Bipolar Polyethylene Radial Head Artroplasty in Posttraumatic Unstable Elbows Prosthetic design and clinical results

Sîrbu, Paul Dan; Tudor, Razvan; Berea, Grigore; Scripcaru, Andrei; Ciubara, Bogdan; Bădulescu, Oana Viola

doi:10.37358/mp.17.2.4837

Cited by 10 publications

(11 citation statements)

References 16 publications

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“…Osteoporosis is a major public health problem. Its main clinical manifestation and complication are fragility fractures that increase morbidity and mortality [1, 2, 16,17]. The healing process of fragility fractures is determined by age and bone quality.…”

Section: Resultsmentioning

confidence: 99%

Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?

Sîrbu¹,

Tudor²,

Veringa³

et al. 2017

Rev. Chim.

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Osteoporosis is a systemic skeletal disease characterized by low bone strength, which leads to an increased risk of fracture. The primary objective of osteoporosis treatment is the prevention of fragility fractures and the secondary objective is their rapid healing if they occur. Strontium ranelate is an antiosteoporotic therapeutic agent with a double action mechanism: the increase of bone formation and the decrease of bone resorption, contributing thus to the improvement of bone healing. Preclinical studies have demonstrated the efficacy of strontium ranelate for the improvement of bone healing and bone microarhitecture, as well as of the osteointegration of implants. Some clinical cases have been reported regarding the efficacy of strontium ranelate in the healing of long bone fractures complicated by nonunion or delayed union. In the present study we have reported 2 clinical cases that demonstrate the effectiveness of the treatment with strontium ranelate (Osseor) for 3-6 months in the healing of complicated long bone fractures with delayed union. Our cases confirm the results of the open label study CL3-12911-036 (delayed union and non-union fracture study), where the treatment with 2 g/day of strontium ranelate improved healing and led to a better quality of life. Even if there are some cardiovascular contraindications, strontium ranelate is proven to reduce vertebral and non-vertebral fracture risk in osteoporosis and in the same time improves bone microarchitecture and accelerates fracture healing.

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Section: Resultsmentioning

confidence: 99%

Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?

Sîrbu¹,

Tudor²,

Veringa³

et al. 2017

Rev. Chim.

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“…Therefore, there is still a great demand for new materials capable of improving the fixation strength especially for the osteoporotic bone. Currently, many synthetic materials, such as polymers, are in medical use: polyethylene, polyacrylate, polyurethanes (PU) [6]. Among all, we focus on polyurethane due to its high versatility that allows the simulation of human bone structure.…”

Section: Abstract: Polyurethane Acrylate Osteoporotic Fixation Fragmentioning

confidence: 99%

Preliminary Investigation on Mechanical Properties of Polymer Coating Screws for the Future Fragility Fracture Fixation

Filip¹,

Bădulescu²,

Sîrbu³

et al. 2019

Mat.Plast.

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Bone fracture fixation uses both consecrated materials, such as metals/metal alloys, as well as synthetic materials. Synthetic materials are extremely versatile in terms of simulating biological structures, biocompatibility and, in some cases, avoid the subsequent interventions for removing the prosthetic material. Fixing an osteoporotic fracture presents major risks of failure due mainly to the bone fragility. To reduce the risk of failure, prosthetic materials have been improved with various cements. The purpose of the current study was to assess the mechanical properties of different orthopedic screws covered with a new polyurethane acrylate polymer (PUA) in order to improve the stability of the screw for the subsequent fixation of the fragility fracture. To test the efficiency of the new polymer, the breaking/fracture strength of the orthopedic screws coated with PUA was evaluated, in comparison with the screws without coating material. Our data shows that tested PUA improves the bond between the screw and bone. We estimate that the effect obtained is caused by the partial damping of the loading force due to the elastic component of the polymer.

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“…Unlike primary hemostasis disorders such as thrombopathies, thrombocytopenia, or von Willebrand factor (VWF) deficiency, characterized by skin and mucosa bleeding, hemophilic patients experience deep bleeding that primarily affects the muscles and large joints. In severe hemophilia, 90% of the bleeding episodes involve the musculoskeletal system, and in 80% of the cases the joints are involved [1]. Bleeding mainly takes the form of hemarthroses, which often occur spontaneously, without specified etiology, and have repetitive character.…”

Section: Abstract: Hemophilia Arthropathy Hemarthrosis Tranexamic mentioning

confidence: 99%

Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement

Bădulescu¹,

Ciocoiu²,

Filip³

et al. 2019

Rev. Chim.

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Hemophilia is a congenital coagulopathy characterized by a deficiency of coagulation factor VIII or IX. The main complication of this hemopathy is represented by the hemorrhagiparous phenomena that affect mainly the musculoskeletal system. Of the various chronic complications of this condition, hemarthrosis is responsible for the onset of chronic arthropathy, which is a disabling condition. In addition to hematologist-prescribed coagulation factor replacement therapy, acute hemarthrosis and chronic arthropathy management requires close collaboration with both orthopedic surgeons and physiotherapists. This multidisciplinary collaboration is essential both to prevent the onset of hemarthroses and to manage acute bleeding episodes, to assess joint function and to effectively treat hemophilic chronic arthropathy. Hemophilic arthropathy causes significant joint instability and reduced mobility or even total ankylosis, which may lead to permanent disability and hence to a decrease in the patient�s quality of life. From an orthopedic point of view, disabling hemophilic arthropathy may be treated by surgery. Achieving effective hemostasis is vital in order to be able to perform these extremely difficult surgical procedures, due to the high risk of bleeding. This paper aims at highlighting the hemostatic efficacy of tranexamic acid in orthopedic surgery in hemophilic patients who must undergo total joint replacement.

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Bipolar Polyethylene Radial Head Artroplasty in Posttraumatic Unstable Elbows Prosthetic design and clinical results

Cited by 10 publications

References 16 publications

Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?

Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?

Preliminary Investigation on Mechanical Properties of Polymer Coating Screws for the Future Fragility Fracture Fixation

Tranexamic Acid - Major Antifibrinolytic Agent Used to Achieve Hemostasis in Hemophilic Patients with Anti-Factor VIII Anti-Bodies Who Must Undergo Total Joint Replecement

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