Biotransformation of furanocoumarins by Cunninghamella elegans

Attia, Ghada; Abou-El-seoud, Kamillia A.; Ibrahim, Abdel-Rahim S.

doi:10.1016/j.bfopcu.2014.09.001

Cited by 4 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural coumarins are widely distributed in at least 13 plant families, including Rutaceae, Umbelliferae, Asteraceae, and Leguminosae. XAT is most abundant in the fruit of the Rutaceae pepper and the roots of the Umbelliferae Oxalis, which is also found in small amounts in animal and microbial metabolites (Attia, Abou‐El‐Seoud, & Ibrahim, 2015; Gao et al, 2021). Coumarins are lactones with the basic structure of benzoɑ‐pyrone and can be broadly grouped into four major groups according to the substituents and benzene rings on the parent nucleus of coumarins, namely, simple coumarins, furanocoumarins, pyranocoumarins, and other coumarins (Ben Salem, Jabrane, Harzallah‐Skhiri, & Ben Jannet, 2013).…”

Section: Introductionmentioning

confidence: 99%

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Zhong

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

Xanthotoxin (XAT) is a natural furanocoumarins, a bioactive psoralen isolated from the fruit of the Rutaceae plant Pepper, which has received increasing attention in recent years due to its wide source and low cost. By collecting and compiling literature on XAT, the results show that XAT exhibits significant activity in the treatment of various diseases, including neuroprotection, skin repair, osteoprotection, organ protection, anticancer, antiinflammatory, antioxidative stress and antibacterial. In this paper, we review the pharmacological activity and potential molecular mechanisms of XAT for the treatment of related diseases. The data suggest that XAT can mechanistically induce ROS production and promote apoptosis through mitochondrial or endoplasmic reticulum pathways, regulate NF‐κB, MAPK, JAK/STAT, Nrf2/HO‐1, MAPK, AKT/mTOR, and ERK1/2 signaling pathways to exert pharmacological effects. In addition, the pharmacokinetics properties and toxicity of XAT are discussed in this paper, further elucidating the relationship between structure and efficacy. It is worth noting that data from clinical studies of XAT are still scarce, limiting the use of XAT in the clinic, and in the future, more in‐depth studies are needed to determine the clinical efficacy of XAT.

show abstract

Section: Introductionmentioning

confidence: 99%

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Zhong

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

Biological importance of bioactive phytochemical ‘Cimifugin’ as potential active pharmaceutical ingredients against human disorders: A natural phytochemical for new therapeutic alternatives

Patel¹

2023

Pharmacological Research - Modern Chinese Medicine

View full text Add to dashboard Cite

Biotransformation of two furanocoumarins by the fungi species Aspergillus sp. PTCC 5266 and Aspergillus niger PTCC 5010

Ghasemi

Habibi

Mohajeri

et al. 2018

Natural Product Research

View full text Add to dashboard Cite

The microbial transformations of peucedanin and oreoselon by the fungi Aspergillus niger and Aspergillus sp. were investigated for the first time. Incubation of peucedanin with A. niger yielded a new hydroxylated metabolite with high yield (56%), which was characterized as 2-(1-hydroxypropan-2-yl)-3-methoxy-7H-furo[3,2-g]chromen-7-one. Oreoselon was converted to a new reduced metabolite methyl 3-(2,3-dihydro-6-hydroxy-2-isopropyl-3-oxobenzofuran-5-yl)propanoate in biotransformation by Aspergillus sp. The structures of the metabolites were determined by spectroscopic methods including IR, EI-MS, H NMR,C NMR, and elemental analysis.

show abstract

Biotransformation of furanocoumarins by Cunninghamella elegans

Cited by 4 publications

References 7 publications

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Biological importance of bioactive phytochemical ‘Cimifugin’ as potential active pharmaceutical ingredients against human disorders: A natural phytochemical for new therapeutic alternatives

Biotransformation of two furanocoumarins by the fungi species Aspergillus sp. PTCC 5266 and Aspergillus niger PTCC 5010

Contact Info

Product

Resources

About