Biosynthesis of selenium-containing polysaccharides with antioxidant activity in liquid culture of Hericium erinaceum

Synthesis of selenium-containing polysaccharides and evaluation of antioxidant activity in vitro

“…Compared to the results, SeASP showed stronger scavenging effect than native ASP. This demonstrated that Se affected the antioxidant activity, which was in accordance with Malinowska et al that seleniumpolysaccharides showed greater antioxidant activity [2].…”

“…Apart from selenoproteins, natural or synthetic seleniumpolysaccharides compounds are explored as a novel selenium source in dietary supplements. It is reported that Se plays an important role in increasing the antiproliferative and antioxidant activity of Se-containing polysaccharides [2,5,7,8]. However, studies aimed at investigating the effects of chemical synthetic selenium-polysaccharides on antioxidant activities are limited.…”

“…This element is a cofactor of a large number of selenium-dependent enzymes such as an antioxidant enzyme, which is involved in cellular protection from severe oxidation by free radicals [2]. Diet is the major source of Se for general population and its bioavailability comes mainly from Se organic forms (generally more than 80%) [3].…”

Improved simultaneous production of mycelial biomass and polysaccharides by submerged culture of Hericium erinaceum: optimization using a central composite rotatable design (CCRD)

“…The exopolysaccharide isolated from a submerged mycelial culture of H. erinaceum was also found to exhibit stimulatory activity towards neurons in an in vitro model, and also to lower low-density lipoprotein (LDL) cholesterol and total cholesterol levels [21,32]. Antioxidant activity of H. erinaceum EPS has also been reported [14]. Therefore, both the cultivation of H. erinaceum on liquid artificial media and the isolation of polysaccharides that possess numerous favorable activities and can potentially become new anticancer agents or cancer-preventive nutraceuticals are highly desirable tasks.…”

Immune Enhancement of Hericium erinaceum Mycelium Cultured in Submerged Medium Supplemented with Ginseng Extract

“…In previous researches about component sugar of H. erinaceum, the antioxidant polysaccharide from mycelium mainly comprised major sugar such as galactose, glucose and mannose (Malinowska et al 2009), and fruiting body consisted mainly of glucose, galactose and small amount of fucose (Wang et al 2004). These reports were consistent with our results in terms of major component sugar was glucose and galactose, and uronic acid is less, suggesting that component sugar of mycelium was affected by GE-addition for fermentation.…”