Biotinidase: its role in biotinidase deficiency and biotin metabolism

Wolf, Barry

doi:10.1016/j.jnutbio.2005.03.024

Cited by 44 publications

(28 citation statements)

References 32 publications

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“…However, other studies indicate that there are no major differences on any vitamin content under different fertilizer dosages in both natural and agricultural environments (Brandt et al 2011). Besides, meta-analyses of organic fertilization and its effects on vitamin content, especially under organic production practices, report few well-controlled studies capable of making valid comparisons or classify these as insufficiently documented (Mozafar 1994;Woese et al 1997;Bourn and Prescott 2002;Hunter et al 2011). It should be noted that most field studies only evaluate a limited number of vitamins; actually, the most commonly analyzed are b-carotene, ascorbate and tocopherols (vitamins A, C and E).…”

Section: Variation In Vitamin Contentsmentioning

confidence: 99%

Plant amino acid-derived vitamins: biosynthesis and function

Miret

Munné‐Bosch

2013

Amino Acids

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Vitamins are essential organic compounds for humans, having lost the ability to de novo synthesize them. Hence, they represent dietary requirements, which are covered by plants as the main dietary source of most vitamins (through food or livestock's feed). Most vitamins synthesized by plants present amino acids as precursors (B1, B2, B3, B5, B7, B9 and E) and are therefore linked to plant nitrogen metabolism. Amino acids play different roles in their biosynthesis and metabolism, either incorporated into the backbone of the vitamin or as amino, sulfur or one-carbon group donors. There is a high natural variation in vitamin contents in crops and its exploitation through breeding, metabolic engineering and agronomic practices can enhance their nutritional quality. While the underlying biochemical roles of vitamins as cosubstrates or cofactors are usually common for most eukaryotes, the impact of vitamins B and E in metabolism and physiology can be quite different on plants and animals. Here, we first aim at giving an overview of the biosynthesis of amino acid-derived vitamins in plants, with a particular focus on how this knowledge can be exploited to increase vitamin contents in crops. Second, we will focus on the functions of these vitamins in both plants and animals (and humans in particular), to unravel common and specific roles for vitamins in evolutionary distant organisms, in which these amino acid-derived vitamins play, however, an essential role.

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Section: Variation In Vitamin Contentsmentioning

confidence: 99%

Plant amino acid-derived vitamins: biosynthesis and function

Miret

Munné‐Bosch

2013

Amino Acids

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“…35,36 This notion is consistent with the classical role of biotinidase as a biotin-ε-lysine hydrolase. 37 The hydrolysis of the biotin-ε-lysine bond by biotinidase is a reversible reaction and the equilibrium can be shifted toward the binding of biotin to histones by providing high concentrations of biotin-ε-lysine in vitro. 6,38 …”

Section: Debiotinylation Of Histonesmentioning

confidence: 99%

The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

Zempleni

Xue

et al. 2011

Epigenetics

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“…In humans, the vitamin biotin is an essential micronutrient that has two different functions in the cell (Wolf 2001(Wolf , 2005. First, it is the cofactor of five biotin-carboxylases: pyruvate carboxylase (EC 6.4.1.1), propionyl-CoA carboxylase (EC 6.4.1.3), methylcrotonyl-CoA carboxylase (EC 6.4.1.4), and two forms of acetyl-CoA carboxylase (EC 6.4.1.2), 1 and 2.…”

Section: Concerning Enzymatic and Genetic Findingsmentioning

confidence: 99%

Evaluation of the biotinidase activity in hepatic glycogen storage disease patients. Undescribed genetic finding associated with atypical enzymatic behavior: an outlook

Angaroni

Giner-Ayala

Hill

et al. 2010

J of Inher Metab Disea

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Repeated evaluation of biotinidase (BTD) activity was carried out for a long-term follow-up in patients with hepatic glycogen storage diseases (GSDs). The results indicated inter-intra variability among the GSD-Ia, GSD-III and GSD-IX patients. In addition, a c.1330G>C transversion in the BTD gene, resulting in a p.Asp444His substitution was detected in one allele of a GSD-Ia patient with sustained normal enzyme activity. Thus far, it is necessary to be cautious in the interpretation of the results of BTD activity as a presumptive GSD diagnostic element. It is not known why plasma BTD activity increases in GSDs patients, or the clinical importance of the increment. When viewed from a global perspective, there are some lines of biotin biology that could indicate a relationship between BTD´s behavior and GSDs.

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Biotinidase: its role in biotinidase deficiency and biotin metabolism

Cited by 44 publications

References 32 publications

Plant amino acid-derived vitamins: biosynthesis and function

Plant amino acid-derived vitamins: biosynthesis and function

The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

Evaluation of the biotinidase activity in hepatic glycogen storage disease patients. Undescribed genetic finding associated with atypical enzymatic behavior: an outlook

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