S econdary mania (SM) is a syndrome defined as "manic symptoms that occur secondary to medical and/or pharmacologic antecedents".' Medications metabolic disturbances, space-occupying lesions, epilepsy, multiple sclerosis, head trauma," central nervous system infections, and systemic disorders" may predispose to the occurrence of SM.Manic states, like depressive syndromes, can occur throughout the life span." In comparison with depression, SM is less commons in the elderly medically ill population. Relatively late age at onset (over 40 years) is more common in SM as opposed to mania in bipolar (manic depression) patients (average around 25 years) (1). The~revalence of mania, in general, is low in the elderly." Patients who develop mania for the first time in late life mayor may not have had prior depressive episodes, and they mayor may not have a family history of bipolar illness."We present three cases of SM in late life. The patients described had total remission of their manic symptoms after the precipitating factors were identified and eliminated.
CASE REPORTSPatient 1 An 85-year-old white man began 2 months ago to overspend his money. One day he gave $600 dollars to a stranger, spent most of his savings, and bought a new truck.He slept a maximum of 2 hours a night; he felt energetic and became hyperactive and hypertalkative. He used obscene language, which he had never used before. His wife described him as if his personality had undergone a complete transformation. The patient insisted on setting the thermostat at a very high temperature, then left his house and walked in the freezing temperature without a coat. The neighbors had witnessed him digging holes under the house foundation. The patient never abused alcohol or drugs and was hospitalized 50 years ago and treated with electroconvulsive therapy for a psychotic episode characterized by auditory hallucinations (he heard the voice of a godfather talking to him) and bizarre religious preoccupations. Since then he had not had any psychiatric problems and was not taking any medications. His wife thought he had syphilis around the age of 20, which was treated with mineral baths. The patient was admitted to the psychiatric unit because of the manic symptoms, onset of decreased sleep, hyperactivity, overspending, and unusual behavior. Medical evaluation revealed normal physical and neurological examinations without focal signs. Work-up consisting of chemistry profile, complete blood count, urinalysis, electrolytes, fasting glucose, liver function tests, electroencephalogram, computed tomography, and magnetic resonance imaging of the head all yielded no abnormal findings. Urine and blood screens were negative for alcohol, medications, and drugs. The 24-hour urine collection for heavy metals, lead, arsenic, mercury, and cadmium was negative. Serological testing showed a non-reactive venereal disease research laboratory, a positive rapid plasma-reagin at 32 dilutions, and a positive serum fluorescent treponemal antibody absorption (FTA-ABS). Lumbar puncture and c...