Biotransformation of exogenous substrates by plant cell cultures

Suga, Takayuki; Hirata, Toshifumi

doi:10.1016/0031-9422(90)85155-9

Cited by 176 publications

(59 citation statements)

References 73 publications

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“…Recently, the biotransformation of exogenous substrates by cultured plant cells has been reported (Suga et al 1990;Ishihara et al 2003). The cultured plant cells have the abilities of hydroxylation, glycosylation, oxido-reduction, hydrogenation, and hydrolysis for various organic compounds.…”

mentioning

confidence: 99%

Regioselective hydroxylation, reduction, and glycosylation of diphenyl compounds by cultured plant cells of Eucalyptus perriniana

Kondo

Shimoda

Miyahara

et al. 2006

Plant Biotechnology

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mentioning

confidence: 99%

Regioselective hydroxylation, reduction, and glycosylation of diphenyl compounds by cultured plant cells of Eucalyptus perriniana

Kondo

Shimoda

Miyahara

et al. 2006

Plant Biotechnology

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“…One example is the convertion of foreign substances in the stereo-and regioselective control of organic synthesis. 4,5) However, to our knowledge, there has been no study on the decomposition of BPA by means of plant-cultured cells. We have been investigating oxidation by using plant-cultured cells.…”

mentioning

confidence: 99%

Biodegradation of Bisphenol A by Cultured Cells ofCaragana chamlagu

Chai

Sakamaki

Kitanaka

et al. 2003

Bioscience, Biotechnology, and Biochemistry

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“…[1][2][3][4][5][6] The microbial reduction enables preparation of optically pure alcohols and helps to lessen the environmental impact of organic syntheses. For example, the asymmetric reduction of keto esters by bakers' yeast has been widely used to obtain chiral compounds, because the produced hydroxy esters are useful chiral building blocks for the synthesis of natural and bioactive compounds.…”

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confidence: 99%

Purification and Characterization of Two α-Keto Ester Reductases fromStreptomyces thermocyaneoviolaceusIFO 14271

Yamaguchi

Nakajima²,

Ishihara

2002

Bioscience, Biotechnology, and Biochemistry

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Two NADPH-dependent a-keto ester reductases (Streptomyces thermocyaneoviolaceus keto ester reductase, STKER-II and -III) were puriˆed from S. thermocyaneoviolaceus IFO 14271, one of thermophilic actinomycetes. The molecular masses of native STKER-II and -III were estimated to be 60 kDa and 70 kDa by gel ltration chromatography, respectively. These enzymes were both homodimers, with 29-kDa and 30-kDa subunit molecular masses based on SDS polyacrylamide gel electrophoresis. STKER-II and -III were stable from pH 7.0 to 10.0 and pH 5.5 to 9.0, respectively. Ethyl 3-methyl-2-oxobutanoate was reduced by both enzymes isolated to the corresponding (R)-hydroxy ester with excellent enantiomeric excess. STKER-III showed high stereoselectivity for the reduction of bulky substrates, while the selectivity of the STKER-II-catalyzed reduction was low except for ethyl 3-methyl-2-hydroxybutanoate. Both enzymes had small K m values toward aliphatic keto esters having a long alkyl chain.

show abstract

Biotransformation of exogenous substrates by plant cell cultures

Cited by 176 publications

References 73 publications

Regioselective hydroxylation, reduction, and glycosylation of diphenyl compounds by cultured plant cells of Eucalyptus perriniana

Regioselective hydroxylation, reduction, and glycosylation of diphenyl compounds by cultured plant cells of Eucalyptus perriniana

Biodegradation of Bisphenol A by Cultured Cells ofCaragana chamlagu

Purification and Characterization of Two α-Keto Ester Reductases fromStreptomyces thermocyaneoviolaceusIFO 14271

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