Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare

Banthorpe, D. V.; Bucknall, Graham A.; Doonan, Hilary J.; Doonan, Shawn; Rowan, Michael G.

doi:10.1016/s0031-9422(00)89061-5

Cited by 57 publications

(7 citation statements)

References 53 publications

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“…ACAT2, HMGCS1, HMGCR, MVK, PMVK are all crucial enzymes involved in mevalonate pathway, which is an important process of terpenoid backbone biosynthesis and is considered to be the only pathway of producing the precursors isopentenyl-PP (IPP) and dimethylallyl-PP (DMAPP) [ 41 ]. Next, the transformation of DMAPP and IPP was catalyzed into farnesyl-PP (FPP), which finally produces terpenoids with the help of farnesyl diphosphate synthase (FDPS) [ 42 , 43 ]. These highly activated enzymes involved in lipid metabolism and terpenoids biosynthesis indicated the increased amount of energy and lipids in the present study.…”

Section: Discussionmentioning

confidence: 99%

Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis

Wen

et al. 2018

BMC Genomics

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BackgroundSalinity is an important abiotic stress that influences the physiological and metabolic activity, reproduction, growth and development of marine fish. It has been suggested that half-smooth tongue sole (Cynoglossus semilaevis), a euryhaline fish species, uses a large amount of energy to maintain osmotic pressure balance when exposed to fluctuations in salinity. To delineate the molecular response of C. semilaevis to different levels of salinity, we performed RNA-seq analysis of the liver to identify the genes and molecular and biological processes involved in responding to salinity changes.ResultsThe present study yielded 330.4 million clean reads, of which 83.9% were successfully mapped to the reference genome of C. semilaevis. One hundred twenty-eight differentially expressed genes (DEGs), including 43 up-regulated genes and 85 down-regulated genes, were identified. These DEGs were highly represented in metabolic pathways, steroid biosynthesis, terpenoid backbone biosynthesis, butanoate metabolism, glycerolipid metabolism and the 2-oxocarboxylic acid metabolism pathway. In addition, genes involved in metabolism, osmoregulation and ion transport, signal transduction, immune response and stress response, and cytoskeleton remodeling were affected during acclimation to low salinity. Genes acat2, fdps, hmgcr, hmgcs1, mvk, pmvk, ebp, lss, dhcr7, and dhcr24 were up-regulated and abat, ddc, acy1 were down-regulated in metabolic pathways. Genes aqp10 and slc6a6 were down-regulated in osmoregulation and ion transport. Genes abat, fdps, hmgcs1, mvk, pmvk and dhcr7 were first reported to be associated with salinity adaptation in teleosts.ConclusionsOur results revealed that metabolic pathways, especially lipid metabolism were important for salinity adaptation. The candidate genes identified from this study provide a basis for further studies to investigate the molecular mechanism of salinity adaptation and transcriptional plasticity in marine fish.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-4825-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis

Wen

et al. 2018

BMC Genomics

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“…Other possible explanations, but less likely according to the authors, could be that DMAPP is derived from another pathway, along with compartmentation. Similarly in Tanacetum vulgare, Pelargonium graveolens and Mentha pulegium 115,121 it was found that in monoterpenes the labels of fed IPP are not uniformly channelled into the two C 5 -parts of the molecule. The portion of the molecule derived from IPP is usually more heavily labelled than that derived from DMAPP.…”

Section: Metabolic Pools Of Ipp and Dmappmentioning

confidence: 99%

Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function

Ramos-Valdivia¹,

Heijden²,

Verpoorte³

1997

Nat. Prod. Rep.

143

124

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“…Several investigations showed that citral is formed in many plants directly from geranyl diphosphate action resulting in geraniol, following its conversion into geranial and neral (Banthorpe, Bucknall, Doonan, Doonan, & Rowan, 1976;Iijima, Gang, Fridman, Lewinsohn, & Pichersky, 2004;Singh-Sangwan, Sangwan, Luthra, & Thakur, 1993). On the other hand, Cole & Kapur (1957a) reported citral isomers as degradation product of lycopene.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Impact of different large scale pasteurisation technologies and refrigerated storage on the headspace fingerprint of tomato juice

Aganovic

Grauwet

Kebede

et al. 2014

Innovative Food Science & Emerging Technologies

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Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare

Cited by 57 publications

References 53 publications

Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis

Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis

Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function

Impact of different large scale pasteurisation technologies and refrigerated storage on the headspace fingerprint of tomato juice

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