Biphasic synovial sarcomas of the liver: a case report and literature review

Abstract

Background Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been reported in the domestic and international literature. Case presentation We report an 11-year-old female patient who underwent partial hepatectomy for a liver mass. Microscopically, she was diagnosed with hepatic biphasic synovial sarcoma. Cytogenetic examination revealed the fusion gene SS18-SSX1 (+), which confirmed the diagnosis. Conclusion Synovial sarcoma of the liver is a rare malignancy that is difficult to diagnose. Confirmation of diagnosis is based on histopathological assessment combined with immunohistochemical staining and, if necessary, cytogenetic aids.

Biphasic synovial sarcoma with squamous differentiation in the thigh – A case report

“…Whereas myogenin, CK20, PAX-8, WT-1, SMA, S-100, CD34 and desmin were negative. 5 In support with the above studies the IHC analysis in our case also showed that SMA, CD 99, Vimentin, Bcl-2 and CD 68 were positive in spindle cell component. Pan CK and p63 showed nuclear expression in epithelial component.…”

“…The studies concluded that it is an important basis for the diagnosis of synovial sarcoma. 5 However, we could not do the molecular study since the patient was not affordable.…”