Biotechnological applications of mangrove plants and their isolated compounds in medicine-a mechanistic overview

Sadeer, Nabeelah Bibi; Zengin, Gökhan; Mahomoodally, Mohamad Fawzi

doi:10.1080/07388551.2022.2033682

Cited by 17 publications

(13 citation statements)

References 100 publications

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“…Meskipun beberapa hasil kajian sudah menunjukkan kerugian ekonomi yang besar jika penebangan hutan termasuk mangrove tidak terkontrol dan terus menerus dilakukan. Ekosistem mangrove menyediakan jasa lingkungan yang besar bagi masyarakat seperti penyediaan hasil-hasil laut lewat fungsinya sebagai daerah hunian, asuhan dan pembesaran berbagai hewan-hewan laut bernilai ekonomis (Uddin et al, 2019); merupakan sumber kayu untuk bahan bangunan dan kayu bakar yang dapat dimanfaatkan oleh masyarakat, serta bahan baku obat-obatan tradisional (Sadeer et al, 2022;Palacios and Cantera, 2017;Alongi, 2002); melindungi daratan pantai dari bahaya lingkungan seperti kejadian abrasi, tsunami, gelombang tinggi, serta perubahan iklim global (Tagaki, 2019;Spalding et al, 2014;Alongi, 2008). Hilangnya hutan mangrove tentunya juga akan menghilangkan layanan ekosistemnya yang besar diantaranya seperti yang telah diuraikan di atas dan jika kehilangan ini dikonversi ke dalam rupiah maka kerugian ekonomi yang bisa dialami oleh masyarakat sangat besar dengan hilangnya mangrove.…”

Section: Tantangan Kelembagaanunclassified

Rehabilitasi Kawasan Pesisir untuk Mitigasi Perubahan Iklim: Peranan mangrove dan penurunan emisi tingkat sub-nasional

D.¹,

R.²

2022

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areal mangrove dan kategorisasinya 2.2 Aspek hukum dan kelembagaan 3 Komitmen Rehabilitasi/Restorasi Mangrove 4 Peluang dan Tantangan Rehabilitasi dan Restorasi Mangrove 4.1 Nilai ekonomi karbon biru 4.2 Tantangan kelembagaan 4.3 Tantangan ekologis 5 Rekomendasi 6 Penutup Daftar Pustaka iv Daftar tabel dan gambarTabel 1 Luas areal mangrove di dalam dan di luar kawasan hutan dan kondisinya berdasarkan Peta Mangrove Nasional 2 Luas mangrove "eksisting" menurut kategori kerapatan tajuk 3 Luas "potensi" habitat mangrove menurut kategori penggunaan lahan 4 Luas mangrove "eksisting" dan "potensi" habitat mangrove di dalam dan di luar kawasan hutan Gambar 1 Capaian rehabilitasi mangrove dengan dana publik selama 7 tahun terakhir sejak RPJMN 2015-2019 dimulai.vi Kata PengantarProgram rehabilitasi/restorasi mangrove dalam skala besar di Indonesia telah menarik perhatian banyak pihak di dalam maupun di luar negeri. Hal ini terjadi sehubungan dengan volume pekerjaan dan waktu yang tersedia untuk melaksanakannya. Untuk menangkap aspirasi publik yang terkait dengan program ini, sebuah webinar diselenggarakan pada tanggal 31 Maret 2022. Webinar tersebut membahas 3 aspek utama: strategi jangka panjang pengelolaan kawasan pesisir, kawasan pesisir untuk mitigasi perubahan iklim dan kawasan pesisir untuk adaptasi perubahan iklim.Dokumen ini secara ringkas menyoroti peluang dan tantangan memasukkan kawasan pesisir ke dalam agenda mitigasi perubahan iklim. Melalui konsultasi dengan peserta webinar yang dirangkum oleh Menteri Koordinator Bidang Maritim dan Investasi, terdapat catatan khusus terkait dengan pengalaman dan tingkat kesuksesan selama dua RPJMN terakhir sebagai pertimbangan dalam pelaksanaan rehabilitasi mangrove besar-besaran di Indonesia.Catatan lain juga diberikan dalam kaitannya dengan implikasi kelembagaan dan ekologis program rehabilitasi/restorasi serta pentingnya melibatkan pemerintah daerah untuk mempersiapkan kebijakan nilai ekonomi karbon di tingkat sub-nasional. Tantangan dan kendala yang diidentifikasi webinar sangat umum namun komprehensif untuk dijadikan pertimbangan.Harapan kami, dokumen yang dapat dikatakan sebagai langkah awal dari penilaian rencana program rehabilitasi/restorasi ini juga dapat dikembangkan sesuai dengan dinamika yang terjadi di lapangan dan pengalaman yang dipelajari oleh para pemangku kepentingan. Kami menyadari beberapa kekurangan dan kelemahan di dalamnya, namun kerjasama yang baik antar pemangku kepentingan akan memperbaiki kualitas penilaian selanjutnya.

