicated by the polydispersity index value of 0.611 (Figure 9A). The accumulation of extra hydrate layers on the nanoparticle surface resulted in the detection larger biogenic ZnO nanoparticles than those detected by TEM analysis [69].…”

Section: Zeta Potential Analysis Of the Biogenic Znonpsmentioning

confidence: 94%

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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The high incidence of fungal resistance to antifungal drugs represents a global concern, contributing to high levels of morbidity and mortality, especially among immunocompromised patients. Moreover, conventional antifungal medications have poor therapeutic outcomes, as well as possible toxicities resulting from long-term administration. Accordingly, the aim of the present study was to investigate the antifungal effectiveness of biogenic zinc oxide nanoparticles (ZnO NPs) against multidrug-resistant candidal strains. Biogenic ZnO NPs were characterized using physicochemical methods, such as UV-vis spectroscopy, transmission electron microscopy (TEM), energy-dispersive X ray (EDX) spectroscopy, FTIR (Fourier transform infrared) spectroscopy and X-ray powder diffraction (XRD) analysis. UV spectral analysis revealed the formation of two absorption peaks at 367 and 506 nm, which preliminarily indicated the successful synthesis of ZnO NPs, whereas TEM analysis showed that ZnO NPs exhibited an average particle size of 22.84 nm. The EDX spectrum confirmed the successful synthesis of ZnO nanoparticles free of impurities. The FTIR spectrum of the biosynthesized ZnO NPs showed different absorption peaks at 3427.99, 1707.86, 1621.50, 1424.16, 1325.22, 1224.67, 1178.22, 1067.69, 861.22, 752.97 and 574.11 cm−1, corresponding to various functional groups. The average zeta potential value of the ZnO NPs was −7.45 mV. XRD analysis revealed the presence of six diffraction peaks at 2θ = 31.94, 34.66, 36.42, 56.42, 69.54 and 76.94°. The biogenic ZnO NPs (100µg/disk) exhibited potent antifungal activity against C. albicans, C. glabrata and C. tropicalis strains, with suppressive zone diameters of 24.18 ± 0.32, 20.17 ± 0.56 and 26.35 ± 0.16 mm, respectively. The minimal inhibitory concentration (MIC) of ZnO NPs against C. tropicalis strain was found to be 10 μg/mL, whereas the minimal fungicidal concentration (MFC) was found to be 20 μg/mL. Moreover, ZnO NPs revealed a potential synergistic efficiency with fluconazole, nystatin and clotrimazole antifungal drugs against C. albicans strain, whereas terbinafine, nystatin and itraconazole antifungal drugs showed a potential synergism with ZnO NPs against C. glabrata as a multidrug-resistant strain. In conclusion, pomegranate peel extract mediated green synthesis of ZnO NPs with potential physicochemical features and antimicrobial activity. The biosynthesized ZnO NPs could be utilized for formulation of novel drug combinations to boost the antifungal efficiency of commonly used antifungal agents.

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“…It has been widely accepted that if these coating agents themselves show biological activities, a synergistic effect between metal nanoparticles and these capped molecules would be anticipated. To date, several plant including Coconut inflorescence sap, 13 Citrus reticulata peels, 15 grape seed, 16 Arbutus unedo , 17 Nelumbo nucifera , 18,19 Fumaria parviflora , 20 and Coffea arabica 10 have been employed for biosynthesizing AgNPs with different physicochemical and biological properties. Especially, since it is rich of bioactive ingredients, traditional Chinese herbal medicines (CHMs) like Sea buckthorn , 21 Cornus officinalis , 22 Iresine herbstii , 23 Sesbania grandiflora 24 and Alpinia katsumadai 25 have also attracted enormous attentions for biosynthesizing medicinal AgNPs.…”

Section: Introductionmentioning

confidence: 99%

A novel green synthesis of silver nanoparticles by the residues of Chinese herbal medicine and their biological activities

et al. 2021

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Biosynthesis and characterization of silver nanoparticles capped by biomolecules by fumaria parviflora extract as green approach and evaluation of their cytotoxicity against human breast cancer MDA-MB-468 cell lines

Cited by 19 publications

References 25 publications

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

A novel green synthesis of silver nanoparticles by the residues of Chinese herbal medicine and their biological activities

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