Bipolar Disorder in Adult Patients with Tourette’s Syndrome: A Clinical Study

Berthier, Marcelo L.; Kulisevsky, Jaime; Campos, Victor

doi:10.1016/s0006-3223(97)00025-5

Cited by 39 publications

(28 citation statements)

References 37 publications

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“…Several personality disorders are found in TS, at a higher prevalence than in the general population, 14,39,52 which may be explained by several factors. The obsessive-compulsive personality is a risk factor for the development of OCD, one of the most prevalent psychiatric disorders in patients with TS.…”

Section: Personality Disordersmentioning

confidence: 98%

“…12 Berthier et al 52 identified a dysfunction of the relation between the extrapyramidal and the limbic systems. In fact, manic episodes are observed in other pathologies that involve subcortical structures, such as Huntington's disease.…”

Section: Ocd and Other Anxiety Disordersmentioning

confidence: 99%

“…Berthier et al 52 found that bipolar disorder in patients with TS is associated with other comorbidities, such as OCD, generalized anxiety disorder, eating disorders, panic disorder, social phobia and ADHD. Interestingly, in their study, all patients had a personality disorder.…”

Section: Mood Disordersmentioning

confidence: 99%

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Tourette's syndrome and associated disorders: a systematic review

Ferreira

Pio-Abreu

Januário

2014

Trends Psychiatry Psychother.

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Objective: To compile data on Tourette's syndrome (TS), tics and associated disorders. Methods: A systematic review of the literature was conducted using the 5S levels of organization of healthcare research evidence (systems, summaries, synopses, syntheses, studies), based on the model described by Haynes. The search keywords were Tourette, tics and comorbidity, which were cross-referenced. Studies provided by publishers and articles being processed on July 31, 2013, were also included. Results: Of all studies retrieved during the search, 64 were selected because they analyzed the epidemiology, clinical features and etiopathogenesis of TS and its comorbidities. TS is classified as a hyperkinetic movement disorder, and at least 90% of the patients have neuropsychiatric comorbidities, of which attention deficit hyperactivity and obsessive-compulsive disorders are the most common. The syndrome is clinically heterogeneous and has been associated with a dysfunction of cortico-striatal-thalamic-cortical circuits involving various neurotransmitters. Although its genetic etiology has been widely studied, other factors may be important to understand this syndrome and its associated disorders. Conclusions: TS is a neurodevelopmental disorder that results from the impact of stress factors on a vulnerable biological substrate during the critical periods of neurodevelopment. The study of TS and its comorbidities may contribute, at different levels, to the understanding of several neuropsychiatric disorders of clinical and therapeutic relevance. Keywords: Attention deficit disorder with hyperactivity, comorbidity, obsessive-compulsive disorder, tics, Tourette's syndrome. ResumoObjetivo: Compilar o conhecimento existente sobre a síndrome de Tourette (ST), tiques e patologias associadas. Metodologia: Foi realizada uma revisão sistemática da literatura usando os níveis 5S (sistemas, sumários, sinopses, sínteses e estudos) de organização de evidência de pesquisa em saúde, com base no modelo proposto por Haynes. Os termos de busca foram Tourette, tiques e comorbidades, completados por pesquisa por referência cruzada. Os artigos fornecidos pelos editores e aqueles a serem processados para publicação em 31 de julho de 2013 também foram incluídos. Resultados: De todos os artigos encontrados durante a pesquisa, 64 foram selecionados porque analisavam a epidemiologia, as características clínicas e a etiopatogenia da ST. A ST define-se como um distúrbio hipercinético do movimento, e pelo menos 90% dos pacientes apresentam comorbidades neuropsiquiátricas, das quais as mais comuns são a perturbação de déficit de atenção com hiperatividade e a perturbação obsessivo--compulsiva. Esta síndrome é clinicamente heterogênea e tem sido relacionada com a disfunção dos circuitos córtico-estriado--tálamo-corticais envolvendo vários neurotransmissores. Apesar de sua etiologia genética ter sido amplamente estudada, outros fatores podem ser importantes para entender esta síndrome e as perturbações relacionadas. Conclusões: A ST resulta de uma p...

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Section: Personality Disordersmentioning

confidence: 98%

Section: Ocd and Other Anxiety Disordersmentioning

confidence: 99%

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Tourette's syndrome and associated disorders: a systematic review

Ferreira

Pio-Abreu

Januário

2014

Trends Psychiatry Psychother.

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“…The Yale Global Tic Severity Scale (YGTSS) 16 was used to rate the type and severity of tics, and other psychiatric diagnoses were established with standardized rating scales based on DSM-IV criteria. 13 Completed suicide was defined as a fatal self-inflicted destructive act with explicit or inferred intent to die. 1 Attempted suicide was diagnosed when the individual had undertaken the intended act.…”

Section: Case Seriesmentioning

confidence: 99%

“…1 Although Tourette's syndrome (TS) is a frequent developmental tic disorder (1% of the population), 2 descriptions of suicide in this population are scant. [3][4][5][6][7][8][9][10] This is intriguing, because neuropsychiatric disorders occur in around 90% of TS patients attending specialized clinics, 11 and approximately one third of them show depression, 3,12 bipolar disorder, 3,13 or impulsive self-injurious behavior 14 that may predispose to suicidal behavior. Here, we report a case series of TS patients who completed suicide or attempted suicide and a literature review.…”

mentioning

confidence: 99%