Biotransformation of arsenic and toxicological implication of arsenic metabolites

Hirano, Seishiro

doi:10.1007/s00204-020-02772-9

Cited by 50 publications

(35 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the As metalloid is well known to pose high health risks and remains highly carcinogenic. In fact, it is a very notable carcinogen understood to cause cancer following gastrointestinal or respiratory exposure [64][65][66]. Exposure to As was believed to have led to cancers of the skin, lungs, and bladder, according to the International Agency for Research on Cancer [67].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Detection, Distribution and Health Risk Assessment of Toxic Heavy Metals/Metalloids, Arsenic, Cadmium, and Lead in Goat Carcasses Processed for Human Consumption in South-Eastern Nigeria

Njoga

Ezenduka

Ogbodo

et al. 2021

Foods

View full text Add to dashboard Cite

Notwithstanding the increased toxic heavy metals/metalloids (THMs) accumulation in (edible) organs owed to goat′s feeding habit and anthropogenic activities, the chevon remains increasingly relished as a special delicacy in Nigeria. Specific to the South-Eastern region, however, there is paucity of relevant data regarding the prevalence of THMs in goat carcasses processed for human consumption. This work was, therefore, aimed to investigate the detection, distribution and health risk assessment of THMs in goat carcass processed for human consumption in South-Eastern Nigeria. To achieve this, a total of 450 meat samples (kidney, liver and muscle) were evaluated from 150 randomly selected goat carcasses processed in two major slaughterhouses in Enugu State. The detection, distribution, as well as health risk assessment parameters followed standard procedures. Results revealed that at least one THM was detected in 56% of the carcasses. Mean concentrations of arsenic (As) were 0.53 ± 0.10 mg/kg, 0.57 ± 0.09 mg/kg and 0.45 ± 0.08 mg/kg, lead (Pb) were 0.48 ± 0.38 mg/kg, 0.45 ± 0.24 mg/kg and 0.82 ± 0.39 mg/kg, cadmium (Cd) was 0.06 ± 0.32 mg/kg, 0.02 ± 0.00 mg/kg, and 0.02 ± 0.00 mg/kg for kidney, liver and muscle tissues, respectively. The estimated daily intakes (EDI) for all THMs were above the recommended safe limits. The target hazard quotient (THQ) and hazard index (HI) computed for all As, Cd and Pb fell below unity in all the studied organs, which indicated no non-carcinogenic risks. Curtailing the anthropogenic activities that aid the THM-contamination in goat production/processing lines is recommended. Screening for THM-contamination in Nigerian slaughterhouses is imperative, so as to ascertain the toxicological safety of meats intended for human consumption.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Examples include the induction of chromosome abnormalities, oxidative stress, altered DNA repair and altered DNA methylation patterns [65,67]. Monomethylarsonic acid, which is a major product of biomethylation of arsenic, is crucial in the arsenic-induced carcinogenesis [1,66,68].…”

Section: Discussionmentioning

confidence: 99%

Detection, Distribution and Health Risk Assessment of Toxic Heavy Metals/Metalloids, Arsenic, Cadmium, and Lead in Goat Carcasses Processed for Human Consumption in South-Eastern Nigeria

Njoga

Ezenduka

Ogbodo

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…It is known that As III undergoes a series of redox methylation reactions in vivo to form As V , and diverse methylated metabolites (Cullen, 2014). Meanwhile, given the fact that the different arsenic metabolites have unique therapeutic or toxicologic potentials (Khaleghian et al, 2014;Khairul et al, 2017;Hirano, 2020). Thus, there has been growing recognition that elucidates the pharmacokinetics of diverse plasma arsenic metabolites level was more critical for the Data were expressed as mean ± SEM, n 6.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, when i.v. or oral administration, arsenite (As III , the hydrolyzed form of ATO) is subjected to sequential reduction and oxidative methylation reactions in the blood to form arsenate (As V ), monomethylated arsenic (MMA), and dimethylated arsenic (DMA) (Cullen, 2014;Hirano, 2020). Previously, the methylation metabolism of arsenic was described as a detoxification process.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, the methylation metabolism of arsenic was described as a detoxification process. However, more recent evidence has established that the intermediate metabolites of arsenic, trivalent forms of MMA and DMA (MMA III , DMA III ), are more toxic than inorganic arsenic (iAs, including As III and As V ) (Khairul et al, 2017;Hirano, 2020). Trivalent arsenicals show high binding affinity to thiol groups of free cysteine residues, leading to structural modifications of proteins as well as enzyme inhibition (Shen et al, 2013;Soria et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetic Characteristics, Tissue Bioaccumulation and Toxicity Profiles of Oral Arsenic Trioxide in Rats: Implications for the Treatment and Risk Assessment of Acute Promyelocytic Leukemia

et al. 2021

View full text Add to dashboard Cite

Oral arsenic trioxide (ATO) has demonstrated a favorable clinical efficiency in the treatment of acute promyelocytic leukemia (APL). However, the pharmacokinetic characteristics, tissue bioaccumulation, and toxicity profiles of arsenic metabolites in vivo following oral administration of ATO have not yet been characterized. The present study uses high performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) to assess the pharmacokinetics of arsenic metabolites in rat plasma after oral and intravenous administration of 1 mg kg−1 ATO. In addition, the bioaccumulation of arsenic metabolites in blood and selected tissues were evaluated after 28 days oral administration of ATO in rats at a dose of 0, 2, 8, and 20 mg kg−1 d−1. The HPLC-HG-AFS analysis was complemented by a biochemical, hematological, and histopathological evaluation conducted upon completion of ATO treatment. Pharmacokinetic results showed that arsenite (AsIII) reached a maximum plasma concentration rapidly after initial dosing, and the absolute bioavailability of AsIII was 81.03%. Toxicological results showed that the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and white blood cells (WBC) in the 20 mg kg−1 d−1 ATO group were significantly increased compared to the control group (p < 0.05). The distribution trend of total arsenic in the rat was as follows: whole blood > kidney > liver > heart. Dimethylated arsenic (DMA) was the predominant bioaccumulative metabolite in the whole blood, liver, and heart, while monomethylated arsenic (MMA) was the predominant one in the kidney. Collectively, these results revealed that oral ATO was rapidly absorbed, well-tolerated, and showed organ-specific and dose-specific bioaccumulation of arsenic metabolites. The present study provides preliminary evidence for clinical applications and the long-term safety evaluation of oral ATO in the treatment of APL.

show abstract

Metallomics in Toxicology

Wang,

Gao,

Chen

et al. 2024

Applied Metallomics

View full text Add to dashboard Cite

Biotransformation of arsenic and toxicological implication of arsenic metabolites

Cited by 50 publications

References 167 publications

Detection, Distribution and Health Risk Assessment of Toxic Heavy Metals/Metalloids, Arsenic, Cadmium, and Lead in Goat Carcasses Processed for Human Consumption in South-Eastern Nigeria

Detection, Distribution and Health Risk Assessment of Toxic Heavy Metals/Metalloids, Arsenic, Cadmium, and Lead in Goat Carcasses Processed for Human Consumption in South-Eastern Nigeria

Pharmacokinetic Characteristics, Tissue Bioaccumulation and Toxicity Profiles of Oral Arsenic Trioxide in Rats: Implications for the Treatment and Risk Assessment of Acute Promyelocytic Leukemia

Metallomics in Toxicology

Contact Info

Product

Resources

About