2019
DOI: 10.1111/jcmm.14672
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Biphasic effects of autophagy on decompression bubble‐induced endothelial injury

Abstract: Endothelial dysfunction induced by bubbles plays an important role in decompression sickness (DCS), but the mechanism of which has not been clear. The present study was to investigate the role of autophagy in bubble‐induced endothelial injury. Human umbilical vein endothelial cells (HUVECs) were treated with bubbles, autophagy markers and endothelial injury indices were determined, and relationship strengths were quantified. Effects of autophagy inhibitor 3‐methyladenine (3‐MA) were observed. Bubble contact fo… Show more

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Cited by 3 publications
(3 citation statements)
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“…Based on the autochthonous bubbles hypothesis, the influence of microbubbles has also displayed on endothelial cells and neurons. For instance, intravascular bubbles stimulation on endothelial cells has been confirmed the autophagy on vascular inflammation cascades and detrimental effects of endothelium injury 33,34 . Furthermore, serum injury biomarkers induced by decompression bubbles were reflection on oxidative stress and inflammatory responses in spinal cord 35 .…”
Section: Discussionmentioning
confidence: 88%
See 1 more Smart Citation
“…Based on the autochthonous bubbles hypothesis, the influence of microbubbles has also displayed on endothelial cells and neurons. For instance, intravascular bubbles stimulation on endothelial cells has been confirmed the autophagy on vascular inflammation cascades and detrimental effects of endothelium injury 33,34 . Furthermore, serum injury biomarkers induced by decompression bubbles were reflection on oxidative stress and inflammatory responses in spinal cord 35 .…”
Section: Discussionmentioning
confidence: 88%
“…For instance, intravascular bubbles stimulation on endothelial cells has been confirmed the autophagy on vascular inflammation cascades and detrimental effects of endothelium injury. 33,34 Furthermore, serum injury biomarkers induced by decompression bubbles were reflection on oxidative stress and inflammatory responses in spinal cord. 35 Microparticles formation triggered from the vasculature by bubbles was also the main cause of vascular injury or spinal decompression illness.…”
Section: So How Did Microbubbles Stimulation Lead To Bmmcs Activation?mentioning
confidence: 99%
“…The vascular endothelium has a critical role in mediating vasoreactivity through autocrine and paracrine functions that can mediate vasoconstriction and vasodilation. There is evidence from multiple studies that bubble interactions with endothelium may damage endothelium [20][21][22] and impair these functions. 6,7,23 Some of these studies arise in the context of diving where the intravascular inert gas bubbles formed during decompression are similar in size 24 to those recorded in the cerebral vessels during cardiac surgery.…”
Section: Discussionmentioning
confidence: 99%