Biosynthesized silver nanoparticles (using Cinnamomum zeylanicum bark extract) improve the fertility status of rats with polycystic ovarian syndrome

Alwan, Shukrya; AL-Saeed, Muna H.

doi:10.1016/j.bcab.2021.102217

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…Indeed, ovarian tissue changes in the PCOS group in the present study were consistent with others [30][31][32], indicating the successful induction of PCOS with EV and defects in the development of follicular clusters in adult rats compared to the non-PCOS control group. Also, it seems that angiogenesis is likely due to increased expression of vascular endothelial growth factor and isoenzyme 2 cyclooxygenase in the stroma; this was also confirmed by observing a follicular increase in the sheath layer and androgen production or progression of steroidogenesis with thickening of this layer [11,30].…”

Section: Discussionmentioning

confidence: 79%

“…Establishing the estrous cycle was followed using vaginal smears, which were obtained between 08:00 and 12:00. ey were then evaluated by light microscopy for the relative proportion of leukocytes, epithelial, and cornified cells found in daily vaginal smear (Figures 1(a)-1(f )), which characteristically changes during different stages of the estrous cycle. e rat estrous cycle (estrus, diestrus 1, metestrus, and proestrus) usually took about 4 days, in both control and OE-treatment groups [11].…”

Section: Preparation Of Vaginal Smearsmentioning

confidence: 99%

“…injection of 0.2 mlcorn oil and the PCOS rats received an i.m. injection of 0.2 mgestradiol valerate (EV) (Aburaihan Co., Iran) in 0.2 ml of corn oil, to induce PCOS, accordingly [11].…”

Section: Hormone Treatment Proceduresmentioning

confidence: 99%

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Long Term Oral Administration of Oregano Essence Effectively Relieves Polycystic Ovarian Rats through Endocrine and Inflammatory Balance

Ranjbary

Mehrzad

Garoussi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Polycystic ovarian syndrome (PCOS) is alarmingly rising and sustainable therapy/prevention is needed. Here, we evaluated the therapeutic e ects of oregano or Origanum vulgare (O. vulgare) essence (OE) on the PCOS rat model system. Vaginal smears monitored the estrous cycle of 40 virgin adult rats, and they received 2 mg estradiol valerate (EV)/0.2 ml corn oil intramuscularly to induce PCOS. At 60 days post-EV injection, all rats were evaluated for follicular development/cysts. e EV-induced PCOS rats were orally administered 250 and 500 mg/kgBW/day of OE for 30 days. OE was also further assessed for its predominant components along with hormonal, histological, and in ammatory-related gene expressions in the ovaries. e main components of the OE were predominantly pulegone (36.3), L-menthone (31.3%), far less piperitone (7.8%), isopiperitone (6.4%), isomenthol (3.6%), humulene epoxide II (2.2%), α-pinene (1.7%), and thymol (1.5%). Hormonal, histological, and in ammatory-related gene expression results showed >4-fold and 1.5-fold increase in FSH and progesterone; ∼50%, 85%, 45%, 55%, and 30% decreased in LH, estradiol, estrogen, testosterone, and AMH; and dose-dependently decreased in mRNA expression of IL-6, IL-1α, NF-kB, TNF-α, and IL-1β by 25-65%, 55-75%, 15-40%, 30-55%, and 35-55%, respectively, and thus decreased the severity of PCOS, boosted endocrine balance, restored functional follicles and corpus luteum, and thus ovulation in PCOS rats. Overall, in the disrupted PCOS rats, OE oral treatment e ectively relieved estradiol-induced PCOS rats via: (1) its endocrine balancing on GnRH, FSH, and LH and (2) its anti-in ammatory and antioxidant properties on ovary caused by OE's useful compounds like pulegone, thymol, and L-menthone. ough many aspects of the e ects remain to be tested, such an underlying mechanistic reproductive regulatory e ect observed in OE-administered rats further proves its sensible pharmaceutical applications in reproductive medicine and more speci cally, PCOS.

