Bipedal hopping timed to a metronome to detect impairments in anticipatory motor control in people with mild multiple sclerosis

Kirkland, Megan C.; Chen, Alice; Downer, Matthew B.; Holloway, Brett J.; Wallack, Elizabeth M.; Lockyer, Evan J.; Buckle, Natasha C.M.; Abbott, Courtney; Ploughman, Michelle

doi:10.1016/j.clinbiomech.2018.04.009

Cited by 7 publications

(5 citation statements)

References 187 publications

(352 reference statements)

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“…All other studies that investigated jumping in MS examined bipedal jumps. 21,23,24 Our study is the first to characterise single-leg jumps in MS.Our results suggest that pwMS-NM have significantly reduced SLCMJ performance compared to HC with the highest effect sizes for negative power and jump height. These results are consistent with Stagsted et al who showed that pwMS often Abbreviations: pwMS, people with Multiple Sclerosis, pwMS-RM, people with multiple sclerosis with reduce muscle strength, pwMS-NM, people with multiple sclerosis with normal muscle strength, HC, healthy controls, ND, non-dominant leg, D, dominant leg, LSI, Limb-Symmetry-Index, FZV, Force at Zero Velocity, FTCTR, Flight-Time-Contraction-Time Ratio.…”

Section: Discussionmentioning

confidence: 70%

“…19,21,22 Two pilot studies of Kirkland et al provide initial evidence that jumping, as a complex and innovative novel assessment tool in MS, can reveal differences between pwMS with mild disability and HCs, and is potentially useful for assessing lower limb neuromuscular function in pwMS. 21,23 In our previous pivotal study, we found that pwMS without any strength, coordination, and sensory impairments of the legs required more complex assessments, such as the countermovement jump (CMJ), a bipedal vertical jump, to identify neuromuscular deficits below the clinical threshold of EDSS. 24 The pwMS with full motor function showed significantly reduced CMJ performance in almost all observed kinetic, temporal, and performance parameters compared to the HC in this study.…”

Section: Introductionmentioning

confidence: 99%

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Sensitive Identification of Asymmetries and Neuromuscular Deficits in Lower Limb Function in Early Multiple Sclerosis

Geßner,

Hartmann,

Vágó

et al. 2024

Neurorehabil Neural Repair

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Background In the early stages of multiple sclerosis (MS), there are no objective sensitive functional assessments to identify and quantify early subclinical neuromuscular deficits and lower limb strength asymmetries during complex movements. Single-countermovement jumps (SLCMJ), a maximum single leg vertical jump, on a force plate allow functional evaluation of unilateral lower limb performance in performance diagnostics and could therefore provide early results on asymmetries in MS. Objective Objective evaluation of early lower limb neuromuscular deficits and asymmetries in people with multiple sclerosis (pwMS) using SLCMJ on a force plate. Methods A study was conducted with pwMS (N = 126) and healthy controls (N = 97). All participants performed 3 maximal SLCMJs on a force plate. Temporal, kinetic, and power jump parameters were collected. The Expanded Disability Status Scale (EDSS) was performed on all participants. A repeated measures analysis of covariance (ANCOVA) with age, Body-Mass-Index, and gender as covariates was used. Results PwMS with normal muscle strength according to the manual muscle tests showed significantly reduced SLCMJ performance compared to HC. In both groups, jumping performance differed significantly between the dominant and non-dominant leg, with higher effect size for pwMS. A significant interaction effect between leg dominance and group was found for propulsive time, where the pwMS showed an even higher difference between the dominant and non-dominant leg compared to HC. Furthermore, there was a significant small correlation between leg asymmetries and EDSS in pwMS. Conclusion The study shows that the SLCMJ on a force plate is suitable for the early detection of subclinical lower limb neuromuscular deficits and strength asymmetries in MS.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Sensitive Identification of Asymmetries and Neuromuscular Deficits in Lower Limb Function in Early Multiple Sclerosis

Geßner,

Hartmann,

Vágó

et al. 2024

Neurorehabil Neural Repair

View full text Add to dashboard Cite

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“…This difference may be relevant as a change of 15% could be significant [48] and the fact that the control group walked at a high-intensity level controlled by rating perceived exertion. Nonetheless, the intervention group introduced this intensity by metabolic stress with the BFR intervention, and controlled the rests with a metronome, which may have produced better results at the brain level, especially anticipatory motor control [49]. In self-selected walking velocity (SSWV), both groups improved between 0.46 and 0.49 m per second, which may indicate that subjects with knee arthroscopy obtain the same benefits from BFR intervention and mechanical stimulus of the loads [43].…”

