Biotransformation of Meloxicam by Cunninghamella blakesleeana: Significance of Carbon and Nitrogen Source

Prasad, G. Shyam; Rao, K. N.; Rama, Preethi; Girisham, S.; Reddy, S. M.

doi:10.1007/s12088-011-0099-0

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…It is the main composition of DNA, protein and acts as a building block of the cells. Recently, in the biotransformation studies of meloxicam by Cunninghamella blakesleeana , the nitrogen source was varied and it was found that ammonium nitrate was most suitable for efficient production (Prasad et al 2011 ).…”

Section: Resultsmentioning

confidence: 99%

“…Glucose is the most preferred carbohydrate in fermentative processes and, therefore, addition of glucose at a particular concentration can help in the increased activity of the organism and thus elevated production (Prasad et al 2011 ). Also, supplementation of different carbon sources can have various effects on the morphology, biomass and production of metabolites in fungus (Jia et al 2009 ).…”

Section: Resultsmentioning

confidence: 99%

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Standardization of medium composition and agricultural waste in the production of p-hydroxybenzoic acid by Paecilomyces variotii

et al. 2014

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Biotransformation of p-coumaric acid by Paecilomyces variotii resulted in the accumulation of a metabolite which was identified as p-hydroxybenzoic acid. We studied the possibility of enhancing this metabolite by various parameters such as varying the concentration of substrate, addition of different nitrogen sources and carbon sources at varying concentration and use of different agricultural wastes as a nutritive medium. Maximum amount of 254.6 ± 9.34 mg/kg of p-hydroxybenzoic acid was detected in the solid medium of corncob on 4th day of incubation using 10 mM p-coumaric acid as a sole carbon source. Consequently, P. variotii can be used as candidate fungi for the production of p-hydroxybenzoic acid. Solid wastes can be managed by using them for biotransformation of pharmaceutically important phenolic acids and hence cut down the cost of production of value-added compounds using a low-cost medium.Electronic supplementary materialThe online version of this article (doi:10.1007/s13205-014-0262-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Standardization of medium composition and agricultural waste in the production of p-hydroxybenzoic acid by Paecilomyces variotii

et al. 2014

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“…Microbial transformation could yield novel drugs and existing drugs could be modified so as to increase activity and decrease toxicity. Sometimes, by modification of the parent drug, its side-effects could be reduced and the stability could be increased [13]. Cunninghamella blakesleeana NRRL 1369 has P450 monooxygenase.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Microbial Transformation of Pimavanserin by Cunninghamella blakesleeana AS 3.970

Song,

Yu,

Liu

et al. 2023

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Pimavanserin is an approved selective 5-HT2A receptor inverse agonist for treating Parkinson’s disease psychosis. However, few studies on its metabolism in vitro have been investigated. In this research, eight strains of fungi are used to study the pimavanserin metabolism profiles in vitro and six of them demonstrated positive transformation results. Factors influencing the transformation rate, like substrate concentration, culture time, initial media pH value, culture temperature, and shaking speed, were evaluated and optimized. Cunninghamella blakesleeana AS3.970 provided the best transformation rate of 30.31%, and 10 unreported metabolites were screened by LC-MS/MS. Among these metabolites, M1 is the major one and identified as 1-(4-fluorobenzyl)-3-(4-(2-hydroxy-2-methylpropoxy)benzyl)-1-(1-methylpiperidin-4-yl)urea, which is a hydroxylation product of the pimavanserin. A preliminary molecular docking simulation was performed, which indicated that M1 exhibits similar binding properties with pimavanserin and may become a potential candidate for Parkinson’s disease treatment.

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Chromatographic analysis of meloxicam and metabolites of its biodegradation

et al. 2022

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Biotransformation of Meloxicam by Cunninghamella blakesleeana: Significance of Carbon and Nitrogen Source

Cited by 4 publications

References 24 publications

Standardization of medium composition and agricultural waste in the production of p-hydroxybenzoic acid by Paecilomyces variotii

Standardization of medium composition and agricultural waste in the production of p-hydroxybenzoic acid by Paecilomyces variotii

Microbial Transformation of Pimavanserin by Cunninghamella blakesleeana AS 3.970

Chromatographic analysis of meloxicam and metabolites of its biodegradation

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