Biphasic pulmonary blastoma associated with cerebral metastasis

Kılıç, Dalokay; Yilmaz, Cem; Tepeoğlu, Merıh; Vural, Çiğdem; Caner, Hakan

doi:10.5137/1019-5149.jtn.10520-14.2

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…The hypoglycemia can be controlled through chemotherapy, radiotherapy, and embolization with various success rates [ 9 ]. PBs are fast growing tumors with poor prognosis [ 4 , 6 ]. Factors that illustrate the poor prognosis in adult PBs include relapse, metastatic illness, larger than 5 cm tumor, and lymphatic system involvement [ 6 , 7 , 13 ].…”

Section: Case Presentationmentioning

confidence: 99%

Pulmonary blastoma: a case report and brief review of the literature of tumor-induced hypoglycemia

Tehrani

Abdehgah

Molavi

et al. 2015

J Diabetes Metab Disord

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BackgroundTumor induced hypoglycemia (TIH) is a rare clinical entity that can be caused by different mechanisms such as secretion of various substances, autoimmune disorders, massive tumoral infiltration of liver, and pituitary or adrenal glands destruction by tumors. Furthermore, any type of neoplasms can cause TIH.Case presentationThe patient presented with a case of classic biphasic pulmonary blastoma (CBPB) with hypoglycemia. Chest CT scan showed 2 huge masses in the right hemi-thorax and multiple smaller masses located in the left hemi-thorax. The patient underwent surgery, and was referred to an oncologist for adjuvant therapy.ConclusionCBPB is a rare primary lung tumor with poor prognosis. They are classically large, symptomatic tumors with lymph node metastasis. Surgical resection at early stages has been more effective than other treatments; however, there is no standard treatment in unresectable cases. Adjuvant treatments have been temporarily effective.

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Section: Case Presentationmentioning

confidence: 99%

Pulmonary blastoma: a case report and brief review of the literature of tumor-induced hypoglycemia

Tehrani

Abdehgah

Molavi

et al. 2015

J Diabetes Metab Disord

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“…However, cerebral metastasis from pulmonary blastoma is extremely rare. Since the first description of cerebral metastasis from pulmonary blastoma in 1968 by Barson et al [ 4 ], metastatic brain tumor has been reported in only 13 cases of pulmonary blastoma, including this case ( Table 1 ) [ 4 5 6 7 8 9 10 11 12 13 14 15 ]. Owing to its rarity, there are no studies on metastatic brain tumor from pulmonary blastoma regarding the tendency of multiple or solitary metastasis, propensity of bleeding, and treatment strategy.…”

Section: Discussionmentioning

confidence: 95%

“…Before 2015, only 11 cases of metastatic brain tumor from pulmonary blastoma were reported [ 5 ]. Based on the literature, to date, a total of 13 cases have been reported, including our case [ 4 5 6 7 8 9 10 11 12 13 14 15 ].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Metastatic Brain Tumor From Classic Biphasic Pulmonary Blastoma Presented as Intracerebral Hemorrhage

Park

Byun

Song

et al. 2021

Brain Tumor Res Treat

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Pulmonary blastoma is a rare type of primary lung cancer that accounts for only 0.25%–0.5% of all lung malignancies. Pulmonary blastoma consists of three subgroups: classic biphasic pulmonary blastoma (CBPB), pleuropulmonary blastoma, and well-differentiated fetal adenocarcinoma. Due to the rarity of the tumor, metastatic brain tumor from CBPB is extremely rare, and only 13 cases, including our case, have been reported. A 60-year-old woman who underwent left upper lobectomy of the lung because of pathologically diagnosed as CBPB 5 months ago, suddenly lost consciousness and presented with stupor mental status. The emergent CT scan showed a large, 51 mL, intracerebral hemorrhage on left parieto-occipital lobe with midline shifting. The patient underwent emergent craniotomy, and a hypervascular tumor was identified during the operation. Histopathologic examination reported metastatic pulmonary blastoma, CBPB. The patient has been in a vegetative state, but there has been no evidence of recurrence over a 6-month follow-up period. We report a rare case of brain metastasis from CBPB presenting with altered mentality due to massive tumor bleeding. This is the only reported case of brain metastasis from CBPB presenting with acute intracerebral hemorrhage.

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“…Prognosis is poor with two thirds of patients dying within 2 years after diagnosis and is determined by recurrence, gross size of the tumor (>5 cm) and presence of metastasis at diagnosis (3). It has a high incidence of recurrence (43%) within the first year after treatment and a propensity for metastasizing to the mediastinum, pleura, diaphragm, liver, heart and soft tissues and brain (2,7,17,18).…”

Section: Discussionmentioning

confidence: 99%

Classic biphasic pulmonary blastoma: importance of early treatment—a case report

Carrasco¹,

Blanco²,

Otero³

et al. 2021

Curr Chall Thorac Surg

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Classic biphasic pulmonary blastoma is a very aggressive malignant tumor with very poor prognosis and its overall mortality is very high. It belongs to sarcomatoid neoplasms subgroup in the WHO classification of lung tumors. In the histological analysis shows an immature epithelial and mesenchymal stroma. It is more frequent in middle-age men and can be related with tobacco. Surgery with complete resection is the mainstay of treatment. The role of the chemotherapy or radiotherapy is not very clear because of the rarity and low frequency of this neoplasm. We describe the case of a 63-year-old man that consulted for 2 days history of chest pain and fever. He was diagnosed of a mass of 12 cm [standardized uptake value (SUV) 6.2 g/mL] in the right hemithorax that was complicated with intratumoral bleeding requiring an emergency surgery because of sudden dyspnea, anemia, hypotension and mediastinal shift.Through a median sternotomy and right anterior thoracotomy a right pneumonectomy was performed.Final classification was pT4N1PL2. The patient received adjuvant chemoradiotherapy that was well tolerated. Overall survival was very good (33 months) because of the multimodal treatment. He presented a recurrence manifested by a mass invading the right ventricle in the 28-month post-surgery. After three cycles of chemotherapy he died because of progression of the disease 5 months later. With this case report we want to share our experience in the treatment of this infrequent pathology that must be urgently addressed when intratumoral bleeding occurs.

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Biphasic pulmonary blastoma associated with cerebral metastasis

Cited by 7 publications

References 21 publications

Pulmonary blastoma: a case report and brief review of the literature of tumor-induced hypoglycemia

Pulmonary blastoma: a case report and brief review of the literature of tumor-induced hypoglycemia

A Rare Case of Metastatic Brain Tumor From Classic Biphasic Pulmonary Blastoma Presented as Intracerebral Hemorrhage

Classic biphasic pulmonary blastoma: importance of early treatment—a case report

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