Biosynthesis of phyto functionalized cerium oxide nanoparticles mediated from Scoparia dulsis L. for appraisal of anti-cancer potential against adenocarcinomic lung cancer cells and paracetamol sensing potentiality

Navada, Meghana K.; Karnikkar, Nagaraja G.; D’Souza, Josline Neetha; Kouser, Sabia; Aroor, Ganesha; Kudva, Jyothi; Jayappa, Manasa Dogganal

doi:10.1007/s11356-022-23500-z

Cited by 12 publications

(5 citation statements)

References 67 publications

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“…These NMs can penetrate into the cells owing to their high chemical reactivity and cause the lysis of the cell. The acquired results correspond rather well with the findings of Navada et al [ 35 ]. The decrease in the viability of the cancerous cells was also found to be dose- as well as time-dependent.…”

Section: Resultssupporting

confidence: 91%

Cerium Oxide Nanorods Synthesized by Dalbergia sissoo Extract for Antioxidant, Cytotoxicity, and Photocatalytic Applications

Alam

Naeem

Usman³

et al. 2022

Molecules

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In this study, cerium oxide nanorods (CeO2-NRs) were synthesized by using the phytochemicals present in the Dalbergia sissoo extract. The physiochemical characteristics of the as-prepared CeO2-NRs were investigated by using ultraviolet-visible spectroscopy (UV-VIS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction analysis (XRD). The SEM and UV-VIS analyses revealed that the acquired nanomaterials possessed a rod-like morphology while the XRD results further confirmed that the synthesized NRs exhibited a cubic crystal lattice system. The antioxidant capacity of the synthesized CeO2-NRs was investigated by using several in vitro biochemical assays. It was observed that the synthesized NRs exhibited better antioxidant potential in comparison to the industrial antioxidant of the butylated hydroxyanisole (BHA) in 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The biochemical assays, including lipid peroxidation (LPO), total antioxidant capacity (TAC), and catalase activity (CAT), were also performed in the human lymphocytes incubated with the CeO2-NRs to investigate the impact of the NRs on these oxidative biomarkers. Enhanced reductive capabilities were observed in all the assays, revealing that the NRs possess excellent antioxidant properties. Moreover, the cytotoxic potential of the CeO2-NRs was also investigated with the MTT assay. The CeO2-NRs were found to effectively kill off the cancerous cells (MCF-7 human breast cancer cell line), further indicating that the synthesized NRs exhibit anticancer potential as well. One of the major applications studied for the prepared CeO2-NRs was performing the statistical optimization of the photocatalytic degradation reaction of the methyl orange (MO) dye. The reaction was optimized by using the technique of response surface methodology (RSM). This advanced approach facilitates the development of the predictive model on the basis of central composite design (CCD) for this degradation reaction. The maximum degradation of 99.31% was achieved at the experimental optimized conditions, which corresponded rather well with the predicted percentage degradation values of 99.58%. These results indicate that the developed predictive model can effectively explain the performed experimental reaction. To conclude, the CeO2-NRs exhibited excellent results for multiple applications.

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Section: Resultssupporting

confidence: 91%

Cerium Oxide Nanorods Synthesized by Dalbergia sissoo Extract for Antioxidant, Cytotoxicity, and Photocatalytic Applications

Alam

Naeem

Usman³

et al. 2022

Molecules

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“…This type of hysteresis occured mostly for plat-like layered pore structures. In similar study, desorption isotherm and existence of H3 & H2 hysteresis for smaller sized CeSD5, CeSD15, CeSD25 particles synthesized through Phyto-functionalization were reported ( Navada et al, 2023 ). Pore size distribution of this CeO 2 showed a mesoporous surface with a cumulative pore volume of 0.515 (ml/g) and average pore size of 60–160 nm.…”

Section: Resultsmentioning

confidence: 73%

Impact of CeO2 modified cathode and PANI modified anode on tannery wastewater fed microbial fuel cell performance

Waseem Mumtaz,

Mukhtar,

Miran

et al. 2024

Saudi Journal of Biological Sciences

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“…In the green synthesis of nanoparticles, plant extracts are used as secondary metabolites in a safe, environmentally friendly manner. Due to the association between plant material and metal precursors, this procedure reduces metal precursors to unique nanoparticles with unique properties ( Navada et al, 2023 ). The nucleophilic character of phenols and flavonoids and their affinity for metal ions make them essential components and chelating agents for synthesizing Au-NPs, as mentioned by Raghunandan et al (2010) .…”

Section: Resultsmentioning

confidence: 99%

Padina boergesenii mediated synthesis of Se-ZnO bimetallic nanoparticles for effective anticancer activity

Thirupathi,

Pongen,

Kaveriyappan

et al. 2024

Front. Microbiol.

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IntroductionEvaluating the anticancer property of Padina boergesenii mediated bimetallic nanoparticles.MethodsThe present study focuses on synthesizing Se-ZnO bimetallic nanoparticles from an aqueous algal extract of brown algae Padina boergesenii.Synthesized Se-ZnO NPs were characterized by UV, FTIR, SEM-EDS and HRTEM for confirmation along with the anticancer activity by MTT assay.ResultsThe UV gave an absorbance peak at 342 and 370 nm, and the FTIR showed functional groups involved in synthesizing Se-ZnO NPs. The TEM micrographs indicated the crystalline nature and confirmed the size of the Se-ZnO NPs to be at an average size of 26.14 nm. Anticancer efficacy against the MCF-7 breast and HepG2 (hepatoblastoma) cell lines were also demonstrated, attaining an IC50 value of 67.9 µg and 74.9 µg/ml respectively, which caused 50% cell death.DiscussionThis work aims to highlight an effective method for delivering bioactive compounds extracted from brown algae and emphasize its future therapeutic prospects. The potential of Selenium-Zinc oxide nanoparticles is of great interest due to the biocompatibility and low toxicity aspects of selenium combined with the cost-effectiveness and sustainability of zinc metal. The presence of bioactive compounds contributed to the stability of the nanoparticles and acted as capping properties.

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Biosynthesis of phyto functionalized cerium oxide nanoparticles mediated from Scoparia dulsis L. for appraisal of anti-cancer potential against adenocarcinomic lung cancer cells and paracetamol sensing potentiality

Cited by 12 publications

References 67 publications

Cerium Oxide Nanorods Synthesized by Dalbergia sissoo Extract for Antioxidant, Cytotoxicity, and Photocatalytic Applications

Cerium Oxide Nanorods Synthesized by Dalbergia sissoo Extract for Antioxidant, Cytotoxicity, and Photocatalytic Applications

Impact of CeO2 modified cathode and PANI modified anode on tannery wastewater fed microbial fuel cell performance

Padina boergesenii mediated synthesis of Se-ZnO bimetallic nanoparticles for effective anticancer activity

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