Antioxidants - Benefits, Sources, Mechanisms of Action 2021
DOI: 10.5772/intechopen.96783
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Biosynthesis and Regulation of Antioxidant Flavonolignans in Milk Thistle

Abstract: Mature fruits (achenes) of milk thistle (Silybum marianum (L.) Gaertner, Asteraceae) accumulate high amounts of silymarin, a complex mixture of bioactive antioxidant flavonolignans deriving from taxifolin. Their biological activities in relation with human health promotion and disease prevention have been well described. The conditions of their biosynthesis in planta, however, have long been elusive and thus tend to be a limiting factor for their future applications. Significant advances in understanding their… Show more

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Cited by 2 publications
(2 citation statements)
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References 112 publications
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“…Flavonols are powerful antioxidants that may scavenge free radicals and protect liver cells from oxidative damage [ 81 ]. Oxidative stress is a key source of liver damage and inflammation, and flavonols like quercetin and kaempferol have been shown in animal experiments to protect against oxidative stress-induced liver damage [ 36 , 109 , 152 ]. Chronic inflammation can contribute to the development of liver disease, and flavonols have been discovered to have anti-inflammatory characteristics that can aid in the relief of liver inflammation [ 6 ].…”
Section: Main Textmentioning
confidence: 99%
“…Flavonols are powerful antioxidants that may scavenge free radicals and protect liver cells from oxidative damage [ 81 ]. Oxidative stress is a key source of liver damage and inflammation, and flavonols like quercetin and kaempferol have been shown in animal experiments to protect against oxidative stress-induced liver damage [ 36 , 109 , 152 ]. Chronic inflammation can contribute to the development of liver disease, and flavonols have been discovered to have anti-inflammatory characteristics that can aid in the relief of liver inflammation [ 6 ].…”
Section: Main Textmentioning
confidence: 99%
“…Finally, when it comes to the biosynthetic derivatives of silybin, most were found to be effective radical scavengers and lipid peroxidation inhibitors [ 127 ]. Although not in a NAFLD model, one particular interest was in 3-O-palmitoyl-silybin, a de novo synthetized compound that had stronger antioxidant and anti-lipoperoxidant protective effects than sylibin [ 128 ].…”
Section: Silymarin ( Silybum Marianum )mentioning
confidence: 99%