Biotechnological Applications of Bioactive Peptides From Marine Sources

Giordano, Daniela; Costantini, Maria; Coppola, Daniela; Lauritano, Chiara; Pons, Laura Núñez; Ruocco, Nadia; Prisco, Guido di; Ianora, Adrianna; Verde, Cinzia

doi:10.1016/bs.ampbs.2018.05.002

Cited by 84 publications

(87 citation statements)

References 243 publications

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“…Microalgae, and in particular diatoms, therefore, can be considered potentially important producers of compounds to prevent and treat different human pathologies. In recent years they have been shown to have anti-inflammatory, antimicrobial, anticancer, antidiabetic, antiepileptic and even antituberculosis properties [10][11][12][49][50][51][52][53][54][55]. A better understanding of the potential health benefits from these marine organisms, the compounds they produce, and the environmental conditions affecting their production should allow for the sustainable development of these valuable marine resources in the future.…”

Section: Discussionmentioning

confidence: 99%

Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity

et al. 2020

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Microalgae have been shown to be excellent producers of lipids, pigments, carbohydrates, and a plethora of secondary metabolites with possible applications in the pharmacological, nutraceutical, and cosmeceutical sectors. Recently, various microalgal raw extracts have been found to have anti-inflammatory properties. In this study, we performed the fractionation of raw extracts of the diatom Cylindrotheca closterium, previously shown to have anti-inflammatory properties, obtaining five fractions. Fractions C and D were found to significantly inhibit tumor necrosis factor alpha (TNF-⍺) release in LPS-stimulated human monocyte THP-1 cells. A dereplication analysis of these two fractions allowed the identification of their main components. Our data suggest that lysophosphatidylcholines and a breakdown product of chlorophyll, pheophorbide a, were probably responsible for the observed anti-inflammatory activity. Pheophorbide a is known to have anti-inflammatory properties. We tested and confirmed the anti-inflammatory activity of 1-palmitoyl-sn-glycero-3-phosphocholine, the most abundant lysophosphatidylcholine found in fraction C. This study demonstrated the importance of proper dereplication of bioactive extracts and fractions before isolation of compounds is commenced.

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Section: Discussionmentioning

confidence: 99%

Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity

et al. 2020

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“…Such findings indicate that the chemistry of toxin production in dinoflagellates is very complex and requires in depth new studies in both the ecological and drug discovery fields in order to identify novel chemical mediators in the marine environment and new lead compounds that can be developed as pharmaceuticals. Microalgae have already shown to have several bioactivities for the treatment of human pathologies, such as anticancer, anti-inflammatory, anti-diabetes, antioxidant, anti-tuberculosis, anti-epilepsy, anti-hypertensive, anti-atherosclerosis and anti-osteoporosis activities [95,[125][126][127][128]. In particular, Alexandrium minutum has been shown to be active on human lung cancer cells [129], Alexandrium andersoni induces cell death in lung and colorectal tumour cell lines [130], while Alexandrium tamutum was active on human melanoma cell lines [17].…”

Section: Discussionmentioning

confidence: 99%

De novo Transcriptome of the Non-saxitoxin Producing Alexandrium tamutum Reveals New Insights on Harmful Dinoflagellates

et al. 2020

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Many dinoflagellates species, especially of the Alexandrium genus, produce a series of toxins with tremendous impacts on human and environmental health, and tourism economies. Alexandrium tamutum was discovered for the first time in the Gulf of Naples, and it is not known to produce saxitoxins. However, a clone of A. tamutum from the same Gulf showed copepod reproduction impairment and antiproliferative activity. In this study, the full transcriptome of the dinoflagellate A. tamutum is presented in both control and phosphate starvation conditions. RNA-seq approach was used for in silico identification of transcripts that can be involved in the synthesis of toxic compounds. Phosphate starvation was selected because it is known to induce toxin production for other Alexandrium spp. Results showed the presence of three transcripts related to saxitoxin synthesis (sxtA, sxtG and sxtU), and others potentially related to the synthesis of additional toxic compounds (e.g., 44 transcripts annotated as “polyketide synthase”). These data suggest that even if this A. tamutum clone does not produce saxitoxins, it has the potential to produce toxic metabolites, in line with the previously observed activity. These data give new insights into toxic microalgae, toxin production and their potential applications for the treatment of human pathologies.

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“…Marine microalgae produce a huge number of metabolites with biological activity [63], including anticancer [64,65], anti-microbial [66], immunomodulatory [67], anti-diabetes [68], anti-tuberculosis [69], anti-epilepsy [70], anti-hypertensive, anti-atherosclerosis, anti-osteoporosis [71], and anti-inflammatory [20,72] activities. Even if microalgae are characterized by a huge biodiversity and amount of secondary metabolites, in the last 10 years, only a small number of studies reported antiviral activity of microalgal compounds (Table 3).…”

Section: Marine Microalgaementioning

confidence: 99%

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

et al. 2020

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Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.

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Biotechnological Applications of Bioactive Peptides From Marine Sources

Cited by 84 publications

References 243 publications

Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity

Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity

De novo Transcriptome of the Non-saxitoxin Producing Alexandrium tamutum Reveals New Insights on Harmful Dinoflagellates

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

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