Bioterrorism: New Technologies for Global Emergencies and Public Health

Mugavero, Roberto; Sabato, Valentina; Basso, Matteo; D’Amico, Wanda; Benolli, Federico

doi:10.1080/15536548.2015.1105658

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Such mutants can form naturally. In addition, current situation in the world [5] does not make it possible to rule out a variant when the advent of such mutants might result from structures engaged in bioterrorist activity. In such situations, drastic measures to eliminate CTC would be justified.…”

Section: розроблено просторово-динамIчну модель що описує структуру mentioning

confidence: 99%

Development of a spatialdynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes

Vуsotska

Georgiyants

Nosov

et al. 2018

EEJET

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Section: розроблено просторово-динамIчну модель що описує структуру mentioning

confidence: 99%

Development of a spatialdynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes

Vуsotska

Georgiyants

Nosov

et al. 2018

EEJET

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“…Bacterial infections of B. anthracis are primarily relegated to wild and domestic herbivores, with occasional spillover to humans (Carlson et al, , ; De Vos, van Heerden, & Turner, ). B. anthracis has also garnered global attention as a bioterrorism weapon due to the highly resilient qualities of its endospores and their ability to be aerosolized for malicious purposes (Koehler & Popella, ; Mugavero, Sabato, Basso, D’Amico, & Benolli, ). Virulence in B. anthracis is dependent on the chromosome, (>5,200,000 base pairs (bp) in length) and two large plasmids: pXO1 (>180,000 bp) and pXO2 (>90,000 bp).…”

Section: Introductionmentioning

confidence: 99%

A classification framework for Bacillus anthracis defined by global genomic structure

Bruce

Schiraldi

Kamath

et al. 2020

Evolutionary Applications

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Evolutionary Applications. 2020;13:935-944. | 935 wileyonlinelibrary.com/journal/eva | INTRODUC TI ONBacillus anthracis is a Gram-positive, rod-shaped bacterium and worldwide clonal zoonotic pathogen, best known as the etiologic agent of anthrax. Bacterial infections of B. anthracis are primarily relegated to wild and domestic herbivores, with occasional spillover to humans (Carlson et al., 2018(Carlson et al., , 2019De Vos, van Heerden, & Turner, 2018). B. anthracis has also garnered global attention as a bioterrorism weapon due to the highly resilient qualities of its endospores and their ability to be aerosolized for malicious purposes AbstractBacillus anthracis, the causative agent of anthrax, is a considerable global health threat affecting wildlife, livestock, and the general public. In this study, whole-genome sequence analysis of over 350 B. anthracis isolates was used to establish a new highresolution global genotyping framework that is both biogeographically informative and compatible with multiple genomic assays. The data presented in this study shed new light on the diverse global dissemination of this species and indicate that many lineages may be uniquely suited to the geographic regions in which they are found.In addition, we demonstrate that plasmid genomic structure for this species is largely consistent with chromosomal population structure, suggesting vertical inheritance in this bacterium has contributed to its evolutionary persistence. This classification methodology is the first based on population genomic structure for this species and has potential use for local and broader institutions seeking to understand both disease outbreak origins and recent introductions. In addition, we provide access to a newly developed genotyping script as well as the full whole-genome sequence analyses output for this study, allowing future studies to rapidly employ and append their data in the context of this global collection. This framework may act as a powerful tool for public health agencies, wildlife disease laboratories, and researchers seeking to utilize and expand this classification scheme for further investigations into B. anthracis evolution. K E Y W O R D S Bacillus anthracis, bacterial pathogen, genotyping, global diversity, phylogenomics, population genomics, whole-genome sequencing S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Bruce SA, Schiraldi NJ, Kamath PL, Easterday WR, Turner WC. A classification framework for Bacillus anthracis defined by global genomic structure. Evol Appl. 2020;13:935-944. https ://doi.

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“…anthracis are primarily relegated to wild and domestic herbivores, with occasional spillover to humans (Carlson et al, 2018;de Vos et al, 2018). B. anthracis has also garnered global attention as a bioterrorism weapon due to the highly resilient qualities of its endospores, and their ability to be aerosolized for malicious purposes (Mugavero et al, 2015;Koehler & Popella, 2018).…”

Section: Introductionmentioning

confidence: 99%

A classification framework forBacillus anthracisdefined by global genomic structure

Bruce

Schiraldi

Kamath

et al. 2019

Preprint

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Bacillus anthracis, the causative agent of anthrax, is a considerable global health threat affecting wildlife, livestock, and the general public. In this study whole-genome sequence analysis of over 350 B. anthracis isolates was used to establish a new high-resolution global genotyping framework that is both biogeographically informative, and compatible with multiple genomic assays. The data presented in this study shed new light on the diverse global dissemination of this species and indicate that many lineages may be uniquely suited to the geographic regions in which they are found. In addition, we demonstrate that plasmid genomic structure for this species is largely consistent with chromosomal population structure, suggesting vertical inheritance in this bacterium has contributed to its evolutionary persistence. This classification methodology is the first based on population genomic structure for this species and has potential use for local and broader institutions seeking to understand both disease outbreak origins and recent introductions. In addition, we provide access to a newly developed genotyping script as well as the full whole genome sequence analyses output for this study, allowing future studies to rapidly employ and append their data in the context of this global collection. This framework may act as a powerful tool for public health agencies, wildlife disease laboratories, and researchers seeking to utilize and expand this classification scheme for further investigations into B. anthracis evolution.

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Bioterrorism: New Technologies for Global Emergencies and Public Health

Cited by 4 publications

References 2 publications

Development of a spatialdynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes

Development of a spatialdynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes

A classification framework for Bacillus anthracis defined by global genomic structure

A classification framework forBacillus anthracisdefined by global genomic structure

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Bioterrorism: New Technologies for Global Emergencies and Public Health

Cited by 4 publications

References 2 publications

Development of a spatial­dynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes

Development of a spatial­dynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes

A classification framework for Bacillus anthracis defined by global genomic structure

A classification framework forBacillus anthracisdefined by global genomic structure

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Development of a spatialdynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes

Development of a spatialdynamical model of the structure of clumps of toxic cyanobacteria for biosafty purposes