Biosynthesis of alkanes/alkenes from fatty acids or derivatives (triacylglycerols or fatty aldehydes)

Monteiro, Rodolpho R. C.; Silva, Silvia S.O. da; Cavalcante, Candice Torres de Melo Bezerra; Luna, F. Murilo T. de; Bolívar, Juan M.; Vieira, Rodrigo Silveira; Fernández‐Lafuente, Roberto

doi:10.1016/j.biotechadv.2022.108045

Cited by 16 publications

(5 citation statements)

References 283 publications

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“…Interestingly, various alkanes were produced by the three bacterial isolates using glucose, sucrose, and sugar cane molasses as carbon sources. This is consistent with previous studies that reported significant differences in hydrocarbon profiles produced by microorganisms based on carbon sources [28] As stated above, the chain length of alkanes produced by the present isolates ranged from C 8 to C 31 (Tables 1, 2,3,4,5,6,7,8,9). Previous studies have reported that bacterial alkanes typically have chain lengths ranging from C 10 to C 36 , although this can vary depending on the bacterial strain and environmental conditions [29].…”

Section: Effect Of Carbon Sources On Alkane Productionsupporting

confidence: 92%

“…This stability is critical for meeting the requirements of individual consumers as well as commercial and industrial sectors [ 4 ]. The traditional commercial production of alkanes constantly increases production costs, non-renewable energy consumption, and gaseous pollutants [ 5 ]. The microbial biosynthesis of alkanes can be a promising sustainable alternative for chemical production [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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The potential of Bacillus species isolated from Cinnamomum camphora for biofuel production

Hagaggi,

Rady

2024

Microb Cell Fact

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Background Increasing concerns about climate change and global petroleum supply draw attention to the urgent need for the development of alternative methods to produce fuels. Consequently, the scientific community must devise novel ways to obtain fuels that are both sustainable and eco-friendly. Bacterial alkanes have numerous potential applications in the industry sector. One significant application is biofuel production, where bacterial alkanes can serve as a sustainable eco-friendly alternative to fossil fuels. This study represents the first report on the production of alkanes by endophytic bacteria. Results In this study, three Bacillus species, namely Bacillus atrophaeus Camph.1 (OR343176.1), Bacillus spizizenii Camph.2 (OR343177.1), and Bacillus aerophilus Camph.3 (OR343178.1), were isolated from the leaves of C. camphora. The isolates were then screened to determine their ability to produce alkanes in different culture media including nutrient broth (NB), Luria–Bertani (LB) broth, and tryptic soy broth (TSB). Depending on the bacterial isolate and the culture media used, different profiles of alkanes ranging from C8 to C31 were detected. Conclusions The endophytic B. atrophaeus Camph.1 (OR343176.1), B. spizizenii Camph.2 (OR343177.1), and B. aerophilus Camph.3 (OR343178.1), associated with C. camphora leaves, represent new eco-friendly approaches for biofuel production, aiming towards a sustainable future. Further research is needed to optimize the fermentation process and scale up alkane production by these bacterial isolates.

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Section: Effect Of Carbon Sources On Alkane Productionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The potential of Bacillus species isolated from Cinnamomum camphora for biofuel production

Hagaggi,

Rady

2024

Microb Cell Fact

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“…Alkanes are hydrocarbons synthesized from fatty acids via decarbonylation ( Monteiro et al, 2022 ). Their relative content increased from 0.20 % to 1.20 %.…”

Section: Resultsmentioning

confidence: 99%

Succession of microbiota and its influence on the dynamics of volatile compounds in the semi-artificial inoculation fermentation of mulberry wine

Qin,

Xu,

Sun

et al. 2024

Food Chemistry: X

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“…Nevertheless, several short chain alkens were detected: butene and methylpentene were increased whilst propadiene, pentadiene and methylbutene were decreased. Decarboxylation of lipids may generate such byproducts [38] which also points toward a shift in energy metabolism.…”

Section: Discussionmentioning

confidence: 99%

Real-time breath metabolomics to assess early response to CFTR modulators in adults with cystic fibrosis: an open-label proof-of-concept study

Bardin,

Salvator,

Roquencourt

et al. 2024

Preprint

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BackgroundThe combination of CFTR modulators ivacaftor/tezacaftor/elexacaftor (ETI) achieves unprecedented improvements in clinical symptoms and respiratory function of people with cystic fibrosis. Yet, evaluation is difficult in people with high baseline lung function and the sweat test may vary depending on the type of CFTR mutation. Exhaled breath is a non-invasive sample, rich in personalised metabolic information and breathomics has emerged as a promising tool to monitor and assess therapeutic response. We hypothesised that ETI induces alterations in the breath composition and that these changes may correlate with clinical readouts.MethodsTen adults initiating ETI were enrolled in a prospective open-label study. Exhaled breath was analysed before, after one week and one month of treatment by real-time, proton transfer reaction-mass spectrometry. Clinical symptoms, lung function and sweat test results were recorded.ResultsA total of 29 breath samples were analysed; 108 volatile organic compounds (VOCs) were consistently detected. In responders (8/10), 21 VOCs were significantly modified, mostly hydrocarbons or small carbonyl compounds. At baseline, these VOCs exhibited significantly different concentrations compared to healthy young adults; throughout the first month of treatment, their level in CF breath evolved towards that of healthy volunteers. Eight of these also correlated with variations in lung function.ConclusionReal-time breath analysis identified alterations in the breath at the early stages of treatment that tended to normalise after one month. These changes exhibited correlations with clinical indicators, suggesting that breath VOCs may serve as early biomarkers useful for treatment monitoring.Trial registrationNCT05295524Key messagesWhat is already known on this topicAs efficient new generations of treatments are emerging for patients with CF, we are lacking early, non-invasive, personalised biomarkers associated with response to therapies. The previous generation of CFTR modulators modified the composition of breath within 3 months, yet nothing was known about the early impact of the newer combinations.What this study addsThe triple combination of CFTR modulators modifies the composition of breath in people with CF as soon as within one week of treatment and tends to normalise basal alterations in CF breath. These changes in breath composition may be captured with real-time mass spectrometry and correlate with clinical outcomes.How this study might affect research, practice or policyReal-time breath analysis may become useful in monitoring companion biomarkers associated with therapeutic response in patients with CF. Identification of related biological pathways could also help to elucidate the mode of action of these drugs.

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Biosynthesis of alkanes/alkenes from fatty acids or derivatives (triacylglycerols or fatty aldehydes)

Cited by 16 publications

References 283 publications

The potential of Bacillus species isolated from Cinnamomum camphora for biofuel production

The potential of Bacillus species isolated from Cinnamomum camphora for biofuel production

Succession of microbiota and its influence on the dynamics of volatile compounds in the semi-artificial inoculation fermentation of mulberry wine

Real-time breath metabolomics to assess early response to CFTR modulators in adults with cystic fibrosis: an open-label proof-of-concept study

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