Biotinylated selenocyanates: Potent and selective cytostatic agents

First Generation of Antioxidant Precursors for Bioisosteric Se-NSAIDs: Design, Synthesis, and In Vitro and In Vivo Anticancer Evaluation

“…The efficacy of selenocompounds as anticancer agents is correlated with their metabolic route, dose, and the chemical form of Se [ 5 , 18 ]. Hence, the main Se entities that have been widely explored to date are selenides [ 19 , 20 , 21 , 22 ], selenocyanates [ 22 , 23 , 24 , 25 , 26 ], isoselenocyanates [ 27 , 28 , 29 ], selenazo heterocyclic compounds [ 13 , 30 , 31 ], selenoesters [ 32 , 33 , 34 ], selenoureas [ 35 , 36 , 37 , 38 , 39 ], and diselenides [ 19 , 22 , 23 , 24 , 25 , 39 , 40 ]. Additionally, several compounds bearing these functionalities have also been reported to have a potent radical scavenging capacity, allowing the design of molecules with an interesting dual profile as antioxidant and antiproliferative agents [ 19 , 25 , 37 , 38 ].…”

“…Hence, the main Se entities that have been widely explored to date are selenides [19][20][21][22], selenocyanates [22][23][24][25][26], isoselenocyanates [27][28][29], selenazo heterocyclic compounds [13,30,31], selenoesters [32][33][34], selenoureas [35][36][37][38][39], and diselenides [19,[22][23][24][25]39,40]. Additionally, several compounds bearing these functionalities have also been reported to have a potent radical scavenging capacity, allowing the design of molecules with an interesting dual profile as antioxidant and antiproliferative agents [19,25,37,38].…”

Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies

“…1) do not compromise its affinity for BRs. 29 Herein, we describe the design, synthesis and evaluation of a new series of sulfonamides derived from biotin, as a cancer-targeting scaffold.…”