Biotransformation of alkaloids

Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review

“…The biotransformation of alkaloids by microbes and plants was recently reviewed by Rathbone et al [45,46] , in which they provide a summary of the progress of alkaloid biotransformations from mid-1980s to 2002. It is difficult to modify structures of alkaloids because of the complex polycyclic nature of these compounds.…”