Biotransformation of α-terpineol by Alternaria alternata

Abstract

a-Terpineol (1), the main volatile constituent in some traditional Chinese medicines, has been reported to be metabolized to 4R-oleuropeic acid by the larvae of common cutworms. The present study verified that a-terpineol could be converted to 4R-oleuropeic acid (2) and (1S,2R,4R)-p-menthane-1,2,8-triol (3) by Alternaria alternata fermentation. Using shortened fermentation times, 7-hydroxy-a-terpineol (2a) was identified as an oxidative intermediate, which was consistent with the hypothesis put forward by previous studies. Cytochrome P450 enzymes were also confirmed to catalyze this biotransformation. This is the first study on the biotransformation of a-terpineol by microbial fermentation. Fig. 1 The biotransformation of 1 by Alternaria alternate.

Intraspecific Variation in the Terpene Profiles of Dodonaea viscosa

“…This mixture was subjected to a transesterification reaction with K 2 CO 3 in methanol. This afforded previously reported monoterpenoid 7 c [29] (Figure 5) and a mixture of two fatty acid methyl esters. GC-MS analysis revealed two peaks with masses m/z 354 ( The NMR spectroscopic, MS and optical rotation data associated with monoterpene 7 c were in agreement with equivalent data reported for this compound {lit.…”

“…GC-MS analysis revealed two peaks with masses m/z 354 ( The NMR spectroscopic, MS and optical rotation data associated with monoterpene 7 c were in agreement with equivalent data reported for this compound {lit. [29] [α] D 25 À 25.1 (c 0.020, CHCl 3 )}. [29,30] Unusual terpene wax esters 4 a and 4 b represent first in class monoterpenoid wax esters.…”

“…[29] [α] D 25 À 25.1 (c 0.020, CHCl 3 )}. [29,30] Unusual terpene wax esters 4 a and 4 b represent first in class monoterpenoid wax esters. Indeed, only a handful of natural products isolation studies have reported the isolation of terpene wax esters.…”

Biotransformation of 1,8-Dihydroxyanthraquinone into Peniphenone under the Fermentation of Aleurodiscus mirabilis

“… 5 Our previous studies have shown that microbial autogenic metabolic processes and many transformations have been achieved by microorganisms. 6 − 11 …”

“…Biotransformation shows great advantages compared with chemical synthesis due to its regio- and stereoselectivity, environmentally friendly procedures, and mild reaction conditions. , In general, biotransformations can replace a multistep synthesis with a single microbial transformation. , Therefore, bioconversion could play a critical role in the synthesis of bioactive compounds . Our previous studies have shown that microbial autogenic metabolic processes and many transformations have been achieved by microorganisms. − …”