1999
DOI: 10.1074/jbc.274.45.32127
|View full text |Cite
|
Sign up to set email alerts
|

Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

18
380
0
9

Year Published

2000
2000
2017
2017

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 299 publications
(408 citation statements)
references
References 40 publications
18
380
0
9
Order By: Relevance
“…Subsequently, the propeptides can be proteolytically removed to generate mature forms consisting of VHD dimers. The full-length forms of both growth factors bind the lymphangiogenic receptor VEGFR-3 but the mature forms do so with greater affinity (Joukov et al, 1997;Stacker et al, 1999), suggesting that the degree of proteolytic processing of VEGF-C and VEGF-D may in part determine the extent of lymphangiogenesis induced by these proteins in a tumour. Once VEGF-C is processed to the mature form it acquires the capacity to bind VEGFR-2 (Joukov et al, 1997), a cell surface receptor tyrosine kinase thought to signal for angiogenesis.…”
Section: Mechanisms Of Lymphangiogenic Signallingmentioning
confidence: 99%
See 1 more Smart Citation
“…Subsequently, the propeptides can be proteolytically removed to generate mature forms consisting of VHD dimers. The full-length forms of both growth factors bind the lymphangiogenic receptor VEGFR-3 but the mature forms do so with greater affinity (Joukov et al, 1997;Stacker et al, 1999), suggesting that the degree of proteolytic processing of VEGF-C and VEGF-D may in part determine the extent of lymphangiogenesis induced by these proteins in a tumour. Once VEGF-C is processed to the mature form it acquires the capacity to bind VEGFR-2 (Joukov et al, 1997), a cell surface receptor tyrosine kinase thought to signal for angiogenesis.…”
Section: Mechanisms Of Lymphangiogenic Signallingmentioning
confidence: 99%
“…Once VEGF-C is processed to the mature form it acquires the capacity to bind VEGFR-2 (Joukov et al, 1997), a cell surface receptor tyrosine kinase thought to signal for angiogenesis. In the case of VEGF-D, the affinity for VEGFR-2 is increased approximately 290-fold by proteolytic conversion of the full-length to the mature form (Stacker et al, 1999). Hence the mature forms of VEGF-C and VEGF-D can induce angiogenesis (Cao et al, 1998;Rissanen et al, 2003).…”
Section: Mechanisms Of Lymphangiogenic Signallingmentioning
confidence: 99%
“…They are specific ligands for the tyrosine kinase receptor, vascular endothelial growth factor receptor (VEGFR)-3 (flt-4) (Joukov et al, 1996;Achen et al, 1998). Both cytokines are subject to proteolytic processing, which also enables them to act as ligands for VEGFR2 (KDR/flk-1) Stacker et al, 1999). Vascular endothelial growth factor receptor 2 is expressed on vascular endothelial cells and is essential for the embryonic differentiation of endothelial and haematopoietic cells and formation of blood vessels (reviewed in Veikkola et al, 2000).…”
mentioning
confidence: 99%
“…Of interest, blood vascular endothelial cells also express VEGF-C , suggesting possible paracrine mechanisms by which the blood vascular system may control lymphatic vessel growth and/or maintenance. Both VEGF-C and VEGF-D are produced as precursor proteins with N-and C-terminal propeptides flanking the VEGF homology domain Stacker et al, 1999). The secreted factors undergo proteolytic processing that results in increased affinity for VEGFR-2 and, consequently, in their ability to induce angiogenesis in vivo (Cao et al, 1998).…”
Section: Vegf-c and Vegf-dmentioning
confidence: 99%