Biotechnological Innovations and Therapeutic Application of Pediococcus and Lactic Acid Bacteria: The Next-Generation Microorganism

Abstract

Lactic acid bacteria represent a worthwhile organism within the microbial consortium for the food sector, health, and biotechnological applications. They tend to offer high stability to environmental conditions, with an indicated increase in product yield, alongside their moderate antimicrobial activity. Lack of endotoxins and inclusion bodies, extracellular secretion, and surface display with other unique properties, are all winning attributes of these Gram-positive lactic acid bacteria, of which, Pediococcus is progressively becoming an attractive and promising host, as the next-generation probiotic comparable with other well-known model systems. Here, we presented the biotechnological developments in Pediococcal bacteriocin expression system, contemporary variegated models of Pediococcus and lactic acid bacteria strains as microbial cell factory, most recent applications as possible live delivery vector for use as therapeutics, as well as upsurging challenges and future perspective. With the radical introduction of artificial intelligence and neural network in Synthetic Biology, the microbial usage of lactic acid bacteria as an alternative eco-friendly strain, with safe use properties compared with the already known conventional strains is expected to see an increase in various food and biotechnological applications in years to come as it offers better hope of safety, accuracy, and higher efficiency.

Effects of the alpine meadow in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

“…Pediococcus belongs to the family Lactobacillaceae , and is also considered a safe lactic acid bacterium. It plays an important function in preserving various facets of human fact, such as the nutrient digestion and absorption, resistance against pathogens, and immune system [ 16 ], that indicating yak gains more nutrients and energy with the alpine meadow regreen. Three genera were enriched as microbial biomarkers in the GP group, including Prevotella , Bacteroidales_UCG_001 , and UCG_004 .…”

Effects of the grass in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

“…Pediococcus belongs to the family Lactobacillaceae, and is also considered a safe lactic acid bacteria. It plays an important function in preserving various facets of human fact, such as the nutrient digestion and absorption, resistance against pathogens, and immune system [15], indicating yak gains more nutrients and energy with the grass regreen. Three genera were enriched as microbial biomarkers in the GP group, including Prevotella, Bacteroidales_UCG_001, and UCG_004.…”

Fusarium biocontrol: antagonism and mycotoxin elimination by lactic acid bacteria

“…This finding supported pre-existing speculation that the main removal mechanism is physical adsorption by cell wall peptidoglycan and polysaccharides rather than biodegradation. Biotreatment of malting wheat grains with a suspension of bacteria culture containing Pediococcus pentosaceus strains greatly affected the mycotoxin content of grains, especially TCT contamination ( Juodeikiene et al, 2018 ; Peter et al, 2022 ). Instead of exhibiting a direct absorption ability, some strains act as probiotics and reduce the impairment caused by mycotoxins.…”