Bipolarity and suicidal ideation in children and adolescents: a systematic review with meta-analysis

Abstract

BackgroundAffective disorders in children and adolescents have received growing attention in the world scenario of mental health. Additionally, there has been an increasing prevalence of suicidal ideation in this population.ObjectiveA systematic review with meta-analysis was conducted to demonstrate the main risk factors regarding the development of suicidal ideation in the bipolar disorder.MethodsThis is a systematic review with meta-analysis using the PRISMA protocol (http://www.prisma-statement.org/). This study included secondary data. Original data in mental health were collected by mapping the evidence found in the following electronic databases: MEDLINE/PubMed, LILACS, SciELO, and ScienceDirect in the period from 2005 to 2015.ResultsWe found 1418 registrations in such databases, and 46 of them were selected to comprise this review. The result introduces a joint risk between the studies of 2.94 CI [2.29–3.78]. A significant correlation was verified between the risk factors and the suicidal ideation. The result was r (Pearson) = 0.7103 and p value <0.001.ConclusionChildren and adolescents living with bipolar disorder are more vulnerable to suicidal ideation. These results reinforce the need of a more effective public policy directed toward this population.

Difference in the prevalence of non-fatal suicidal behaviours in patients with unipolar and bipolar depression in China: a meta-analysis

“…Unipolar and bipolar depression are different disease entities. Unlike unipolar depressive disorder, the clinical manifestations and treatment of bipolar depression is more complex, for example, patients with bipolar depression have a worse prognosis [ 8 , 29 ]. Fang et al [ 8 ] argued that patients with bipolar depression have a high rate of non-fatal suicidal behaviour (suicidal ideation and attempt) and a low rate of completed suicide whereas patients with unipolar depression have a low rate of non-fatal suicidal behaviour and a high rate of completed suicide; thus, non-fatal suicidal behaviour can be used as a differential factor for the differentiation between unipolar and bipolar depression.…”

Determinants of Suicidality in the European General Population: A Systematic Review and Meta-Analysis

“…These studies include systematic reviews and/or meta-analyses that have focused on investigating suicidality in the general population [5]; in certain specific populations such as, for example, children and adolescents [6], students [7], prisoners [8] and inpatients [9]; or combinations of different types of populations [10][11][12][13][14]. Factors that have been studied in systematic reviews and/or meta-analyses include individual psychological variables such as hopelessness [10], alexithymia [11] or self-esteem [12], and groups of psychological variables-for example, a systematic review that includes mental pain, communication difficulties, decision-making impulsivity and aggression [14]; mental disorders such as depression [10], affective disorders [15], anxiety disorders [16], obsessive compulsive disorder [17], substance use [18], psychosis [19], comorbid obsessive compulsive disorder and bipolar disorder [20], and any mental disorder [8,13]; medical problems and conditions such as inflammatory cytokines [21], concussion [22], psoriasis [23] and body mass index [24]; demographic factors such as gender [25], sexual minority [26], poverty [27], marital status [28], employment situation [29] and age [12,13,[30][31][32], or various demographic factors together [14]; psychosocial factors such as adverse life e...…”

Increased Asymmetric Perfusion of the Cerebral Cortices and Thalamus Indicates Individuals at Risk for Bipolar Disorder: A Family Cohort Single Photon Emission Computed Tomography Neuroimaging Study

“…Lastly, the presence of bipolar disorder, in and of itself, has been shown to increase the risk of suicide, up to 14-fold ( 28 ), underscoring the importance of early and correct diagnosis. Children with bipolar disorder are at higher risk for suicide than children with unipolar depression ( 82 , 83 ). Suicide attempts are considerably more likely to be lethal among those with bipolar disorder ( 84 ) and occur at a younger age ( 83 , 84 ).…”

“…Children with bipolar disorder are at higher risk for suicide than children with unipolar depression ( 82 , 83 ). Suicide attempts are considerably more likely to be lethal among those with bipolar disorder ( 84 ) and occur at a younger age ( 83 , 84 ). Recently, Orsolini et al ( 85 ) thoroughly reviewed suicide and depressive disorders, noting the interwoven roles of neurobiological, neuroimmunological, and psychosocial factors.…”