Biotransformation and metabolism of three methyl salicylate glycosides by gut microbiota in vitro

Dong, Ying; Li, Xiao; Zhao, Yicheng; Ren, Xueyang; Zheng, Yuan; Song, Ruolan; Zhong, Xiangjian; Shan, Dongjie; Lv, Fang; Deng, Qingyue; Li, Xianxian; He, Yingyu; Chai, Kequn; Wang, Xiuhuan; She, Gaimei

doi:10.1016/j.jpba.2023.115474

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Methyl heptenone contributes to the synthesis of ionone and citral, being of great significance as a pharmaceutical intermediate [34]. Methyl salicylate serves as a precursor for acetylsalicylic acid synthesis [35]. Moreover, n-hexanal can be utilized as a plasticizer, an organic synthetic component in rubber and resin, an insecticide, and an edible flavoring [36].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Floral Scent Component of Three Iris Species at Different Stages

Cai,

Ban,

et al. 2024

Horticulturae

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The research investigates the variations in floral scent composition among different species and developmental stages of Iris plants: Iris uniflora, Iris typhifolia, and Iris sanguinea. The study analyzes the fragrance components by utilizing electronic nose technology in tandem with headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). Principal component analysis (PCA), linear discriminant analysis (LDA), and loading analysis are applied to discern whether floral scents of the same Iris species at distinct stages could be differentiated. The results show that the electronic nose significantly distinguishes the aromas from different stages and that there are differences in aroma composition. Gas Chromatography-Mass Spectrometry confirms significant differences in volatile components regarding the three Iris species, with common compounds like alcohols, aromatics, and aldehydes present throughout stages. Notably, nonyl aldehyde, capric aldehyde, 2,4-di-tert-butylphenol, and n-heptadecane are consistently found. Cluster analysis reveals a grouping of decay stage samples of Iris typhifolia and Iris sanguinea due to terpene and ester abundance. Nonyl aldehyde significantly contributes to the aroma profiles of all species, owing to its high odor activity value. The significant content of volatile compounds in these Iris varieties suggests economic and medicinal potential beyond ornamental value, providing references for the development of Iris-scented products, aromatherapy, and the extraction of pharmacologically active substances from Iris.

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Section: Discussionmentioning

confidence: 99%

Analysis of Floral Scent Component of Three Iris Species at Different Stages

Cai,

Ban,

et al. 2024

Horticulturae

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“…MSTG-A, MSTG-B and Gaultherin isolated from Dianbaizhu, which is an ECM with the effect of “ Qufengchushi , Qingrejiedu , Huoxuehuayu ” 13 , 17 . They carried out good anti-inflammatory and analgesic activity with a structural parent nucleus similar to aspirin 16 , 23 . As we know, anti-inflammatory and immunomodulatory therapeutic strategies have been a major focus in the treatment of SCZ in recent years 11 , 79 , 80 .…”

Section: Discussionmentioning

confidence: 99%

“…We determined its medicinal active part and isolated its main active ingredients (methyl salicylate glycoside components, MSGs), named as MSTG-A, MSTG-B and Gaultherin, respectively, all of which have been reported to have anti-inflammatory and analgesic effects 14 , 15 . Their chemical structure differs only in the position and number of glucose and xylose substitutions, and they have been shown to interconvert in vivo and in vitro 16 , 17 . Eventually, they are present in the animal in the form of their metabolites, salicylic acid or methyl salicylate 17 , 18 .…”

Section: Introductionmentioning

confidence: 99%

Exploration on the potential efficacy and mechanism of methyl salicylate glycosides in the treatment of schizophrenia based on bioinformatics, molecular docking and dynamics simulation

Wang,

Ma,

Dong

et al. 2024

Schizophr

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The etiological and therapeutic complexities of schizophrenia (SCZ) persist, prompting exploration of anti-inflammatory therapy as a potential treatment approach. Methyl salicylate glycosides (MSGs), possessing a structural parent nucleus akin to aspirin, are being investigated for their therapeutic potential in schizophrenia. Utilizing bioinformation mining, network pharmacology, molecular docking and dynamics simulation, the potential value and mechanism of MSGs (including MSTG-A, MSTG-B, and Gaultherin) in the treatment of SCZ, as well as the underlying pathogenesis of the disorder, were examined. 581 differentially expressed genes related to SCZ were identified in patients and healthy individuals, with 349 up-regulated genes and 232 down-regulated genes. 29 core targets were characterized by protein-protein interaction (PPI) network, with the top 10 core targets being BDNF, VEGFA, PVALB, KCNA1, GRIN2A, ATP2B2, KCNA2, APOE, PPARGC1A and SCN1A. The pathogenesis of SCZ primarily involves cAMP signaling, neurodegenerative diseases and other pathways, as well as regulation of ion transmembrane transport. Molecular docking analysis revealed that the three candidates exhibited binding activity with certain targets with binding affinities ranging from −4.7 to −109.2 kcal/mol. MSTG-A, MSTG-B and Gaultherin show promise for use in the treatment of SCZ, potentially through their ability to modulate the expression of multiple genes involved in synaptic structure and function, ion transport, energy metabolism. Molecular dynamics simulation revealed good binding abilities between MSTG-A, MSTG-B, Gaultherin and ATP2B2. It suggests new avenues for further investigation in this area.

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