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Section: Tantangan Kelembagaanunclassified

Rehabilitasi Kawasan Pesisir untuk Mitigasi Perubahan Iklim: Peranan mangrove dan penurunan emisi tingkat sub-nasional

D.¹,

R.²

2022

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“…Microbes such as bacteria, actinomycetes, and fungi are the principal sources of xylanase enzymes, which can be employed for industrial applications. Bacterial xylanases can tolerate extreme conditions of temperature and pH, making them well suited for industrial uses 11–13 . Also, applications that require enzymes in bulk quantities can employ fungal xylanases, as fungus can liberate extracellular xylanases in extraordinary amounts in the surrounding culture medium 14–16 .…”

Section: Introductionmentioning

confidence: 99%

“…Bacterial xylanases can tolerate extreme conditions of temperature and pH, making them well suited for industrial uses. [11][12][13] Also, applications that require enzymes in bulk quantities can employ fungal xylanases, as fungus can liberate extracellular xylanases in extraordinary amounts in the surrounding culture medium. [14][15][16] Microbial xylanases being ecofriendly have served as safer substitutes for bleaching chemicals used in pulp and paper industry in order to reduce the risk of environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

An insight into microbial sources, classification, and industrial applications of xylanases: A rapid review

Kaur

Joshi

Sharma

et al. 2023

Biotech and App Biochem

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Endo 1,4‐β‐d‐xylanases (EC3.2.1.8) are one of the key lignocellulose hydrolyzing enzymes. Xylan, which is present in copious amounts on earth, forms the primary substrate of endo‐xylanases, which can unchain the constituent monosaccharides linked via β‐1,4‐glycosidic bonds from the xylan backbone. Researchers have shown keen interest in the xylanases belonging to glycoside hydrolase families 10 and 11, whereas those placed in other glycoside hydrolase families are yet to be investigated. Various microbes such as bacteria and fungi harbor these enzymes for the metabolism of their lignocellulose fibers. These microbes can be used as miniature biofactories of xylanase enzymes for a plethora of environmentally benign applications in pulp and paper industry, biofuel production, and for improving the quality of food in bread baking and fruit juice industry. This review highlights the potential of microbes in production of xylanase for industrial biotechnology.

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“…( B. gymnorhiza ). Despite decoctions (leaves and roots) of this plant being the most commonly used mangrove species to control DM type 2 both globally and locally [ 3 ], it lacks pharmacological validation. In our previous paper, the organic extracts of B. gymnorhiza were screened [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Mangroves are considered an important medicinal plant based on their salient history in the medical lore. Apart from DM, the different plant parts of B. gymnorhiza can also be used against diarrhoea, fever, eye diseases, haemorrhage, liver disorders, shingles, or to treat burns, stings from toxic lagoon fishes and even to remove intestinal worms [ 3 , 8 , 9 , 10 , 11 ]. Herbs and natural products are rich in medicinal ingredients, and their therapeutic healing properties have been known since ancient times.…”

Section: Introductionmentioning

confidence: 99%

Towards the Pharmacological Validation and Phytochemical Profiling of the Decoction and Maceration of Bruguiera gymnorhiza (L.) Lam.—A Traditionally Used Medicinal Halophyte

et al. 2022

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Decoctions (leaves and roots) of Bruguiera gymnorhiza (L.) Lam. are traditionally used against diabetes in many countries, including Mauritius. This study endeavoured to evaluate the inhibitory potential of leaves, roots, twigs and fruits extracts (decoction and maceration) of B. gymnorhiza against key enzymes relevant to diabetes. Considering complications related to diabetes, other clinical enzymes, namely, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, elastase and pancreatic lipase, were used. Identification of compounds was carried out using ultra-high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS). Antioxidant capacities were assessed using DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum, metal chelating. The relationship between mode of extraction, plant parts and biological activities was determined using multivariate analysis. Macerated fruits, rich in phytochemicals (phenolic, flavanol, tannin, and triterpenoid), exhibited substantially high antioxidant capacities related to radical scavenging (DPPH: 547.75 ± 10.99 and ABTS: 439.59 ± 19.13 mg TE/g, respectively) and reducing potential (CUPRAC: 956.04 ± 11.90 and FRAP: 577.26 ± 4.55 mg TE/g, respectively). Additionally, the same extract significantly depressed AChE and BChE (3.75 ± 0.03 and 2.19 ± 0.13 mg GALAE/g, respectively), tyrosinase (147.01 ± 0.78 mg KAE/g), elastase (3.14 ± 0.08 mg OE/g) and amylase (1.22 ± 0.01 mmol ACAE/g) enzymatic activities. Phytochemical results confirmed the presence of 119 compounds in all maceration and 163 compounds in all decoction samples. The screening also revealed important compounds in the extracts, namely, quinic acid, brugierol, bruguierol A, epigallocatechin, chlorogenic acid, to name a few. Multivariate analysis reported that the plant parts of B. gymnorhiza greatly influenced the observed biological activities in contrast to the types of extraction methods employed. Docking calculations have supported the findings of the experimental part through the high binding affinity and strong interactions of some compounds against tyrosinase, AChE, BChE and elastase enzymes. The decocted root and leaf of B. gymnorhiza showed low to moderate antidiabetic activity, thereby partially supporting its traditional uses in the management of diabetes. However, the fruit, the most active organ, can be used as a diet supplement to reduce the risk of diabetes complications after evaluating its cytotoxic effects.

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Biotechnological applications of mangrove plants and their isolated compounds in medicine-a mechanistic overview

Cited by 17 publications

References 100 publications

Rehabilitasi Kawasan Pesisir untuk Mitigasi Perubahan Iklim: Peranan mangrove dan penurunan emisi tingkat sub-nasional

Rehabilitasi Kawasan Pesisir untuk Mitigasi Perubahan Iklim: Peranan mangrove dan penurunan emisi tingkat sub-nasional

An insight into microbial sources, classification, and industrial applications of xylanases: A rapid review

Towards the Pharmacological Validation and Phytochemical Profiling of the Decoction and Maceration of Bruguiera gymnorhiza (L.) Lam.—A Traditionally Used Medicinal Halophyte

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