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Section: Discussionmentioning

confidence: 79%

Section: Preparation Of Vaginal Smearsmentioning

confidence: 99%

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Long Term Oral Administration of Oregano Essence Effectively Relieves Polycystic Ovarian Rats through Endocrine and Inflammatory Balance

Ranjbary

Mehrzad

Garoussi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The extracellular phyto-synthesis method has several advantages to obtain metal nanoparticles, firstly, the plants are easily accessible, safe to handle, and have a great variety of phytochemical compounds. In the second place, many plants are well known by their medicinal properties, that could enhance the therapeutic efficiency of the nanoparticle [18] .…”

Section: Introductionmentioning

confidence: 99%

“…The Cinnamomum verum is a medicinal plant with well known therapeutic properties, such as anti-oxidant, antidiabetic, antimicrobial and anti-inflammatory effects [18][19][20][21][22][23] . Several authors have used different parts of Cinnamomum verum plants to perform green synthesis of nanoparticles [18,[24][25][26][27] .…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol)/poly(glycerol) dendrimer hydrogel mediated green synthesis of silver nanoparticles

et al. 2022

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In this paper, we report the synthesis and evaluation of a poly(vinyl alcohol)/poly(glycerol) dendrimer hydrogel incorporated with green synthesized silver nanoparticles (PVA/PGLD-AgNPs) using Cinnamomum verum extract as the reducting agent (Cz-extract). The Cz-extract was prepared using ultrasonic technique. UV-visible (UV-vis) spectra of Cz-extract confirmed the presence of cinnamaldehyde. PVA/PGLD-AgNPs films were prepared using 5, 10 and 20 mL of Cz-extract and characterized by UV-vis, Fourier transform infrared spectroscopy, Thermogravimetric analysis and X-ray diffraction (XRD). The surface plasmon resonance band in the UV-vis spectra confirmed the formation of AgNPs. XRD pattern confirmed the presence of silver, with average crystallite sizes calculated by Scherrer equal to 13.64 nm, 16.63nm and 20.27 nm for AgNPs prepared with 5 mL, 10 mL and 20 mL of Cz-extract, respectively. AgNPs release kinetic was studied by Korsmeyer-Peppas model. The antimicrobial results revealed that the PVA/PGLD-AgNPs hydrogels showed good antibacterial activity behavior against Escherichia coli.

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Nanomedicine for Maternal and Fetal Health

Carter,

Better,

Abbasi

et al. 2023

Small

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Conception, pregnancy, and childbirth are complex processes that affect both mother and fetus. Thus, it is perhaps not surprising that in the United States alone, roughly 11% of women struggle with infertility and 16% of pregnancies involve some sort of complication. This presents a clear need to develop safe and effective treatment options, though the development of therapeutics for use in women's health and particularly in pregnancy is relatively limited. Physiological and biological changes during the menstrual cycle and pregnancy impact biodistribution, pharmacokinetics, and efficacy, further complicating the process of administration and delivery of therapeutics. In addition to the complex pharmacodynamics, there is also the challenge of overcoming physiological barriers that impact various routes of local and systemic administration, including the blood–follicle barrier and the placenta. Nanomedicine presents a unique opportunity to target and sustain drug delivery to the reproductive tract and other relevant organs in the mother and fetus, as well as improve the safety profile and minimize side effects. Nanomedicine‐based approaches have the potential to improve the management and treatment of infertility, obstetric complications, and fetal conditions.

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Biosynthesized silver nanoparticles (using Cinnamomum zeylanicum bark extract) improve the fertility status of rats with polycystic ovarian syndrome

Cited by 15 publications

References 40 publications

Long Term Oral Administration of Oregano Essence Effectively Relieves Polycystic Ovarian Rats through Endocrine and Inflammatory Balance

Long Term Oral Administration of Oregano Essence Effectively Relieves Polycystic Ovarian Rats through Endocrine and Inflammatory Balance

Poly(vinyl alcohol)/poly(glycerol) dendrimer hydrogel mediated green synthesis of silver nanoparticles

Nanomedicine for Maternal and Fetal Health

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