Biotechnological production of vanillin

Havkin‐Frenkel, Daphna; Belanger, Faith C.

doi:10.1002/9781118354056.ch5

Cited by 12 publications

(10 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, only vanillin can be produced via a commercial process by oxidation of lignosulfonates, a byproduct from the sulfite pulping industry [121,122,123]. Recently, new chemical and biotechnological approaches for the production of vanillin are studied [23,120,124,125,126]. Starting from vanillin, many biobased aromatic monomers for polyester synthesis can be produced, for example, vanillic acid, divanillyl diol, dimethyl divanillate, and so on [127,128,129,130,131].…”

Section: Biobased Monomers For Polyester and Polyamide Synthesismentioning

confidence: 99%

Enzymatic Synthesis of Biobased Polyesters and Polyamides

2016

View full text Add to dashboard Cite

Nowadays, "green" is a hot topic almost everywhere, from retailers to universities to industries; and achieving a green status has become a universal aim. However, polymers are commonly considered not to be "green", being associated with massive energy consumption and severe pollution problems (for example, the "Plastic Soup") as a public stereotype. To achieve green polymers, three elements should be entailed: (1) green raw materials, catalysts and solvents; (2) eco-friendly synthesis processes; and (3) sustainable polymers with a low carbon footprint, for example, (bio)degradable polymers or polymers which can be recycled or disposed with a gentle environmental impact. By utilizing biobased monomers in enzymatic polymerizations, many advantageous green aspects can be fulfilled. For example, biobased monomers and enzyme catalysts are renewable materials that are derived from biomass feedstocks; enzymatic polymerizations are clean and energy saving processes; and no toxic residuals contaminate the final products. Therefore, synthesis of renewable polymers via enzymatic polymerizations of biobased monomers provides an opportunity for achieving green polymers and a future sustainable polymer industry, which will eventually play an essential role for realizing and maintaining a biobased and sustainable society.

show abstract

Section: Biobased Monomers For Polyester and Polyamide Synthesismentioning

confidence: 99%

Enzymatic Synthesis of Biobased Polyesters and Polyamides

2016

View full text Add to dashboard Cite

show abstract

“…32,36,37 Other promising substrates include glucose, 38,39 and lignin fragments. 31 The Belgian specialty chemical company Solvay, a leading producer of synthetic vanillin after its purchase of Rhodia, makes "natural" vanillin from ferulic acid. 17 The process, originally developed by Givaudan and exclusively licensed to Rhodia, involves the fermentation of this substrate by bacteria.…”

Section: ■ Introductionmentioning

confidence: 99%

Vanillin Production from Lignin and Its Use as a Renewable Chemical

Fache

Boutevin

Caillol

2015

ACS Sustainable Chem. Eng.

737

577

View full text Add to dashboard Cite

The use of vanillin as a building block for the chemical industry is discussed in this article. Vanillin is currently one of the only molecular phenolic compounds manufactured on an industrial scale from biomass. It has thus the potential to become a key-intermediate for the synthesis of bio-based polymers, for which aromatic monomers are needed to reach good thermo-mechanical properties. After a first part dedicated to the current sourcing of vanillin, this article focuses on the alkaline oxidation lignin-to-vanillin process, reporting advantages and limits, discusses the various postdepolymerization methods for product isolation and finally examines the outlook for the wider use of vanillin as a key building block for the chemical industry.

show abstract

“…Aromatic aldehydes are important molecules in an industrial context, as they can be used as chemical building blocks and have major applications in the flavors industry, especially benzaldehyde and vanillin [43,44]. Furthermore, some aromatic aldehydes can be produced from lignin, a major component of plant biomass, therefore providing an alternative sustainable source for these key chemical building blocks away from fossilderived sources [45].…”

Section: Introductionmentioning

confidence: 99%

Directed evolution of the PcaV allosteric transcription factor to generate a biosensor for aromatic aldehydes

Machado

Currin

Dixon

2019

Preprint

View full text Add to dashboard Cite

Background:Genetically encoded biosensors are useful tools for the detection of metabolites and industrially valuable molecules, and present many potential applications in biotechnology and biomedicine. However, the most common approach to develop biosensors relies on employing a limited set of naturally occurring allosteric transcript factors (aTFs). Therefore, altering the substrate specificity of aTFs towards the detection of new effectors is an important goal. Results:Here, the PcaV repressor, a member of the MarR aTF family, was used to develop a biosensor for the detection of hydroxyl-substituted benzoic acids, including protocatechuic acid (PCA). The PCA biosensor was further subjected to directed evolution to alter its substrate specificity towards vanillin and other closely related aromatic aldehydes, to generate the Van2 biosensor. Substrate recognition of Van2 was explored in vitro using a range of biochemical and biophysical analyses, and extensive in vivo genetic-phenotypic analysis was performed to determine the role of each amino acid change upon biosensor performance. Conclusions:This is the first study to report directed evolution of a member of the MarR aTF family, and demonstrates the plasticity of the PCA biosensor by altering its substrate specificity to generate a biosensor for aromatic aldehydes.

show abstract

Biotechnological production of vanillin

Cited by 12 publications

References 64 publications

Enzymatic Synthesis of Biobased Polyesters and Polyamides

Enzymatic Synthesis of Biobased Polyesters and Polyamides

Vanillin Production from Lignin and Its Use as a Renewable Chemical

Directed evolution of the PcaV allosteric transcription factor to generate a biosensor for aromatic aldehydes

Contact Info

Product

Resources

About