Biotransformation and bioconcentration of 6:2 and 8:2 polyfluoroalkyl phosphate diesters in common carp (Cyprinus carpio): Underestimated ecological risks

Chen, Meng; Guo, Tingting; He, Keyan; Zhu, Lingyan; Jin, Hangbiao; Wang, Qiang; Liu, Meilin; Yang, Liping

doi:10.1016/j.scitotenv.2018.11.297

Cited by 38 publications

(31 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the detection of PFOA in the elimination water supported this conclusion (Figure 3A). Interestingly, PFHpA was almost never measured above LOQ levels during the uptake period but was quantifiable at trace levels after depuration, in agreement with findings from a previous study (Chen et al 2019a). We did not detect PFNA, a result also consistent with those of Butt et al (2010b), who found that PFNA was formed at much lower concentrations than PFOA; therefore, the absence of PFNA was reasonable.…”

Section: Biotransformation Products and Mass Balancesupporting

confidence: 92%

“…The accumulation of each metabolite compound in mussels appeared to be tissue specific (p < 0.05). The present study found that 7:3 FTCA was the major product in the adductor muscle, gonad, gills, and digestive gland, whereas PFOA was The intermediates in the solid rectangular boxes were detected, the dotted arrows show the approach proposed in the previous study (Fasano et al 2006;Zabaleta et al 2017;Chen et al 2019a), and the solid arrows show the pathway verified in the present study. FTAL = fluorotelemer aldehyde; FTOH = fluorotelemer alcohol; FTUAL = fluorotelomer unsaturated aldehyde.…”

Section: Biotransformation Products and Mass Balancesupporting

confidence: 76%

“…Based on this, the concentrations of 8:2 diPAP were relatively steady in the digestive gland (13550-13964 ng/g dry wt), the whole body (4160-4289 ng/g dry wt), and the gonad (239-249 ng/g dry wt) at the end of the uptake phase, with the value of the relative standard deviation being <20%, thus suggesting that a steadystate 8:2 diPAP level in these organs was achieved, whereas other organs (the mantle, gills, and adductor muscle) did not reach steady state within 72 h of exposure. Chen et al (2019a) reported that 8:2 diPAP did not reach steady-state liver concentration within 14 d of water-borne exposure in carp (Cyprinus carpio), at a similar exposure level, 7.9 μg/L (2 nM). This finding further highlights species-specific differences in PFAS accumulation.…”

Section: Tissue Distributionmentioning

confidence: 94%

“…To date, the accumulation potential and biotransformation pathways of 8:2 diPAP in aquatic organisms have been investigated in fish (Zabaleta et al 2017;Chen et al 2019aChen et al , 2019b and worms (Chen et al 2019b). Bivalves are common aquatic organisms with high filter-feeding activity, a relatively long life span, and an ability to tolerate chemical exposure and organic pollutants (Bonnail et al 2016).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

Cui

Tan

Chen

et al. 2021

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Although the distribution of 8:2 polyfluoroalkyl phosphate diester (8:2 diPAP) in aquatic environments has been reported, details on its uptake, tissue specificity, and elimination in bivalve mollusks remain to be clarified. The present study is the first report on the accumulation and elimination of 8:2 diPAP in mussels (Mytilus galloprovincialis). The tissue-specific accumulation and depuration of 8:2 diPAP and its metabolites were investigated via semistatic seawater exposure (8:2 diPAP at a nominal concentration of 10 μg/L), through water-borne exposure with static daily renewal over a 72-h exposure period and a 360-h depuration period. The digestive gland was found to be the target organ where accumulation and biotransformation primarily occur. The bioaccumulation factor values (mL/g dry wt) in different organs were in the following order: digestive gland (1249) > adductor muscle (315) > gills (289) > gonad (82.9) > mantle (33.0). Moreover, the distribution of 8:2 diPAP among tissues may be related to the total protein content. The 8:2 diPAP tended to be excreted in feces. The compounds 8:2 fluorotelomer carboxylic acid, 8:2 fluorotelomer unsaturated carboxylic acid, 7:3 fluorotelomer carboxylic acid, perfluorooctanoic acid, and perfluoroheptanoic acid were detected and quantified as phase I metabolites, and the concentration of all phase I metabolites relative to the 8:2 diPAP concentration (72 h) was 0.304 mol%. A phase II metabolite, 8:2 fluorotelomer alcohol conjugated with sulfate, was detected but not quantitated in the digestive gland. A biotransformation pathway of 8:2 diPAP in M. galloprovincialis was proposed on the basis of the results obtained in the present study and previous studies. These findings improve our understanding of the accumulation of perfluorocarboxylic acids in bivalve mollusks.

