Biotransformations by Colletotrichum species

García-Pajón, Carlos Mario; Hernández-Galán, Rosario; Collado, Isidro G.

doi:10.1016/s0957-4166(03)00223-4

Cited by 57 publications

(3 citation statements)

References 35 publications

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“…may explain how these pathogens detoxify phytoalexins [ 91 ] and why these fungi have been investigated for their capacity to biotransform various products (e.g. terpenoids) [ 92 ]. The PKS genes and clusters are most abundant within Colletotrichum spp.…”

Section: Discussionmentioning

confidence: 99%

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

et al. 2016

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BackgroundMany species belonging to the genus Colletotrichum cause anthracnose disease on a wide range of plant species. In addition to their economic impact, the genus Colletotrichum is a useful model for the study of the evolution of host specificity, speciation and reproductive behaviors. Genome projects of Colletotrichum species have already opened a new era for studying the evolution of pathogenesis in fungi.ResultsWe sequenced and annotated the genomes of four strains in the Colletotrichum acutatum species complex (CAsc), a clade of broad host range pathogens within the genus. The four CAsc proteomes and secretomes along with those representing an additional 13 species (six Colletotrichum spp. and seven other Sordariomycetes) were classified into protein families using a variety of tools. Hierarchical clustering of gene family and functional domain assignments, and phylogenetic analyses revealed lineage specific losses of carbohydrate-active enzymes (CAZymes) and proteases encoding genes in Colletotrichum species that have narrow host range as well as duplications of these families in the CAsc. We also found a lineage specific expansion of necrosis and ethylene-inducing peptide 1 (Nep1)-like protein (NLPs) families within the CAsc.ConclusionsThis study illustrates the plasticity of Colletotrichum genomes, and shows that major changes in host range are associated with relatively recent changes in gene content.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-2917-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

et al. 2016

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“…Penz & Sacc. (teleomorph Glomerella cingulata), C. lini and C. musae (Berkeley et Curtis) von Arx, have been used in biotransformations (15)(16)(17). However, the ability of C. acutatum to produce microbial transformations has been scarcely investigated, although this species was recently shown being involved in bioconversion processes to produce 2-PE from acetophenone (18).…”

Section: Introductionmentioning

confidence: 99%

PRODUCTION OF 2-PHENYLETHANOL IN THE BIOTRANSFORMATION OF CINNAMYL ALCOHOL BY THE PLANT PATHOGENIC FUNGUS <I>Colletotrichum acutatum</I>

et al. 2010

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Biocatalytic processes may offer a cheaper alternative to natural production of flavours. The biotransformation of cinnamyl alcohol is investigated using the plant pathogenic fungus Colletotrichum acutatum as a biocatalyst. Results show that substrate is converted to 3-phenyl-1-propanol, 1-phenyl-1,3- propanediol, 2-phenylethanol, 1-phenyl-1,2-ethanediol, 3-phenyl propyl acetate, and hydrocinnamic acid. The structures of the metabolic products are elucidated on the basis of their spectral data. 2-phenylethanol has a sweet, floral odor and a wide variety of applications, especially, for the perfume and food industries. A time-course experiment demonstrates that 2-phenylethanol appeared after 120 hours, reaching almost 8% of relative abundance. Additionally, the influence that the culture broth has on the conversion capacity is investigated. It has been discovered that cinnamyl alcohol is converted faster when the substrate is incorporated in a Sabouraud medium; under this condition, 2-phenylethanol is the most common product after 288 hours reaching about 90% of the relative abundance. Biotransformation of cinnamyl alcohol using C. acutatum in a Sabouraud medium can offer a simple and efficient way to obtain 2-phenylethanol with high yield.

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“…Penz. & Sacc., de alta versatilidad y eficiencia en su capacidad para transformar, de manera regio-y/o estereoselectiva, terpenos, flavonoides y esteroides, entre otros (9). No obstante, muchas especies del género no han sido exploradas aún y se desconoce su potencialidad metabólica.…”

Section: Introductionunclassified

MICROBIAL TRANSFORMATION OF ARYLPROPANOID CINNAMALDEHYDE BY THE PHYTOPATHOGEN FUNGUS <I>Colletotrichum acutatum</I>

2009

Vitae

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Phytopathogenic fungi have the capacity to modify chemically a wide array of organic compounds turningthem into structurally related products. In this study, biotransformation of the substrate arylpropanoidtrans-cinnamaldehyde A achieved by the phylamentous phytopatogenic fungus Colletotrichum acutatum,is evaluated; the process is carried out in liquid media culture Czapeck-Dox. The biotransformationof the substrate A produces the metabolites cinnamyl alcohol B, 3-phenyl-1-propanol C, 3-phenyloxiranemethanolD and 1-phenyl-1,3-propanediol E. The structures of metabolic products are determinedby gas chromatography coupled with mass spectrometry (GC-MS) and nuclear magnetic resonance ofproton and carbon (1H and 13C NMR). The process is marked by the tendency of the pathogen to producehydroxylations on the substituent of the aromatic ring. Additionally, it has the capability to reduce thecarbonyl group and the double bond. In the process, several metabolic products used like raw materials for different industries are generated. A possible metabolic pathway of the biotransformation of transcinnamaldehydeby C. acutatum is also discussed.

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Biotransformations by Colletotrichum species

Cited by 57 publications

References 35 publications

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

PRODUCTION OF 2-PHENYLETHANOL IN THE BIOTRANSFORMATION OF CINNAMYL ALCOHOL BY THE PLANT PATHOGENIC FUNGUS <I>Colletotrichum acutatum</I>

MICROBIAL TRANSFORMATION OF ARYLPROPANOID CINNAMALDEHYDE BY THE PHYTOPATHOGEN FUNGUS <I>Colletotrichum acutatum</I>

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