Biosynthesis of indolealkylamines. Physiological release and transport of 5-hydroxytryptamine

Hagen, Paul; Cohen, Lisa R.

doi:10.1007/978-3-642-85467-5_5

Cited by 14 publications

(13 citation statements)

References 125 publications

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“…Some investigations also strongly suggest the presence of 5-HT in close association with the intramural intestinal plexa (Tafuri and Raick 1964, Gershon and Ross 1966, Hammarstrom ct al. Enzymes necessary for the formation and breakdown of 5-HT are, however, present in the intestinal wall (Hagen and Cohen 1966), presumably also in intestinal nervous structures (Gershon and Ross 1966, Gershon 1970, Gershon and Altman 1971 2. Other authors have not been able to demonstrate the presence of 5-HT in intestinal nerve plexa (Norberg 1964, Read andBurnstock 1969), but have applied less sensitive techniques.…”

Section: Discussionmentioning

confidence: 99%

A Pharmacological Study of Intestinal Vasodilator Mechanisms in the Cat

Biber

Fara

Lundgren

1974

Acta Physiologica Scandinavica

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BIBER, B., J. FARA and 0. LUNDGREN. A pharmacological study of intestinal vasodilator mechanisms in the cat. Acta physiol. scand. 1974. 90. 673-683. The intestinal vasodilator responses evoked by close i.a. administration of cholecystokinin ( C C K ) and secretin, mechanical stimulation of the mucosa and transmural electrical field stimulation were abolished by the 5-hydroxytryptamine (5-HT) antagonist dihydroergotamine, given in doses sufficient to block the vascular effects of i.a. injected 5-HT. Corresponding results were obtained by making the cat small intestine tachyphylactic to 5-HT. Nervous blockade (tetrodotoxin) , inhibiting the intestinal blood flow increase after mechanical mucosal or electrical field stimulation, left the vascular responses to exogenous CCK and secretin unaffected. An increased 5-HT content in venous blood from the intestine was demonstrated during vasodilatations caused by electrical field stimulation. A participation of intestinal 5-HT, possibly as a transmitter substance, in the vasodilator mechanism evoked by mechanical mucosal stimulation o r electrical transmural field stimulation is suggested.Mesenteric blood flow increases following instillation of fat or acid into the duodenum, due at least in part to the release and action of the duodenal hormones cholecystokinin (CCK) and secretin (Fara, Rubinstein and Sonnenschein 1972).Further, mechanical stimulation of the intestinal mucosa causes an intestinal vasodilator response suggested to be mediated through a local intestinal nervous reflex (Biber, Lundgren and Svanvik 1971). Also, nervous structures in the intestinal wall can be directly activated by transmural electrical field stimulation (Biber, Fara and Lundgren 1973 a ) , causing an intestinal vasodilatation. Thus it seems likely that different trigger mechanisms are involved in rhe local regulation of intestinal blood flow.The question of whether a common mediator mechanism might be involved in the above mentioned intestinal vascular responses has been raised by several recent studies involving 5-hydroxytryptamine (5-HT ) and tetrodotoxin. The normal intestinal wall contains abundant amounts of 5-HT (Vialli 1966), and local i.a. administration of 5-HT evokes an intestinal vasodilator response, which regarding its effects on the consecutive vascular sections, closely resembles that induced by 3-743003. Acta physiol. scand. Vol. 90: 4 673

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Section: Discussionmentioning

confidence: 99%

A Pharmacological Study of Intestinal Vasodilator Mechanisms in the Cat

Biber

Fara

Lundgren

1974

Acta Physiologica Scandinavica

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“…Aromatic L-amino acid decarboxylase is widely distributed in mammalian tissues (283,339,571). In most species the kidney has been the richest source of the enzyme and considerable activity has also been found in adrenal medulla (861, liver, intestine, brain, pancreas, spleen, sympathetic ganglia, heart, and testis.…”

Section: Decarboxylationmentioning

confidence: 99%

Biochemistry and Physiology of Serotonergic Transmission

Gershon

1977

Comprehensive Physiology

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THE CONCERN of biologists with serotonin is a relatively recent phenomenon. However, its historical roots are considerably older than knowledge of the substance itself. It had been known since the nineteenth century that a vasoconstrictor substance was liberated from clotted blood (112, 113). Early efforts in 1911 (531) to measure epinephrine in blood were Involvement in sleep P 1 ate 1 e t s Depression 487 Behavior 28, 40 CNS neurons 1,3,91,158,651, 713 Control of brain serotonin (and bio-407, 408, 434-436 543, 565 312, 357, 451, 594, 743 synthesis) Gastrointestinal tract Pregnancy Schizophrenia and CNS disease Psychoactive compounds Distribution in various species Receptors Determination Endocrines Ontogeny Invertebrates Thermoregulation Turnover Migraine Depletors Transport and storage Inflammation and hypersensitivity General

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“…In man, approximately 2 % of dietary tryptophan is converted to 5-HT by hydroxylation and subsequent carboxylation (Hagen and Cohen , 1966). In man, approximately 2 % of dietary tryptophan is converted to 5-HT by hydroxylation and subsequent carboxylation (Hagen and Cohen , 1966).…”

Section: Serotoninmentioning

confidence: 99%

Antiasthmatic Drugs I

Rebuck

1974

Drugs

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Biosynthesis of indolealkylamines. Physiological release and transport of 5-hydroxytryptamine

Cited by 14 publications

References 125 publications

A Pharmacological Study of Intestinal Vasodilator Mechanisms in the Cat

A Pharmacological Study of Intestinal Vasodilator Mechanisms in the Cat

Biochemistry and Physiology of Serotonergic Transmission

Antiasthmatic Drugs I

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