Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestris

Corsino, Joaquim; Carvalho, Paulo Roberto F de; Kato, Massuo Jorge; Latorre, Leandro Ribeiro; Oliveira, Olga Maria Mascarenhas Faria; Araújo, Ângela R.; Bolzani, Vanderlan S.; França, Suzelei de Castro; Pereira, Ana Maria Soares; Furlan, Maysa

doi:10.1016/s0031-9422(00)00285-5

Cited by 72 publications

(65 citation statements)

References 17 publications

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“…19) are characteristic of the Celastraceae and the closely related Hippocrateaceae. Studies of plants in the Celastraceae found that the quinone methides were located in root bark (as is the case with Tripterygium) but not in leaves, and that the friedelanes had the opposite distribution (Corsino et al, 2000). The best studied quinone methide is celastrol (65), sometimes called "tripterine" or "tripterin" in the literature; the compound was isolated and named by separate groups in the late 1930s -early 1940s (Yang, 1941).…”

Section: Triterpenesmentioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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Section: Triterpenesmentioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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“…In general, terpenes with antioxidant properties are rare, but some examples are common in species of the family Celastraceae, such as rosmanol, celastrol, maytenin, and pristimerin (Corsino et al, 2000;Carvalho et al, 2005). Among these compounds, two quinonemethide triterpenes have already been isolated from S. crassifolia: pristimerin and maytenin (Lima et al, 1969;Santana et al, 1971;Carvalho et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Carneiro

Silva²,

Menezes³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as "bacupari", "cascudo", and "saputá", is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of S. crassifolia stem bark fractions (hexane, ethyl acetate, and hydroalcoholic extracts) were evaluated using the mouse bone marrow micronucleus test. Our results showed that none of the S. crassifolia fractions led to a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) (P > 0.05), suggesting the absence of genotoxicity. In the antigenotoxicity assessment, a significant decrease in the MNPCE frequency was observed in all fractions of this plant (P < 0.05), demonstrating its protective action against genotoxicity induced by mitomycin C (MMC), which was used as the positive control. Only the hexane fraction of S. crassifolia significantly decreased the poly-and normochromatic erythrocyte ratio (PCE/NCE) in all doses tested (P < 0.05), demonstrating its cytotoxic activity. In association with MMC, both ethyl acetate and hydroalcoholic fractions significantly increased the PCE/NCE ratio in almost all doses tested (P < 0.05), demonstrating the protective action of S. crassifolia against the cytotoxic effect of the positive control. In contrast, the hexane fraction presented a significant decrease in the PCE/NCE ratio in all treatments (P < 0.05), demonstrating an increase in this plant's cytotoxicity in mouse bone marrow cells.

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“…Uma área de PN ainda pouco representativa é a de estudos biossintéticos, hoje limitados a dois grupos, um da UNESPAraraquara e outro da USP que, na maioria das vezes, trabalham em colaboração 27 .…”

Section: Produtos Naturais Marinhosunclassified