Biphasic cardiovascular and respiratory effects induced by β-citronellol

Abstract

β-Citronellol is a monoterpene found in the essential oil of various plants with antihypertensive properties. In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespiratory effects. In anesthetized rats, intravenous injection of β-citronellol caused biphasic hypotension, bradycardia and apnea. Bilateral vagotomy, perivagal capsaicin treatment or injection into the left ventricle abolished first rapid phase (named P1) but not delayed phase P2 of the β-citronellol effects. P1 persisted after pretreatment with capsazepine, ondansetron, HC-030031 or suramin. Suramin abolished P2 of apnea. In awake rats, β-citronellol induced biphasic hypotension and bradycardia being P1 abolished by methylatropine. In vitro, β-citronellol inhibited spontaneous or electrically-evoked contractions of rat isolated right or left atrium, respectively, and fully relaxed sustained contractions of phenylephrine in mesenteric artery rings. In conclusion, chemosensitive pulmonary vagal afferent fibers appear to mediate the cardiovascular and respiratory effects of β-citronellol. The transduction mechanism in P1 seems not to involve the activation of transient receptor potential vanilloid subtype 1 (TRPV1), transient receptor potential ankyrin subtype 1 (TRPA1), purinergic (P2X) or 5-HT3 receptors located on airways sensory nerves. P2 of hypotension and bradycardia seems resulting from a cardioinhibitory and vasodilatory effect of β-citronellol and the apnea from a purinergic signaling.

Cardiovascular Effects of Trans-4-Methoxy-β-Nitrostyrene in Spontaneously Hypertensive Rats: Comparison With Its Parent Drug β-Nitrostyrene

“…), respectively (data not shown). Similar findings were previously reported in studies performed in normotensive rats (de Siqueira et al, 2006; de Siqueira et al, 2010; Ribeiro-Filho et al, 2016).…”

α-Terpineol Induces Gastric Retention of Liquids by Inhibiting Vagal Parasympathetic Pathways in Rats

“…It was suggested that compounds with different chemical structures could inhibit nerve conduction possibly without TRP activation. In this direction, functional tests performed in the presence of TRPV1 or TRPA1 antagonists failed to demonstrate a role for TRPs in the pharmacological effects of linalool [20] or β-citronellol [21,22], two volatile compounds possessing the ability to activate TRPs [19,23]. Thus, the chances to obtain a positive result in experiments that combine α-terpineol and antagonists of TRPs under our experimental conditions appear small.…”

Artificial turf: chemical flux and development of silicone wristband partitioning coefficients

“…Several personal care products were detected using the 1530 screen in both air and turf air samplers. The chemical b-citronellol is a component of perfumes and essential oils of various plants (Ribeiro-Filho et al 2016). Benzyl salicylate, a scent compound (Lapczynski et al 2007) was present in all air samples, but absent in all turf air samples.…”