Section: Speedmentioning

confidence: 99%

Effectiveness of Blood Flow Restriction on Functionality, Quality of Life and Pain in Patients with Neuromusculoskeletal Pathologies: A Systematic Review

Reina-Ruiz

Martínez-Cal

Molina-Torres

et al. 2023

IJERPH

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Background: Blood flow restriction is characterized as a method used during exercise at low loads of around 20–40% of a repetition maximum, or at a low-moderate intensity of aerobic exercise, in which cuffs that occlude the proximal part of the extremities can partially reduce arterial flow and fully restrict the venous flow of the musculature in order to achieve the same benefits as high-load exercise. Objective: The main objective of this systematic literature review was to analyze the effects of BFR intervention on pain, functionality, and quality of life in subjects with neuromusculoskeletal pathologies. Methods: The search to carry out was performed in PubMed, Cochrane, EMBASE, PEDro, CINHAL, SPORTDiscus, Trip Medical Database, and Scopus: “kaatsu” OR “ischemic training” OR “blood flow restriction” OR “occlusion resistance training” OR “vascular occlusion” OR “vascular restriction”. Results: After identifying 486 papers and eliminating 175 of them due to duplication and 261 after reading the title and abstract, 50 papers were selected. Of all the selected articles, 28 were excluded for not presenting a score equal to or higher than 6 points on the PEDro scale and 8 for not analyzing the target outcome variables. Finally, 14 papers were selected for this systematic review. Conclusions: The data collected indicate that the blood flow restriction tool is a therapeutic alternative due to its effectiveness under different exercise modalities. The benefits found include decreases in pain thresholds and improvement in the functionality and quality of life of the neuro-musculoskeletal patient during the first six weeks. However, the results provided by this tool are still not clear for medium- and long-term interventions.

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“…To our knowledge, there are no studies that investigate CMJ performance in MS. Two pilot studies from Kirkland et al [ 21 , 22 ] provide the first evidence that jump tasks can detect differences between pwMS with mild disability and healthy controls and that they are a potentially useful measurement of lower limb function in pwMS. However, in contrast to our study, Kirkland et al assessed the use of horizontal jumps on an instrumental walkway system with small sample size.…”

Section: Introductionmentioning

confidence: 99%

Countermovement Jumps Detect Subtle Motor Deficits in People with Multiple Sclerosis below the Clinical Threshold

et al. 2023

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In the early stages of multiple sclerosis (MS), there are currently no sensitive assessments to evaluate complex motor functions. The countermovement jump (CMJ), a high-challenge task in form of a maximal vertical bipedal jump, has already been investigated as a reliable assessment in healthy subjects for lower extremity motor function. The aim was to investigate whether it is possible to use CMJ to identify subthreshold motor deficits in people with multiple sclerosis (pwMS). All participants (99 pwMS and 33 healthy controls) performed three maximal CMJs on a force plate. PwMS with full motor function and healthy controls (HC) did not differ significantly in age, disease duration, Body Mass Index and the Expanded Disability Scale Score. In comparison to HC, pwMS with full motor function demonstrated a significantly decreased CMJ performance in almost all observed kinetic, temporal and performance parameters (p < 0.05). With increasing disability in pwMS, it was also observed that jump performance decreased significantly. This study showed that the CMJ, as a high challenge task, could detect motor deficits in pwMS below the clinical threshold of careful neurological examination. Longitudinal studies are pending to evaluate whether the CMJ can be used as a standardized measure of disease progression.

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Bipedal hopping timed to a metronome to detect impairments in anticipatory motor control in people with mild multiple sclerosis

Cited by 7 publications

References 187 publications

Sensitive Identification of Asymmetries and Neuromuscular Deficits in Lower Limb Function in Early Multiple Sclerosis

Sensitive Identification of Asymmetries and Neuromuscular Deficits in Lower Limb Function in Early Multiple Sclerosis

Effectiveness of Blood Flow Restriction on Functionality, Quality of Life and Pain in Patients with Neuromusculoskeletal Pathologies: A Systematic Review

Countermovement Jumps Detect Subtle Motor Deficits in People with Multiple Sclerosis below the Clinical Threshold

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