Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity

Murugan, Kasi; Balakrishnan, Senthilkumar; Duraisamy, Senbagam; Al-Sohaibani, Saleh

doi:10.2147/ijn.s61779

Cited by 62 publications

(33 citation statements)

References 22 publications

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“…Thus, the particles might aggregate and flocculate due to the absence of a repulsive force. It was also observed that there was the presence of some weak peaks at 28°, 54°, 57° and 86° which might have been from the organic compound in the leaf extract (Figure 4) [21,22]. A study showed that in the biosynthesis of AgNPs by the reduction of Ag ions, the terpenoids in the leaf extract play a crucial role [19].…”

Section: Characterization Of Synthesized Silver Nanoparticlesmentioning

confidence: 98%

Green Synthesis and Characterization of Silver Nanoparticles Using Spondias mombin Extract and Their Antimicrobial Activity against Biofilm-Producing Bacteria

et al. 2021

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Multidrug resistant bacteria create a challenging situation for society to treat infections. Multidrug resistance (MDR) is the reason for biofilm bacteria to cause chronic infection. Plant-based nanoparticles could be an alternative solution as potential drug candidates against these MDR bacteria, as many plants are well known for their antimicrobial activity against pathogenic microorganisms. Spondias mombin is a traditional plant which has already been used for medicinal purposes as every part of this plant has been proven to have its own medicinal values. In this research, the S. mombin extract was used to synthesise AgNPs. The synthesized AgNPs were characterized and further tested for their antibacterial, reactive oxygen species and cytotoxicity properties. The characterization results showed the synthesized AgNPs to be between 8 to 50 nm with -11.52 of zeta potential value. The existence of the silver element in the AgNPs was confirmed with the peaks obtained in the EDX spectrometry. Significant antibacterial activity was observed against selected biofilm-forming pathogenic bacteria. The cytotoxicity study with A. salina revealed the LC50 of synthesized AgNPs was at 0.81 mg/mL. Based on the ROS quantification, it was suggested that the ROS production, due to the interaction of AgNP with different bacterial cells, causes structural changes of the cell. This proves that the synthesized AgNPs could be an effective drug against multidrug resistant bacteria.

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Section: Characterization Of Synthesized Silver Nanoparticlesmentioning

confidence: 98%

Green Synthesis and Characterization of Silver Nanoparticles Using Spondias mombin Extract and Their Antimicrobial Activity against Biofilm-Producing Bacteria

et al. 2021

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“…These compounds act as reducing and stabilizing agents of the AgNPs. Interestingly, plants have the incredible ability to enclose nanoparticles, forming a membrane around them and stopping the nanoparticles from forming aggregates, and in doing so stabilize the solution [20].…”

Section: The Bark Of Woody Vascular Plants—a Source Of Phytoconstimentioning

confidence: 99%

A Review of Bark-Extract-Mediated Green Synthesis of Metallic Nanoparticles and Their Applications

et al. 2019

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Nanoparticles are intensely studied because of their importance in diverse fields of biotechnology, especially in medicine. This paper highlights that waste bark can be a cheap source of biocompounds, with high recovery and functionalization potential in nanoparticle synthesis. Due to their biocompatibility and activity as antioxidant, antimicrobial, and anticancer agents, the green synthesis of metallic nanoparticles is of great importance. This review aims to bring together the diversity of synthesized metallic nanoparticles mediated by bark extracts obtained from different woody vascular plants, the phytoconstituents responsible for the reduction of metal salts, and the activity of metallic nanoparticles as diverse agents in combating the microbial, oxidant, and cancer activity. The literature data highlight the fact that metallic nanoparticles obtained from natural compounds are proven reducing agents with multiple activities. Thus, the activity of natural components in environmental protection and human health is confirmed.

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“…Metal-based NPs have a broad antibacterial effect on a range of gram-negative and -positive bacteria and antibiotic-resistant bacteria strains (Ge et al, 2014). Although Ag NPs alone are strong bactericidal agents (Murugan et al, 2014), they are also cytotoxic (Ge et al, 2014). Embedding them in a polymer matrix may reduce their cytotoxicity (Liu et al, 2010).…”

Section: Unique Physical and Chemical Properties Of Nanomaterialsmentioning

confidence: 99%

Potential applications and human biosafety of nanomaterials used in nanomedicine

Bowman

et al. 2017

J of Applied Toxicology

138

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With the rapid development of nanotechnology, potential applications of nanomaterials in medicine have been widely researched in recent years. Nanomaterials themselves can be used as image agents or therapeutic drugs, and for drug and gene delivery, biological devices, nanoelectronic biosensors or molecular nanotechnology. As the composition, morphology, chemical properties, implant sites as well as potential applications become more and more complex, human biosafety of nanomaterials for clinical use has become a major concern. If nanoparticles accumulate in the human body or interact with the body molecules or chemical components, health risks may also occur. Accordingly, the unique chemical and physical properties, potential applications in medical fields, as well as human biosafety in clinical trials are reviewed in this study. Finally, this article tries to give some suggestions for future work in nanomedicine research.

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Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity

Cited by 62 publications

References 22 publications

Green Synthesis and Characterization of Silver Nanoparticles Using Spondias mombin Extract and Their Antimicrobial Activity against Biofilm-Producing Bacteria

Green Synthesis and Characterization of Silver Nanoparticles Using Spondias mombin Extract and Their Antimicrobial Activity against Biofilm-Producing Bacteria

A Review of Bark-Extract-Mediated Green Synthesis of Metallic Nanoparticles and Their Applications

Potential applications and human biosafety of nanomaterials used in nanomedicine

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