Biosynthesis of oxylipins in non-mammals

Andreou, Alexandra Z.; Brodhun, Florian; Feußner, Ivo

doi:10.1016/j.plipres.2009.02.002

Cited by 276 publications

(248 citation statements)

References 231 publications

Supporting

Mentioning

233

Contrasting

Unclassified

Order By: Relevance

“…These proteins in plants are also important in the response to wounding and herbivory, and they play a relevant role in plant-pathogen interactions and oxidative burst. In addition, they are involved in the synthesis of the oxylipin jasmonates and the formation of lipoperoxides during the hypersensitive response (25). Conversely, a COP9 signalosome (CSN) subunit, reported as a negative regulator of the biosynthesis of oxylipins (24), is repressed.…”

Section: Discussionmentioning

confidence: 99%

An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development

Hernández‐Oñate¹,

Esquivel-Naranjo²,

Mendoza‐Mendoza

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

101

139

View full text Add to dashboard Cite

A conserved injury-defense mechanism is present in plants and animals, in which the production of reactive oxygen species (ROS) and lipid metabolism are essential to the response. Here, we describe that in the filamentous fungus Trichoderma atroviride, injury results in the formation of asexual reproduction structures restricted to regenerating cells. High-throughput RNA-seq analyses of the response to injury in T. atroviride suggested an oxidative response and activation of calcium-signaling pathways, as well as the participation of lipid metabolism, in this phenomenon. Gene-replacement experiments demonstrated that injury triggers NADPH oxidase (Nox)-dependent ROS production and that Nox1 and NoxR are essential for asexual development in response to damage. We further provide evidence of H 2 O 2 and oxylipin production that, as in plants and animals, may act as signal molecules in response to injury in fungi, suggesting that the three kingdoms share a conserved defense-response mechanism.conidiation | stress | transcriptome

show abstract

Section: Discussionmentioning

confidence: 99%

An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development

Hernández‐Oñate¹,

Esquivel-Naranjo²,

Mendoza‐Mendoza

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

101

139

View full text Add to dashboard Cite

show abstract

“…The hydroperoxide can be further converted to an alcohol-moiety to achieve the overall hydroxylation. Other follow-up reactions include epoxidation, C-C bond formation, C-C bond cleavage, ketone, and ether formation [28]. Further dioxygenases that convert fatty acids are α-dioxygenases (EC 1.14.99.-) producing α-or β-hydroperoxides [29], and diol synthases (EC 1.13.11.44) that are iron-dependent multi-domain enzymes producing diols from unsaturated fatty acids [19].…”

Section: Introductionmentioning

confidence: 99%

Regioselective Biocatalytic Hydroxylation of Fatty Acids by Cytochrome P450s

2017

View full text Add to dashboard Cite

show abstract

“…Oxylipins are among the signaling molecules involved in regulating plant development and immunity (López et al, 2008;Andreou et al, 2009;Kachroo and Kachroo, 2009). The biosynthesis of plant oxylipins is initiated by the action of 9-and 13-lipoxygenases, a-dioxygenases (a-DOX), or monooxygenases, all of which predominantly catalyze the oxygenation of linolenic acid (18:3) and linoleic acid (18:2) into reactive hydroperoxides, followed by secondary modification catalyzed mainly by cytochrome P450 enzymes or peroxygenases (Blée, 2002;Hamberg et al, 2002Hamberg et al, , 2003Andreou et al, 2009;Zoeller et al, 2012).…”

mentioning

confidence: 99%

“…The biosynthesis of plant oxylipins is initiated by the action of 9-and 13-lipoxygenases, a-dioxygenases (a-DOX), or monooxygenases, all of which predominantly catalyze the oxygenation of linolenic acid (18:3) and linoleic acid (18:2) into reactive hydroperoxides, followed by secondary modification catalyzed mainly by cytochrome P450 enzymes or peroxygenases (Blée, 2002;Hamberg et al, 2002Hamberg et al, , 2003Andreou et al, 2009;Zoeller et al, 2012). Oxylipins can also be produced nonenzymatically from polyunsaturated fatty acids in the presence of singlet oxygen or by free radical-mediated oxygenation (Durand et al, 2009).…”

mentioning

confidence: 99%

9-Lipoxygenase-derived oxylipins activate brassinosteroid signaling to promote cell wall-based defense and limit pathogen infection

et al. 2015

View full text Add to dashboard Cite

The oxylipins, a large family of oxygenated lipid derivatives, regulate plant development and immunity. Two members of the 9-lipoxygenase (9-LOX) oxylipin pathway, 9-hydroxyoctadecatrienoic acid and 9-ketooctadecatrienoic acid, control root development and plant defense. Studies in Arabidopsis (Arabidopsis thaliana) using a series of 9-hydroxyoctadecatrienoic acidand 9-ketooctadecatrienoic acid-insensitive nonresponding to oxylipins (noxy) mutants showed the importance of the cell wall as a 9-LOX-induced defense component and the participation of NOXY proteins in signaling cell wall damage. Here, we examined 9-LOX signaling using the mutants lox1lox5, which lacks 9-LOX activity, and noxy2-2, which shows oxylipin insensitivity and mitochondrial dysfunction. Mutants in brassinosteroids (BRs), a class of plant hormones necessary for normal plant growth and the control of cell wall integrity, were also analyzed. Several lines of evidence indicated that 9-LOX-derived oxylipins induce BR synthesis and signaling to activate cell wall-based responses such as callose deposition and that constitutive activation of BR signaling in bri1-EMS-suppressor 1-D (bes1-D) plants enhances this response. We found that constitutive BR signaling in bes1-D and brassinolide-resistant 1-1D (bzr1-1D) mutants conferred resistance to Pseudomonas syringae. bes1-D and bzr1-1D showed increased resistance to Golovinomyces cichoracearum, an obligate biotrophic fungus that penetrates the cell wall for successful infection, whereas susceptibility was enhanced in lox1lox5 and noxy2-2. Our results indicate a sequential action of 9-LOX and BR signaling in activating cell wall-based defense, and this response prevents pathogen infection. These results show interaction between the 9-LOX and BR pathways and help to clarify their role in modulating plant defense.

show abstract

Biosynthesis of oxylipins in non-mammals

Cited by 276 publications

References 231 publications

An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development

An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development

Regioselective Biocatalytic Hydroxylation of Fatty Acids by Cytochrome P450s

9-Lipoxygenase-derived oxylipins activate brassinosteroid signaling to promote cell wall-based defense and limit pathogen infection

Contact Info

Product

Resources

About