“…recently to explore the chemical space of RiPPs involving MNIOs (24,25,28,30,47). To date, members of this superfamily of enzymes are known to catalyse remarkable oxidation reactions, including oxazolone coupled to thioamide formation, excision of cysteine β-methylene, Cysinvolved macrocyclization, and C-C and C-N cleavages, as evidenced in the biosynthesis of methanobactins, TglA-type pearlins, RiPPs in Chryseobacterium, aminopyruvatides, and methanobactin-like peptides in Vibrio, respectively (24,25,27,28,30). This work thus further expands the reaction spectrum of MNIOs.…”