Biosynthesis of magnesium oxide (MgO) nanoflakes by using leaf extract of Bauhinia purpurea and evaluation of its antibacterial property against Staphylococcus aureus

Das, Bhaskar; Moumita, Sahoo; Ghosh, Soumen; Khan, Md. Imran; Indira, Dash; Jayabalan, R.; Tripathy, Suraj K.; Mishra, Amrita; Balasubramanian, P.

doi:10.1016/j.msec.2018.05.059

Cited by 87 publications

(45 citation statements)

References 38 publications

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“…MgO NPs are effective antimicrobial agents showing bactericidal activity against both Gram-positive and -negative bacteria, spores and viruses [7]. As an electrochemical biosensor [8,9], with the ability of membrane disruption and reactive oxygen species (ROS) generation, it also inhibits the essential enzymes of bacteria [9][10][11]. Especially, MgO-based nanobiomaterials mimic the architecture and triggering of soluble ions as in natural bone tissue matrices.…”

Section: Introductionmentioning

confidence: 99%

Reliability of antioxidant potential and in vivo compatibility with extremophilic actinobacterial-mediated magnesium oxide nanoparticle synthesis

Kandiah

Jeevanantham

Balagurunathan

2019

Artificial Cells, Nanomedicine, and Biotechnology

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Owing to the hazards of chemical and physical syntheses of magnesium oxide nanoparticles (MgO NPs), an eco-friendly, high-yield, and promising biological method is highly desirable for biomedical applications. Hence, in this study, an extremophilic actinobacterial population (SA8 and SA10) from Salem magnesite mining soil was used as precursors for MgO NP synthesis. The prepared nanoparticles were subjected to X-ray diffraction study and showed face-centred cubic structure with an average particle size of 18-24 nm. Among all, high yield was obtained in SA10 actinobacteria-mediated synthesis of MgO NPs (480 mg/100 mL). In addition, the prepared MgO NPs (10 mg/well) showed 15-17 mm zone of inhibition against bacterial pathogens, especially bigger zones around SA10. The 64.5% antioxidant activity and nonsignificant toxicity of actinobacteria-synthesized MgO NPs in MG-63 cell lines at 100 mg/mL and nonsignificant in vivo toxicity in zebrafish at 0.1 mg/mL were remarkable. In addition, this is the first study to focus on MgO NP synthesis using extremophilic actinobacteria collected from Salem magnesite mining soil for high yield (115 mg/100 mL), reliable with potential antioxidant, and in vitro and in vivo compatibility. These results provided useful information for advanced research and mass production of NP for biomedical applications. GRAPHICAL ABSTRACT ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Reliability of antioxidant potential and in vivo compatibility with extremophilic actinobacterial-mediated magnesium oxide nanoparticle synthesis

Kandiah

Jeevanantham

Balagurunathan

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Spectrum adsorption of MgO nanoparticles measured in the range of 200-800 nm. Figure 2 shows the UV spectrum with a sharp peak at around 290 nm, which confirms the formation of MgO nanoparticles [28]. Besides, the precursor ion Mg 2+ , MgCl 2 salt does not show a spectrum at the specified wavelength.…”

Section: Characterization 321 Uv-vis Spectroscopy Of Bem and Mgonps Synthesizedmentioning

confidence: 75%

“…Total phenolic was estimated using the Follin-Ciocalteu test [27], and the result was expressed as microgram per milligram (µg/mg) gallic acid equivalent (GAE). Total flavonoid content was determined by the colorimetric AlCl 3 method, using catechin as standard and expressed as microgram per milligram (µg/mg) equivalent of catechin (CE) [28].…”

Section: Phytochemicals Analysismentioning

confidence: 99%

Antioxidant and Antibacterial Activities of Magnesium Oxide Nanoparticles Prepared using Aqueous Extract of Moringa Oleifera Bark as Green Agents

Amrulloh

Fatiqin

Simanjuntak

et al. 2021

J. Multidiscip. Appl. Nat. Sci.

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In this research, Magnesium oxide nanoparticles (MgONPs) was prepared from MgCl2 solution using aqueous extract of M. oleifera bark as green agent. Preparation procedure involved mixing of MgCl2.6H2O solution and the aqueous extract of M. oleifera bark, followed by drop wise addition of NaOH solution. The formation of MgO nanoparticles in this synthesis was confirmed using UV-Vis absorption. The spherical crystal structure of MgO nanoparticle confirmed XRD analysis. The average particle size of the synthesized MgO nanoparticles measured between 60 - 100 nm using SEM and TEM images and PSA results. MgONPs synthesized showed good antioxidant activity and antibacterial activity against S. aureus, E. faecalis, E. coli, and S. dysenteriae bacteria.

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“…Recently, Das et al proved that the antibacterial effects of nanostructured MgO were ROS-dependent based on the peroxide (H 2 O 2 ) detection. 81 Some bacteria such as S. aureus that undergo aerobic respiration also generate superoxide dismutase (SOD) to neutralize the ROS. If more ROS were produced and not timely neutralized by the SOD, the excess ROS could cause damage to the bacteria.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates

et al. 2020

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Magnesium (Mg) and its alloys have attracted increasing attention in recent years as medical implants for repairing musculoskeletal injuries because of their promising mechanical and biological properties. However, rapid degradation of Mg and its alloys in physiological fluids limited their clinical translation because the accumulation of hydrogen (H 2 ) gas and fast release of OH – ions could adversely affect the healing process. Moreover, infection is a major concern for internally implanted devices because it could lead to biofilm formation, prevent host cell attachment on the implants, and interfere osseointegration, resulting in implant failure or other complications. Fabricating nanostructured magnesium oxide (MgO) on magnesium (Mg) substrates is promising in addressing both problems because it could slow down the degradation process and improve the antimicrobial activity. In this study, nanostructured MgO layers were created on Mg substrates using two different surface treatment techniques, i.e., anodization and electrophoretic deposition (EPD), and cultured with Staphylococcus aureus in vitro to determine their antimicrobial properties. At the end of the 24-h bacterial culture, the nanostructured MgO layers on Mg prepared by anodization or EPD both showed significant bactericidal effect against S. aureus . Thus, nanostructured MgO layers on Mg are promising for reducing implant-related infections and complications and should be further explored for clinical translation toward antimicrobial biodegradable implants.

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Biosynthesis of magnesium oxide (MgO) nanoflakes by using leaf extract of Bauhinia purpurea and evaluation of its antibacterial property against Staphylococcus aureus

Cited by 87 publications

References 38 publications

Reliability of antioxidant potential and in vivo compatibility with extremophilic actinobacterial-mediated magnesium oxide nanoparticle synthesis

Reliability of antioxidant potential and in vivo compatibility with extremophilic actinobacterial-mediated magnesium oxide nanoparticle synthesis

Antioxidant and Antibacterial Activities of Magnesium Oxide Nanoparticles Prepared using Aqueous Extract of Moringa Oleifera Bark as Green Agents

Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates

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