Biovariability of plasma adiponectin

Shand, Brett; Elder, Peter A.; Scott, Russell S.; Frampton, Christopher; Willis, Jinny

doi:10.1515/cclm.2006.227

Cited by 52 publications

(35 citation statements)

References 17 publications

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“…Finally, the blood samples of this study were collected under nonfasting conditions. Whereas, this fact appears to have only a negligible impact on the level of adiponectin (45), an association between triglyceride and adiponectin concentrations cannot be evaluated leading to an incomplete picture of the lipid-adiponectin relationship in our patients.…”

Section: Discussionmentioning

confidence: 75%

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Galler¹,

Gelbrich²,

Kratzsch³

et al. 2007

eur j endocrinol

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Objective: Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type 1 diabetes in a longitudinal manner and to study the impact of age, gender, body mass index (BMI) and metabolic control. Research design and methods: In this study, 88 children and adolescents with type 1 diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids. Healthy children (nZ259) were chosen as a control group. Results: Serum adiponectin levels were significantly higher in children with type 1 diabetes compared with healthy children (13.1 vs 9.1 mg/ml at baseline, P!0.001). Adiponectin concentrations inversely correlated with BMI S.D.s (P!0.001). No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Adiponectin concentrations decreased in males with type 1 diabetes during puberty (PZ0.03) while there was no significant change in females. In a subgroup of patients with new onset type 1 diabetes, adiponectin concentrations were not different from adiponectin levels in control subjects but increased during follow-up (PZ0.007). Stepwise multiple regression analysis showed that most important predictors of adiponectin levels in type 1 diabetes at the end of the study were adiponectin concentration at baseline (bZ0.574, P!0.001) and BMI S.D.s (bZK0.302, PZ0.001, r 2 Z0.56). Conclusions: Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children.European Journal of Endocrinology 157 481-489

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Section: Discussionmentioning

confidence: 75%

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Galler¹,

Gelbrich²,

Kratzsch³

et al. 2007

eur j endocrinol

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“…However, at the time of collection, the samples were ideally treated to limit any influence on stability of samples. The effect of frozen storage on adiponectin levels has to our best knowledge been investigated under a maximum of 30 months, with no discernible effect of mean plasma adiponectin levels being reported (40). We are not aware of any other studies with longer follow-up, but most peptide hormones have been shown to be fairly stable, some peptides even during long-term storage up to 25 years (41).…”

Section: Discussionmentioning

confidence: 99%

Adiponectin and cardiac geometry and function in elderly: results from two community-based cohort studies

Gustafsson

Lind

Zethelius

et al. 2010

European Journal of Endocrinology

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Objective: Several smaller studies have indicated that adiponectin might be associated with left ventricular (LV) mass and function, but community-based studies with adequate sample size and adjustment for potential confounders are lacking. Our objective was to investigate such associations in two large community-based studies of elderly. Design: Cross-sectional. Methods: We evaluated cross-sectional relations between serum adiponectin and echocardiographic measures of cardiac geometry and function (LV mass index, LV relative wall thickness, LV end-diastolic diameter, left atrial diameter, ejection fraction, LV isovolumic relaxation time, and E/A ratio) in 954 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), and in 427 71-year-old men from the Uppsala Longitudinal Study of Adult Men (ULSAM). Results: In models adjusted for age, sex, body mass index, systolic blood pressure, antihypertensive treatment, antidiabetic treatment, lipid-lowering medication, fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, creatinine, and smoking, adiponectin was inversely associated with ejection fraction in men (b, K1.62; 95% confidence interval (CI), K2.50, K0.75 in PIVUS; b, K1.35; 95% CI, K2.41, K0.29 in ULSAM), but not in women. After additional adjustment for N-terminal pro-brain natriuretic peptide (NT-proBNP), the association between adiponectin and ejection fraction was attenuated (b, K0.98; 95% CI, K1.86, K0.10 in PIVUS; b, K0.75; 95% CI, K1.84, 0.35 in ULSAM). Conclusions: Serum adiponectin concentrations were associated with ejection fraction in men, and these associations were partially attenuated by NT-proBNP. Our results imply that adiponectin may be associated with systolic function through pathways that involve natriuretic peptides.

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“…Although plasma adiponectin levels do not vary markedly over longer periods of time in the absence of significant body weight changes (20), there may be a short-term biovariability. Short-term biovariability has been found to be twofold greater in healthy subjects than in those with the metabolic syndrome (21), and the present study has focused on healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Dietary factors associated with plasma high molecular weight and total adiponectin levels in apparently healthy women

Yannakoulia¹,

Yiannakouris²,

Melistas³

et al. 2008

European Journal of Endocrinology

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Objective: Our aim was to investigate associations between dietary factors and high molecular weight (HMW) as well as total adiponectin in a sample of apparently healthy adult Mediterranean women. Design and methods: Two hundred and twenty women were enrolled in this study. Anthropometric and body composition measurements were performed in all subjects. Fasting blood samples were taken; HMW and total adiponectin concentrations were measured. Food intake was evaluated using 3-day food records. The frequency of consumption of several food groups was approximately quantified in terms of number of servings per day. Furthermore, dietary intakes of betaine, choline, and free choline were estimated. Results: Women in the highest HMW adiponectin tertile had higher fruit intake compared with those with lower levels, after adjusting for potential confounders (PZ0.04). On the contrary, dietary betaine and choline intakes were not different among HMW adiponectin tertiles. In linear models, fruit consumption, controlling for biological and lifestyle variables, was significantly related to HMW adiponectin (partial rZ0.15, PZ0.04), but the association with total adiponectin did not reach statistical significance (partial rZ0.11, PZ0.12). A significant negative correlation between total adiponectin and refined cereals was also observed (partial rZK0.16, PZ0.03). Discussion: This is the first study that evaluates associations between dietary factors and HMW adiponectin levels. The associations found are moderate and indicate that, after multivariate adjustment, fruit consumption is related to HMW adiponectin in both linear and nonlinear models.European Journal of Endocrinology 159 R5-R10

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Biovariability of plasma adiponectin

Abstract: These results demonstrate that plasma adiponectin levels have relatively low biovariability and that adiponectin can be sampled fasting or non-fasting to provide a reliable marker of insulin resistance and incipient type 2 diabetes.

Cited by 52 publications

References 17 publications

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Adiponectin and cardiac geometry and function in elderly: results from two community-based cohort studies

Dietary factors associated with plasma high molecular weight and total adiponectin levels in apparently healthy women

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