2011
DOI: 10.1007/s00213-011-2301-9
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Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat

Abstract: Escalation of MA intake produces both transient and long-lasting effects upon DA, TH, and DAT in the mesoaccumbens pathway. The eventual decrease of DA in the VTA is speculated to contribute to craving for MA and, thus, may be associated with MA escalation and resulting dopaminergic toxicity.

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Cited by 26 publications
(51 citation statements)
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References 68 publications
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“…19 DAT expression is much less in SN and VTA compared with striatum and nucleus accumbens in rodent, 19 and the present results provide additional evidence that DA regulation is less influenced by DAT in the somatodendritic compartments. The loss of DAT was associated with decreased DA tissue content and TH protein, but only in the terminal fields of striatum and nucleus accumbens.…”
Section: Discussionsupporting
confidence: 51%
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“…19 DAT expression is much less in SN and VTA compared with striatum and nucleus accumbens in rodent, 19 and the present results provide additional evidence that DA regulation is less influenced by DAT in the somatodendritic compartments. The loss of DAT was associated with decreased DA tissue content and TH protein, but only in the terminal fields of striatum and nucleus accumbens.…”
Section: Discussionsupporting
confidence: 51%
“…Dopamine release in the substantia nigra has been established for 40 years, 38,39 and this study further supports that TH function may be a primary component of how much DA is available for release, particularly since evidence also shows that DA D 2 agonists are much less effective in inhibiting DA release therein 40 and shows less efficiency of DA uptake in the midbrain 1–3,41 and less DA release in the midbrain. 24,42 The expression of DAT protein relative to TH protein is nearly 10–20-fold less in the somatodendritic compartments versus the terminal fields, 19 and DA tissue content is more dependent upon TH function in the somatodendritic regions. 5 Our results seem to further extend the critical differences in DA regulation between the two compartments, which may come into play to determine how DAT affects TH activity in DA-dependent behavioral outcomes, 4347 particularly if considering the influence of DA neurotransmission in the somatodendritic compartments upon behavior 2528,4850 and in disease states affected by DA loss like Parkinson’s disease.…”
Section: Discussionmentioning
confidence: 99%
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“…On PND 21 weaned male rat pups were divided into SIR and group-reared rats. Rats were injected twice daily and subcutaneously with either saline or an escalating dose of MA, starting with 0.2 mg/kg on PND 35 and ending with 6 mg/kg on PND 50 (table 1) [27,28,29]. Dosing with MA or saline took place at 9.00 and 15.00 h every day for 16 consecutive days.…”
Section: Methodsmentioning
confidence: 99%