show abstract

Section: Biotransformation Products and Mass Balancesupporting

confidence: 92%

Section: Biotransformation Products and Mass Balancesupporting

confidence: 76%

Section: Tissue Distributionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

Cui

Tan

Chen

et al. 2021

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…PAPs were not determined in the US blood donors. The biotransformation of diPAPs has been studied in Carp (Chen et al 2019 ). Several metabolites were detected but not the corresponding PAPs.…”

Section: Discussionmentioning

confidence: 99%

Per- and polyfluoroalkyl substances (PFASs) in Swedish household dust and exposure of pet cats

Weiss

Jones

Koekkoek

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

Per- and polyfluoroalkyl substances (PFASs) are used in a wide range of products and have been found ubiquitously in our indoor environment, and there is evidence that exposure to PFAS can lead to adverse endocrine effects, such as thyroid hormone disruption. Pet cats have a high dust intake due to their grooming behavior and have been shown to be a suitable sentinel species for assessment of toddler’s exposure. Here we used paired household dust (n=46) and cat serum (n=27) samples to establish whether dust is a relevant exposure pathway to PFASs. An analytical method for PFAS analysis was optimized using a low volume of cat serum samples, combining solid-phase extraction and online sample cleanup. Dust was extracted with methanol by sonication and cleaned up by addition of active carbon. In total, 27 PFASs were analyzed by liquid chromatography/mass spectrometry analysis. The correlation between PFAS levels in dust and serum, serum lipids and thyroid hormone levels, and PFAS levels in dust between different rooms were statistically evaluated. PFOS and PFDA could be quantified in all cat serum samples (median 2300 pg/mL and 430 pg/mL, respectively), followed by PFOA (median 1100 pg/mL), quantified in 96% of the samples. The levels of 6:2 and 8:2 diPAPs were determined in 65% and 92% of the serum samples, respectively, and were an order of magnitude lower (1.4–160 pg/mL). Household dust on the other hand was dominated by 6:2 and 8:2 diPAPs, with a median of 65 ng/g dust and 49 ng/g dust, respectively. PFOS (median 13 ng/g dust) and PFOA (median 9 ng/g dust) were quantified in 93% of the dust samples. Only eight PFASs were detected (>LOD) in at least 50% of the samples of both matrices and could be paired. Significant correlations between cat serum and dust were found for PFOA (rS=0.32, p<0.049) and PFUnDA (rS=0.55, p<0.001). Significant positive correlations were found between serum total thyroxine (rS=0.11, p<0.05) and PFNA and between serum cholesterol and PFHpA (rS=0.46, p<0.01), PFUnDA (rS=0.40, p<0.05), PFDoDA (rS=0.44, p<0.01), and sum PFAS (rS=0.48, p<0.01). In conclusion, this study confirmed that dust is a relevant exposure pathway for the ingestion of some PFASs for cats, and the serum levels of PFASs could be of relevance for the cat’s health.

show abstract

New insights into the oxidative damage and antioxidant defense mechanism in Manila clams (Ruditapes philippinarum) exposed to 8:2 polyfluoroalkyl phosphate diester stress

et al. 2023

View full text Add to dashboard Cite

Biotransformation and bioconcentration of 6:2 and 8:2 polyfluoroalkyl phosphate diesters in common carp (Cyprinus carpio): Underestimated ecological risks

Cited by 38 publications

References 51 publications

Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

Per- and polyfluoroalkyl substances (PFASs) in Swedish household dust and exposure of pet cats

New insights into the oxidative damage and antioxidant defense mechanism in Manila clams (Ruditapes philippinarum) exposed to 8:2 polyfluoroalkyl phosphate diester stress

Contact Info

Product

Resources

About