Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties

Karanian, John W.; Kim, Hee Yong; SalemJr., Norman

doi:10.1007/978-1-4615-1959-1_33

Cardiovascular Disease 2 1995

DOI: 10.1007/978-1-4615-1959-1_33

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Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties

John W. Karanian¹,

Hee Yong Kim²,

Norman SalemJr.³

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1996

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The structure‐activity relationship of lipoxygenase products of long‐chain polyunsaturated fatty acids: Effects on human platelet aggregation

Karanian

Kim

Salem

1996

Lipids

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The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was determined to delineate potencies and structure-activity function. In this regard, the 22-carbon n-3 fatty acids are the most potent inhibitors in comparison to the n-6 lipoxygenase derivatives. Submicromolar levels of the docosapentaenoic (22:5) and especially docosahexaenoic (22:6) n-3 hydroperoxy and hydroxy derivatives specifically antagonize the platelet aggregating effect to arachidonic acid (AA, 20:4n-6) but not that of ADP or collagen. Chain length (22-C > 20-C), double-bond position (n-3 > n-6), and double-bond number (6 > 5 > 4) influence the degree of inhibition of AA-induced aggregation of human platelets. Moreover, significant differences in potency were associated with specific structural aspects of 22:6n-3 lipoxygenase derivatives of 22:6n-3 as follows: functional group (OOH > OH) and positional isomer (14-OOH, 14-OH, 20-OOH > 11-OOH, 17-OOH > 10-OOH > 11-OH, 8-OOH, 7-OOH > 4-OOH).

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The structure‐activity relationship of lipoxygenase products of long‐chain polyunsaturated fatty acids: Effects on human platelet aggregation

Karanian

Kim

Salem

1996

Lipids

Self Cite

View full text Add to dashboard Cite

show abstract

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Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties

Cited by 1 publication

References 21 publications

The structure‐activity relationship of lipoxygenase products of long‐chain polyunsaturated fatty acids: Effects on human platelet aggregation

The structure‐activity relationship of lipoxygenase products of long‐chain polyunsaturated fatty acids: Effects on human platelet aggregation

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