Biotransformation of acridine by Mycobacterium vanbaalenii

Abstract

Cultures of Mycobacterium vanbaalenii strain PYR-1 in a liquid medium were exposed to the toxic environmental contaminant acridine (260 microM). After incubation for 7 d, the cultures were extracted with ethyl acetate. Metabolites were purified using high-performance liquid chromatography and analyzed by mass spectrometry and 1H nuclear magnetic resonance spectroscopy. Four metabolites, 9,10-dihydroacridine, 4-hydroxyacridine, acridine cis-1 ,2-dihydrodiol, and acridin-9(10H)-one, were identified.

Impact of nitrogen-polycyclic aromatic hydrocarbons on phenanthrene and benzo[a]pyrene mineralisation in soil

“…Exploitation of the biodegradative capabilities of microorganisms for the clean-up of contaminated land has become widely accepted as an alternative to both physical and chemical methods because of its comparatively low cost and environmental sustainability (Sayer and Ripp, 2000;Sutherland et al, 2009;Doley et al, 2017;Menga et al, 2017;Li et al, 2017). Polycyclic aromatic hydrocarbons (PAHs) are among the most abundant organic contaminants with a potential to be degraded.…”

10.17686/sced_rusnauka_2014-1382

“…LH128 превращали акридин (C) в акридин-9-он (CIII) (Van Herwijnen et al, 2004). Трансформация акридина (C) растущими клетками Mycobacterium vanbaalenii strain PYR-1 в течение 7 суток сопровождалась образованием четырех метаболитовакридин цис-1,2-дигидродиола (CIb, выход 1.1%), 4гидроксиакридина (CIV, выход 5.4%), акридин-9-она (CIII выход 1.1%), и 9,10-дигидроакридина (CV, выход 55.2%) (Sutherland et al, 2009):…”