Biotransformation of 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine (TTBP-TAZ) can contribute to high levels of 2,4,6-tribromophenol (2,4,6-TBP) in humans

Assessment of the contamination by 2,4,6-tribromophenol of marine waters and organisms exposed to chlorination discharges

“…This indicated that human health should not be affected by TBP contamination of marine biota in the industrial Gulf of Fos. However, some recent studies revealed its strong endocrine disrupting potential (Leonetti et al, 2016 ;Zheng et al, 2022), and cocktail effects should be considered (Lebaron et al, 2019). Therefore, further research is clearly required to refine the human toxicological values for TBP and to evaluate potential impacts to human health.…”

“…TBP was found in all environmental compartments, ambient and indoor air, soil, sediment, marine and freshwater, as well as in their related biota (Koch and Sures, 2018;Bidleman et al, 2019;Jia et al, 2020;Michalowicz et al, 2022). The incidence of TBP produced by human activities is receiving a growing concern, as an increasing number of studies demonstrates its high toxicity to aquatic and terrestrial organisms, and potentially to humans, mainly resulting in neurological, reproductive, developmental effects and endocrine disruption (Deng et al, 2010;ECHA, 2016;Koch and Sures, 2018;Knudsen et al, 2019;Lebaron et al, 2019;Zheng et al, 2022;Zhou et al, 2023).…”