Biotransformed bear bile powder ameliorates diet-induced nonalcoholic steatohepatitis in mice through modulating arginine biosynthesis via FXR/PXR-PI3K-AKT-NOS3 axis

Jiang, Shan; Wei, Xiaolu; Zhang, Yan; Wang, Linna; Wang, Lianmei; Wang, Mengxiao; Rong, Yan; Zhou, Junyi; Zhou, Yanyan; Wang, Hongjie; Li, Tao; Si, Nan; Bian, Baolin; Zhao, Haiyu

doi:10.1016/j.biopha.2023.115640

Cited by 9 publications

(1 citation statement)

References 49 publications

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“…Breakthrough progress has been achieved in the replacement of rhinoceros horns with water buffalo horns, replacement of tiger bone with dog bone, [21] and the research and development of artificially synthesized bear bile powder. [22,23] Preclinical research has been accomplished for artificially synthesized antelope horns, and artificial musk, [24] synthetic bovine bezoar, and artificial tiger bone [25] have been approved for clinical use. By 2021, China has approved the use of 8 kinds of artificial medicinal materials: artificial borneol, artificial musk, synthetic bovine bezoar, in vitro cultured bovine bezoar, synthetic bovine bezoar, artificial tiger bone, artificial Cordyceps sinensis , and artificial tabasheer.…”

Section: Successful Practices and Experience In Protecting Chinese Me...mentioning

confidence: 99%

Protection and sustainable utilization of traditional medicinal biogenetic resources

2024

Sci Tradit Chin Med

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Section: Successful Practices and Experience In Protecting Chinese Me...mentioning

confidence: 99%

Protection and sustainable utilization of traditional medicinal biogenetic resources

2024

Sci Tradit Chin Med

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Exploring the mechanisms of Cornus officinalis in the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking and molecular dynamics simulations

Guo,

Wan,

Wang

2024

Discov Appl Sci

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Non-alcoholic steatohepatitis (NASH) is a predominant metabolic liver disease, typically characterized by hepatic steatosis, oxidative stress, and inflammation. The traditional Chinese medicine Cornus officinalis possesses anti-inflammatory and hepatoprotective pharmacological properties and has shown ameliorative effects on NASH. however, its mechanism of action remains unclear. This study aims to elucidate the mechanisms by which C. officinalis ameliorates NASH. The active components of C. officinalis were analyzed using the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the corresponding targets were predicted. Subsequently, the DisGeNET, GeneCards, and GEO databases were employed to identify NASH-related targets. Venn diagrams were used to intersect the C. officinalis targets with the NASH targets. Protein–protein interaction (PPI) networks were constructed using the STRING database, and PPI network analysis was performed using Cytoscape. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID), followed by molecular docking validation. Cornus officinalis was found to contain 20 major active ingredients corresponding to 672 potential targets, 61 of which overlapped with NASH targets. PPI network, GO, and KEGG pathway analyses identified four targets with the highest correlation, and molecular docking results indicated that the active ingredients of C. officinalis exhibited strong binding affinities to NASH targets. The treatment of NASH with C. officinalis is characterized by multiple active ingredients and multiple targets, underscoring the major advantage of traditional Chinese medicine in treating NASH.

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Biotransformed bear bile powder alleviates diet-induced nonalcoholic fatty liver disease in mice by regulating the gut microbiota and reversing lipid metabolism

Jiang,

Wei,

Wang

et al. 2024

Arabian Journal of Chemistry

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Biotransformed bear bile powder ameliorates diet-induced nonalcoholic steatohepatitis in mice through modulating arginine biosynthesis via FXR/PXR-PI3K-AKT-NOS3 axis

Cited by 9 publications

References 49 publications

Protection and sustainable utilization of traditional medicinal biogenetic resources

Protection and sustainable utilization of traditional medicinal biogenetic resources

Exploring the mechanisms of Cornus officinalis in the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking and molecular dynamics simulations

Biotransformed bear bile powder alleviates diet-induced nonalcoholic fatty liver disease in mice by regulating the gut microbiota and reversing lipid metabolism

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